SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sgh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 183
ALA A 125
LEU A  43
VAL A 195
ILE A 123
 None
 1.20A 1claA-3sghA:
undetectable		 1claA-3sghA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 209
LEU A 129
MET A 169
 None
 0.76A 1mx1D-3sghA:
undetectable		 1mx1D-3sghA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 452
ASP A 443
LEU A 137
LEU A 141
 None
 1.02A 2bfpA-3sghA:
undetectable		 2bfpA-3sghA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A  95
TRP A  65
ASP A  96
THR A 482
LEU A 138
 None
 1.24A 3iv6A-3sghA:
undetectable		 3iv6A-3sghA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 310
GLY A  70
SER A  67
ASN A 274
ILE A 459
 None
 1.29A 3k13C-3sghA:
undetectable		 3k13C-3sghA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 280
TYR A 284
TYR A 385
PHE A 374
 None
 1.13A 3ku9B-3sghA:
undetectable		 3ku9B-3sghA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 447
ALA A 449
ILE A 459
PHE A  68
ASP A 443
 None
 1.01A 3nmuB-3sghA:
0.6
3nmuJ-3sghA:
undetectable		 3nmuB-3sghA:
21.08
3nmuJ-3sghA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 367
GLY A 369
PHE A 374
ALA A 439
GLN A 435
 None
 1.07A 3nvkF-3sghA:
undetectable
3nvkJ-3sghA:
undetectable		 3nvkF-3sghA:
20.31
3nvkJ-3sghA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 336
GLY A 255
PHE A  47
SER A  44
GLU A 259
 None
 1.05A 3t7sB-3sghA:
undetectable		 3t7sB-3sghA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 336
GLY A 255
PHE A  47
SER A  44
GLU A 259
 None
 1.08A 3t7sD-3sghA:
undetectable		 3t7sD-3sghA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 441
PRO A 287
ARG A 288
ILE A 417
TYR A 284
 None
 1.35A 4a99A-3sghA:
undetectable
4a99C-3sghA:
undetectable		 4a99A-3sghA:
21.34
4a99C-3sghA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 220
ARG A 453
TRP A 513
 None
 1.48A 4b7nA-3sghA:
undetectable		 4b7nA-3sghA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.06A 4c5lA-3sghA:
undetectable		 4c5lA-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 9 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.09A 4c5lB-3sghA:
undetectable		 4c5lB-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.02A 4c5lC-3sghA:
undetectable		 4c5lC-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.09A 4c5lD-3sghA:
undetectable		 4c5lD-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 196
GLY A 201
VAL A 195
VAL A 122
CYH A 203
 None
 1.08A 4c5nB-3sghA:
undetectable		 4c5nB-3sghA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 220
ARG A 453
TRP A 513
 None
 1.45A 4cpzC-3sghA:
undetectable		 4cpzC-3sghA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ASN A  62
GLU A  60
ILE A  61
ASN A  48
 None
 0.91A 4d39B-3sghA:
undetectable		 4d39B-3sghA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 102
LEU A 141
MET A 445
TRP A 166
 None
 1.28A 4do3A-3sghA:
undetectable		 4do3A-3sghA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 MET A 515
MET A 445
TYR A 456
 None
 1.29A 4p6xI-3sghA:
undetectable		 4p6xI-3sghA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 174
LEU A 173
PHE A 170
 None
 0.45A 4pthA-3sghA:
undetectable		 4pthA-3sghA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 222
GLY A 223
ARG A 453
GLU A 350
 None
 0.97A 4r82A-3sghA:
undetectable
4r82B-3sghA:
undetectable		 4r82A-3sghA:
18.07
4r82B-3sghA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 194
ALA A 193
ASN A 189
GLN A 190
 None
None
CL  A 614 ( 4.1A)
None
 1.41A 4zgfA-3sghA:
undetectable		 4zgfA-3sghA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 218
ASP A 171
PHE A 170
THR A 178
GLU A 235
 None
 1.22A 5hfjD-3sghA:
undetectable		 5hfjD-3sghA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 279
VAL A 278
GLY A 306
ALA A 275
 None
 1.02A 5k50A-3sghA:
undetectable		 5k50A-3sghA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 289
ARG A 288
ALA A 291
PRO A 290
 None
 0.87A 5odqA-3sghA:
undetectable		 5odqA-3sghA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 133
VAL A 338
ASP A 251
ALA A  51
 None
 1.11A 5otrA-3sghA:
undetectable		 5otrA-3sghA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 396
ASP A 398
LEU A 400
TYR A 320
 None
 0.97A 5ov9A-3sghA:
undetectable		 5ov9A-3sghA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 396
ASP A 398
LEU A 400
TYR A 320
 None
 1.00A 5ov9B-3sghA:
undetectable		 5ov9B-3sghA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6U_D_FYPD410_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2)		 3sgh SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 9 SER A 248
TYR A 199
TYR A 340
ALA A 344
THR A 212
 None
 1.47A 6d6uD-3sghA:
1.4
6d6uE-3sghA:
0.6		 6d6uD-3sghA:
20.00
6d6uE-3sghA:
21.71