SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3shr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		3 / 3 VAL A 141
VAL A 139
TRP A 189
 None
 0.67A 1bdwA-3shrA:
undetectable
1bdwB-3shrA:
undetectable		 1bdwA-3shrA:
6.29
1bdwB-3shrA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.33A 1cd2A-3shrA:
undetectable		 1cd2A-3shrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.66A 1cd2A-3shrA:
undetectable		 1cd2A-3shrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 11 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.71A 1dyrA-3shrA:
undetectable		 1dyrA-3shrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.38A 1ra2A-3shrA:
undetectable		 1ra2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.72A 1ra2A-3shrA:
undetectable		 1ra2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.37A 1ra8A-3shrA:
undetectable		 1ra8A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.72A 1ra8A-3shrA:
undetectable		 1ra8A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.39A 1rb2A-3shrA:
undetectable		 1rb2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.76A 1rb2A-3shrA:
undetectable		 1rb2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.13A 1rb2B-3shrA:
undetectable		 1rb2B-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.20A 1rb3A-3shrA:
undetectable		 1rb3A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.05A 1re7A-3shrA:
undetectable		 1re7A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.72A 1re7A-3shrA:
undetectable		 1re7A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.37A 1rx2A-3shrA:
undetectable		 1rx2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.71A 1rx2A-3shrA:
undetectable		 1rx2A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.76A 2d0kA-3shrA:
undetectable		 2d0kA-3shrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.33A 2d0kB-3shrA:
undetectable		 2d0kB-3shrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.73A 2d0kB-3shrA:
undetectable		 2d0kB-3shrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 6 GLU A 167
MET A 200
LYS A 104
ILE A 114
 CMP  A 401 (-2.8A)
None
None
None
 1.24A 2w98B-3shrA:
undetectable		 2w98B-3shrA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 4 ILE A 130
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
None
None
CMP  A 401 (-2.8A)
 1.14A 3ia4A-3shrA:
undetectable		 3ia4A-3shrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 4 ILE A 248
PHE A 289
ILE A 247
THR A 301
 None
 0.73A 3ia4A-3shrA:
undetectable		 3ia4A-3shrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		3 / 3 GLU A  95
LEU A  98
ASP A  99
 None
 0.44A 3ko0A-3shrA:
undetectable		 3ko0A-3shrA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		3 / 3 GLU A  95
LEU A  98
ASP A  99
 None
 0.31A 3ko0T-3shrA:
undetectable		 3ko0T-3shrA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.25A 3qgtB-3shrA:
undetectable		 3qgtB-3shrA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.20A 3ql3A-3shrA:
undetectable		 3ql3A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 9 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.22A 3tq8A-3shrA:
undetectable		 3tq8A-3shrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 9 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.80A 3tq8A-3shrA:
undetectable		 3tq8A-3shrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 5 THR A 203
ILE A 206
LYS A 207
GLU A 210
 None
 0.67A 4ac9C-3shrA:
undetectable		 4ac9C-3shrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 5 THR A 203
ILE A 206
LYS A 207
GLU A 210
 None
 0.68A 4acaC-3shrA:
undetectable		 4acaC-3shrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 5 THR A 203
ILE A 206
LYS A 207
GLU A 210
 None
 0.70A 4acbC-3shrA:
undetectable		 4acbC-3shrA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.75A 4g8zX-3shrA:
undetectable		 4g8zX-3shrA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.44A 4kjlA-3shrA:
undetectable		 4kjlA-3shrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.70A 4kjlA-3shrA:
undetectable		 4kjlA-3shrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 130
ALA A 178
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.16A 4km0A-3shrA:
undetectable		 4km0A-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 10 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.72A 4km0A-3shrA:
undetectable		 4km0A-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.73A 4km0B-3shrA:
undetectable		 4km0B-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.00A 4km2A-3shrA:
undetectable		 4km2A-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_B_TOPB202_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.09A 4km2B-3shrA:
undetectable		 4km2B-3shrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 11 ILE A 130
ALA A 178
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.17A 4p66A-3shrA:
undetectable		 4p66A-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 130
ALA A 178
PHE A 165
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
CMP  A 401 (-2.8A)
 1.08A 4ptjA-3shrA:
undetectable		 4ptjA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.68A 4ptjA-3shrA:
undetectable		 4ptjA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.32A 4x5iA-3shrA:
undetectable		 4x5iA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.77A 4x5iA-3shrA:
undetectable		 4x5iA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.80A 4x5jA-3shrA:
undetectable		 4x5jA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.11A 5e8qA-3shrA:
undetectable		 5e8qA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.76A 5e8qA-3shrA:
undetectable		 5e8qA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.78A 5eajA-3shrA:
undetectable		 5eajA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		4 / 7 ALA A 233
LYS A 207
GLU A 210
HIS A 208
 None
 0.99A 5ecnA-3shrA:
undetectable		 5ecnA-3shrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 TYR A 211
ILE A 247
PHE A 289
VAL A 265
SER A 261
 None
 1.49A 5l8oB-3shrA:
undetectable		 5l8oB-3shrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.41A 5ujxA-3shrA:
undetectable		 5ujxA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.77A 5ujxA-3shrA:
undetectable		 5ujxA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.39A 5z6jA-3shrA:
undetectable		 5z6jA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.69A 5z6jA-3shrA:
undetectable		 5z6jA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.38A 5z6kA-3shrA:
undetectable		 5z6kA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.71A 5z6kA-3shrA:
undetectable		 5z6kA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 11 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.25A 5z6mA-3shrA:
undetectable		 5z6mA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 11 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.73A 5z6mA-3shrA:
undetectable		 5z6mA-3shrA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		6 / 12 ILE A 130
ALA A 178
PHE A 165
LEU A 188
ILE A 129
THR A 177
 CMP  A 401 (-4.1A)
CMP  A 401 (-3.8A)
None
None
None
CMP  A 401 (-2.8A)
 1.36A 7dfrA-3shrA:
undetectable		 7dfrA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
ILE A 260
ILE A 247
THR A 301
 None
 1.08A 7dfrA-3shrA:
undetectable		 7dfrA-3shrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3shr CGMP-DEPENDENT
PROTEIN KINASE 1
(Bos
taurus) 		5 / 12 ILE A 248
ALA A 302
PHE A 289
ILE A 247
THR A 301
 None
 0.68A 7dfrA-3shrA:
undetectable		 7dfrA-3shrA:
19.26