SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sgz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		3 / 3 GLU A  36
THR A  33
LEU A 226
 None
 0.69A 1v8bC-3sgzA:
undetectable		 1v8bC-3sgzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 ALA A 257
SER A 258
ASN A  37
ILE A  38
 None
 1.02A 1yc2A-3sgzA:
undetectable		 1yc2A-3sgzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 5 ALA A 257
ILE A 259
ASN A  37
ILE A  38
 None
 1.09A 2h4jA-3sgzA:
undetectable		 2h4jA-3sgzA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 5 LEU A 147
ARG A 124
ALA A 144
ILE A 115
 None
 1.12A 2qhfA-3sgzA:
undetectable		 2qhfA-3sgzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		3 / 3 PHE A 199
SER A 105
LEU A 128
 HO6  A 402 ( 4.8A)
FMN  A 401 (-2.8A)
None
 0.77A 2w1bA-3sgzA:
undetectable		 2w1bA-3sgzA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ALA A 261
ILE A 259
ARG A 263
GLU A 232
ALA A 268
 None
 1.24A 3axtA-3sgzA:
undetectable		 3axtA-3sgzA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 5 LEU A 218
GLN A 142
THR A 216
LEU A 112
 None
 1.06A 3ce6D-3sgzA:
undetectable		 3ce6D-3sgzA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 7 LEU A 233
VAL A 141
ILE A 154
ARG A 217
 None
 1.08A 3ik3A-3sgzA:
undetectable		 3ik3A-3sgzA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ILE A  38
GLY A 280
GLY A 279
PRO A 303
ILE A 259
 None
FMN  A 401 (-3.8A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.8A)
None
 1.11A 3jayA-3sgzA:
undetectable		 3jayA-3sgzA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_A_PXLA400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.30A 3mbhA-3sgzA:
undetectable		 3mbhA-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_B_PXLB400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.30A 3mbhB-3sgzA:
undetectable		 3mbhB-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_C_PXLC400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.30A 3mbhC-3sgzA:
undetectable		 3mbhC-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_D_PXLD400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.31A 3mbhD-3sgzA:
undetectable		 3mbhD-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_E_PXLE400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.30A 3mbhE-3sgzA:
undetectable		 3mbhE-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBH_F_PXLF400_1
(PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ASP A 278
SER A 245
VAL A 243
THR A 155
VAL A 103
 FMN  A 401 (-2.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.8A)
None
 1.28A 3mbhF-3sgzA:
undetectable		 3mbhF-3sgzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 7 THR A  33
GLY A 248
ASN A 246
GLY A 162
 None
FMN  A 401 (-3.3A)
None
None
 0.72A 3tajA-3sgzA:
undetectable		 3tajA-3sgzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 ALA A 325
ALA A  70
PRO A  71
THR A  59
 None
 0.83A 4dtzA-3sgzA:
undetectable		 4dtzA-3sgzA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 ALA A 325
ALA A  70
PRO A  71
THR A  59
 None
 0.86A 4dtzB-3sgzA:
undetectable		 4dtzB-3sgzA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.15A 4e47A-3sgzA:
undetectable		 4e47A-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.15A 4e47B-3sgzA:
undetectable		 4e47B-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_C_SAMC800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.13A 4e47C-3sgzA:
undetectable		 4e47C-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 GLY A 280
GLY A 279
ASN A 246
ILE A 298
 FMN  A 401 (-3.8A)
FMN  A 401 (-3.4A)
None
None
 0.97A 4fglD-3sgzA:
undetectable		 4fglD-3sgzA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 THR A  33
GLY A 248
ASN A 246
GLY A 162
 None
FMN  A 401 (-3.3A)
None
None
 0.77A 4fjpA-3sgzA:
undetectable		 4fjpA-3sgzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 7 THR A  33
GLY A 248
ASN A 246
GLY A 162
 None
FMN  A 401 (-3.3A)
None
None
 0.72A 4forA-3sgzA:
undetectable		 4forA-3sgzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.15A 4jdsA-3sgzA:
undetectable		 4jdsA-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.15A 4jdsB-3sgzA:
undetectable		 4jdsB-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_C_SAMC401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.16A 4jdsC-3sgzA:
undetectable		 4jdsC-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLG_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.23A 4jlgA-3sgzA:
undetectable		 4jlgA-3sgzA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 GLY A 279
GLY A 248
ILE A 259
ALA A 257
ASP A 286
 FMN  A 401 (-3.4A)
FMN  A 401 (-3.3A)
None
None
None
 1.11A 4kicA-3sgzA:
undetectable		 4kicA-3sgzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 GLY A 279
GLY A 248
ILE A 259
ALA A 257
ASP A 286
 FMN  A 401 (-3.4A)
FMN  A 401 (-3.3A)
None
None
None
 1.10A 4kicB-3sgzA:
undetectable		 4kicB-3sgzA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 10 LEU A 327
LEU A 320
LEU A 300
ILE A 298
LEU A 291
 None
 1.08A 4odoC-3sgzA:
undetectable		 4odoC-3sgzA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 9 TYR A 276
ALA A 151
ARG A 217
ILE A 220
ILE A 221
 None
 1.31A 4oknB-3sgzA:
undetectable		 4oknB-3sgzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 PHE A 299
GLY A 301
ILE A 298
TYR A 276
TYR A 102
 None
FMN  A 401 (-3.4A)
None
None
None
 1.15A 4rtsA-3sgzA:
undetectable		 4rtsA-3sgzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 11 ILE A  24
GLY A  26
GLU A  27
GLY A 279
ASN A  37
 FMN  A 401 (-4.7A)
None
None
FMN  A 401 (-3.4A)
None
 1.11A 5ayfA-3sgzA:
undetectable		 5ayfA-3sgzA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 7 ARG A 282
ASP A 278
GLY A 249
THR A 158
 FMN  A 401 (-2.9A)
FMN  A 401 (-2.8A)
None
HO6  A 402 ( 4.6A)
 1.04A 5btfA-3sgzA:
undetectable
5btfC-3sgzA:
undetectable
5btfD-3sgzA:
undetectable		 5btfA-3sgzA:
22.31
5btfC-3sgzA:
22.31
5btfD-3sgzA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		3 / 3 ILE A  44
MET A 331
ASP A 286
 None
 0.79A 5h2uA-3sgzA:
undetectable		 5h2uA-3sgzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ASP A   7
ALA A   6
LYS A 289
GLY A 284
GLU A 326
 None
 1.27A 5hfjE-3sgzA:
undetectable		 5hfjE-3sgzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 GLU A  88
LEU A 161
ASP A 167
SER A 109
THR A 158
 None
HO6  A 402 ( 4.5A)
None
None
HO6  A 402 ( 4.6A)
 1.35A 5hnzB-3sgzA:
undetectable		 5hnzB-3sgzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 10 ILE A  72
ILE A 298
THR A  61
GLU A 274
ILE A  63
 None
 1.27A 5lg3G-3sgzA:
undetectable		 5lg3G-3sgzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 10 ILE A  72
ILE A 298
THR A  61
GLU A 274
ILE A  63
 None
 1.27A 5lg3H-3sgzA:
undetectable		 5lg3H-3sgzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 ILE A 104
ILE A 298
VAL A 319
LEU A 320
ILE A 100
 None
 0.96A 5mueA-3sgzA:
undetectable		 5mueA-3sgzA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 12 SER A  90
LYS A  89
GLU A 318
GLU A 313
LEU A 308
 None
 1.15A 5nwvA-3sgzA:
undetectable		 5nwvA-3sgzA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 THR A  61
ARG A 296
ILE A 342
GLU A 341
 None
 0.85A 5uigA-3sgzA:
undetectable		 5uigA-3sgzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 5 VAL A 281
ARG A 282
PRO A 303
GLY A 301
 None
FMN  A 401 (-2.9A)
FMN  A 401 (-4.8A)
FMN  A 401 (-3.4A)
 1.05A 5x80A-3sgzA:
0.1
5x80B-3sgzA:
0.2		 5x80A-3sgzA:
18.77
5x80B-3sgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		5 / 7 VAL A 281
ARG A 282
VAL A 319
PRO A 303
GLY A 301
 None
FMN  A 401 (-2.9A)
None
FMN  A 401 (-4.8A)
FMN  A 401 (-3.4A)
 1.31A 5x80C-3sgzA:
undetectable
5x80D-3sgzA:
undetectable		 5x80C-3sgzA:
18.77
5x80D-3sgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 5 PRO A 303
GLY A 301
VAL A 281
ARG A 282
 FMN  A 401 (-4.8A)
FMN  A 401 (-3.4A)
None
FMN  A 401 (-2.9A)
 1.09A 5x80C-3sgzA:
undetectable
5x80D-3sgzA:
undetectable		 5x80C-3sgzA:
18.77
5x80D-3sgzA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3sgz HYDROXYACID OXIDASE
2
(Rattus
norvegicus) 		4 / 6 SER A  81
GLY A  87
THR A  91
ILE A  74
 None
 0.84A 6f8cA-3sgzA:
undetectable		 6f8cA-3sgzA:
18.11