SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3shi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.27A 1os2A-3shiA:
29.5		 1os2A-3shiA:
57.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.26A 1os2D-3shiA:
29.5		 1os2D-3shiA:
57.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.24A 1uttA-3shiA:
29.6		 1uttA-3shiA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.28A 1utzA-3shiA:
29.6		 1utzA-3shiA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.29A 1utzB-3shiA:
29.7		 1utzB-3shiA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.30A 1y93A-3shiA:
30.0		 1y93A-3shiA:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.23A 2hu6A-3shiA:
30.0		 2hu6A-3shiA:
57.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.32A 2jihA-3shiA:
10.2		 2jihA-3shiA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 8 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.33A 2jihB-3shiA:
9.3		 2jihB-3shiA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.47A 2ow9A-3shiA:
28.8		 2ow9A-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.31A 2ow9B-3shiA:
28.8		 2ow9B-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.33A 2ozrC-3shiA:
29.0		 2ozrC-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.32A 2ozrD-3shiA:
29.2		 2ozrD-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.31A 2ozrE-3shiA:
28.6		 2ozrE-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 HIS A 218
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.22A 2ozrF-3shiA:
28.1		 2ozrF-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		3 / 3 HIS A 183
GLU A 219
HIS A 222
 ZN  A 302 (-3.1A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
 0.53A 3ba0A-3shiA:
26.7		 3ba0A-3shiA:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_A_097A801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.35A 3hy7A-3shiA:
10.7		 3hy7A-3shiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 9 LEU A 181
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 None
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.32A 3hy7B-3shiA:
10.6		 3hy7B-3shiA:
23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.27A 3kecA-3shiA:
28.6		 3kecA-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.40A 3likA-3shiA:
29.9		 3likA-3shiA:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.27A 3lilA-3shiA:
30.1		 3lilA-3shiA:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.26A 3ljgA-3shiA:
30.1		 3ljgA-3shiA:
57.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.38A 3lkaA-3shiA:
30.0		 3lkaA-3shiA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		5 / 6 HIS A 183
HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.48A 4a7bA-3shiA:
28.9		 4a7bA-3shiA:
58.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 183
HIS A 218
GLU A 219
HIS A 222
 ZN  A 302 (-3.1A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
 0.25A 4a7bB-3shiA:
28.5		 4a7bB-3shiA:
58.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 GLN A 257
THR A 145
LEU A 235
LEU A 248
 None
 1.24A 5m5kB-3shiA:
undetectable		 5m5kB-3shiA:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 4 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.25A 5n5jA-3shiA:
30.1		 5n5jA-3shiA:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3shi INTERSTITIAL
COLLAGENASE
(Homo
sapiens) 		4 / 5 HIS A 218
GLU A 219
HIS A 222
HIS A 228
 ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.3A)
 0.28A 5n5kA-3shiA:
29.6		 5n5kA-3shiA:
57.41