SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1dfoA-3sgeH:
undetectable		 1dfoA-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1dfoB-3sgeH:
undetectable		 1dfoB-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1dfoC-3sgeH:
undetectable		 1dfoC-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1dfoD-3sgeH:
undetectable		 1dfoD-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 3sge HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 119
PRO H 149
THR H 118
PRO H 120
 None
 1.29A 1dsdC-3sgeH:
undetectable		 1dsdC-3sgeH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 3sge HEAVY CHAIN
(Mus
musculus) 		4 / 4 THR H 119
PRO H 149
THR H 118
PRO H 120
 None
 1.29A 1dsdC-3sgeH:
undetectable		 1dsdC-3sgeH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.10A 1eqbA-3sgeH:
undetectable		 1eqbA-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.09A 1eqbB-3sgeH:
undetectable		 1eqbB-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.10A 1eqbC-3sgeH:
undetectable		 1eqbC-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 LEU H 140
VAL H 195
ALA H 132
ASN H 135
SER H 188
 None
 1.10A 1eqbD-3sgeH:
undetectable		 1eqbD-3sgeH:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.43A 2y03A-3sgeH:
undetectable		 2y03A-3sgeH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.47A 2y03B-3sgeH:
undetectable		 2y03B-3sgeH:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.39A 3nyaA-3sgeH:
undetectable		 3nyaA-3sgeH:
17.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 VAL H   2
ALA H  24
MET H  34
ARG H  74
TYR H 104
 None
 0.88A 3qxvB-3sgeH:
20.1		 3qxvB-3sgeH:
37.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3sge HEAVY CHAIN
(Mus
musculus) 		5 / 12 ALA H  24
SER H  28
MET H  34
ARG H  74
TYR H 104
 None
 1.02A 3qxvE-3sgeH:
16.5		 3qxvE-3sgeH:
37.20