SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3si1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		3 / 3 LEU A 138
LEU A 196
SER A 126
 None
 0.65A 1tlmA-3si1A:
undetectable		 1tlmA-3si1A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		5 / 10 LEU A 272
ALA A 274
ILE A 275
ALA A  47
LEU A 360
 None
 0.86A 1xp0A-3si1A:
undetectable		 1xp0A-3si1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 5 ILE A 345
LEU A 348
ASP A 287
ALA A 342
 None
 1.05A 2opxA-3si1A:
undetectable		 2opxA-3si1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 6 LEU A  74
LEU A  71
ILE A  92
ARG A  95
 None
 1.07A 2rlfA-3si1A:
undetectable
2rlfB-3si1A:
undetectable		 2rlfA-3si1A:
12.35
2rlfB-3si1A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 6 LEU A  74
LEU A  71
ILE A  92
ARG A  95
 None
 0.76A 2rlfB-3si1A:
undetectable
2rlfC-3si1A:
undetectable		 2rlfB-3si1A:
12.35
2rlfC-3si1A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 7 TYR A  86
SER A  85
ILE A  92
SER A 122
 None
 1.03A 2xz5A-3si1A:
undetectable
2xz5B-3si1A:
undetectable		 2xz5A-3si1A:
19.51
2xz5B-3si1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 8 TYR A  86
SER A  85
ILE A  92
SER A 122
 None
 0.97A 2xz5B-3si1A:
undetectable
2xz5E-3si1A:
undetectable		 2xz5B-3si1A:
19.51
2xz5E-3si1A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		3 / 3 ASP A 307
GLU A 203
GLY A 201
 None
ZN  A 601 (-2.3A)
None
 0.63A 3w9tA-3si1A:
undetectable		 3w9tA-3si1A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 6 PHE A 199
ILE A 197
ARG A 195
VAL A 318
 None
 1.21A 4mk4B-3si1A:
2.0		 4mk4B-3si1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		5 / 11 HIS A 141
ASP A 160
GLU A 202
GLU A 203
HIS A 331
 None
ZN  A 601 (-2.0A)
None
ZN  A 601 (-2.3A)
ZN  A 601 (-3.6A)
 0.68A 4pqaA-3si1A:
20.5		 4pqaA-3si1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 8 SER A  87
ALA A  88
PRO A  73
LEU A  75
 None
 1.21A 5dzkF-3si1A:
undetectable
5dzkT-3si1A:
undetectable		 5dzkF-3si1A:
22.42
5dzkT-3si1A:
0.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 7 GLY A 252
ALA A 162
ASP A 249
ASN A 339
 None
 0.96A 5mvsA-3si1A:
undetectable		 5mvsA-3si1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 8 GLY A 252
ALA A 162
ASP A 249
ASN A 339
 None
 0.95A 5mvsB-3si1A:
undetectable		 5mvsB-3si1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Mus
musculus) 		4 / 5 LEU A 192
ILE A 124
MET A 242
GLY A 241
 None
 1.00A 6hd6A-3si1A:
undetectable		 6hd6A-3si1A:
16.50