SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.08A 1draB-3shoA:
undetectable		 1draB-3shoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 4 THR A 235
LEU A 247
VAL A 250
LEU A 254
 None
 0.71A 1fbmD-3shoA:
undetectable		 1fbmD-3shoA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 4 THR A 235
LEU A 247
VAL A 250
LEU A 254
 None
 0.81A 1mz9D-3shoA:
undetectable		 1mz9D-3shoA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.05A 1ra3A-3shoA:
undetectable		 1ra3A-3shoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 247
LEU A 231
ALA A 126
ALA A 127
LEU A 152
 None
 1.38A 1rbpA-3shoA:
undetectable		 1rbpA-3shoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 10 LEU A 185
ALA A 123
ALA A 127
VAL A 137
LEU A 152
 None
 1.23A 1rlbE-3shoA:
undetectable		 1rlbE-3shoA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 215
ALA A 233
LEU A 231
THR A 115
 None
 1.05A 2roxB-3shoA:
undetectable		 2roxB-3shoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 11 LEU A 185
ALA A 126
ALA A 127
VAL A 137
LEU A 152
 None
 1.28A 3bszE-3shoA:
undetectable		 3bszE-3shoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 215
ALA A 233
LEU A 231
THR A 115
 None
 0.99A 3cfqA-3shoA:
undetectable		 3cfqA-3shoA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.08A 3drcB-3shoA:
undetectable		 3drcB-3shoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.04A 3erdA-3shoA:
undetectable		 3erdA-3shoA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 9 LEU A 215
THR A 235
ALA A 233
LEU A 231
THR A 115
 None
 1.37A 3ozkA-3shoA:
undetectable		 3ozkA-3shoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 9 ILE A 161
GLY A 160
VAL A 139
THR A 163
GLY A 153
 None
 1.11A 4acaB-3shoA:
5.8
4acaC-3shoA:
5.7		 4acaB-3shoA:
17.08
4acaC-3shoA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 7 LEU A 215
THR A 235
ALA A 233
LEU A 231
THR A 115
 None
 1.49A 4d7bA-3shoA:
undetectable		 4d7bA-3shoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.09A 4dfrB-3shoA:
undetectable		 4dfrB-3shoA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 215
ALA A 233
LEU A 231
THR A 115
 None
 1.03A 4i89A-3shoA:
undetectable		 4i89A-3shoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 9 VAL A 148
ALA A 149
PHE A 144
SER A 190
GLY A 141
 None
 1.26A 4mmbA-3shoA:
undetectable		 4mmbA-3shoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 9 VAL A 148
ALA A 149
PHE A 144
SER A 190
GLY A 141
 None
 1.26A 4mmfA-3shoA:
undetectable		 4mmfA-3shoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 9 VAL A 148
ALA A 149
PHE A 144
SER A 190
GLY A 141
 None
 1.28A 4mmfB-3shoA:
undetectable		 4mmfB-3shoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.07A 4nx6A-3shoA:
2.4		 4nx6A-3shoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.10A 4nx7A-3shoA:
2.4		 4nx7A-3shoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 ALA A 126
LEU A 231
ILE A 187
LEU A 152
ILE A 131
 None
None
None
None
OCS  A 132 ( 3.7A)
 1.05A 4pstA-3shoA:
undetectable		 4pstA-3shoA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 12 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.12A 4zn7A-3shoA:
undetectable		 4zn7A-3shoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		5 / 11 LEU A 166
ALA A 201
LEU A 180
LEU A 177
HIS A 136
 None
 1.11A 4zn7B-3shoA:
undetectable		 4zn7B-3shoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 215
ALA A 233
LEU A 231
THR A 115
 None
 1.05A 5bojA-3shoA:
undetectable		 5bojA-3shoA:
21.79