SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 12 LEU A  94
THR A  76
LEU A 123
LEU A 117
GLY A 116
 None
AR6  A 280 (-4.3A)
None
None
None
 1.14A 1d4fD-3sigA:
undetectable		 1d4fD-3sigA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 9 LEU A  94
ALA A 209
LEU A 242
LEU A 206
PHE A 238
 None
 1.11A 1nr6A-3sigA:
undetectable		 1nr6A-3sigA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 6 THR A  75
ASP A 161
SER A 120
VAL A 157
 AR6  A 280 (-4.4A)
None
None
None
 1.20A 2hdnI-3sigA:
undetectable
2hdnJ-3sigA:
undetectable
2hdnL-3sigA:
undetectable		 2hdnI-3sigA:
9.52
2hdnJ-3sigA:
22.93
2hdnL-3sigA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 6 SER A 120
VAL A 157
THR A  75
ASP A 161
 None
None
AR6  A 280 (-4.4A)
None
 1.16A 2hdnJ-3sigA:
undetectable
2hdnK-3sigA:
undetectable
2hdnL-3sigA:
undetectable		 2hdnJ-3sigA:
22.93
2hdnK-3sigA:
9.52
2hdnL-3sigA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		3 / 3 PHE A 238
SER A 177
LEU A 175
 None
 0.76A 2w1bA-3sigA:
undetectable		 2w1bA-3sigA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		6 / 12 GLY A 104
ALA A 118
LEU A 123
ASN A  95
PRO A 178
PHE A 133
 AR6  A 280 (-3.3A)
None
None
None
None
None
 1.46A 3dmhA-3sigA:
undetectable		 3dmhA-3sigA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 8 SER A 120
VAL A 157
THR A  76
VAL A 172
 None
None
AR6  A 280 (-4.3A)
None
 1.15A 3fhxB-3sigA:
undetectable		 3fhxB-3sigA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 8 LEU A  77
ARG A  81
THR A  84
GLY A 122
 None
 0.84A 3ny4A-3sigA:
undetectable		 3ny4A-3sigA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 9 HIS A 148
LEU A  45
THR A 176
LEU A 127
SER A 126
 None
 1.13A 3q1eB-3sigA:
undetectable
3q1eD-3sigA:
undetectable		 3q1eB-3sigA:
17.75
3q1eD-3sigA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
GLN A 113
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 0.90A 4l8fB-3sigA:
undetectable		 4l8fB-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
HIS A 111
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 1.08A 4l8fB-3sigA:
undetectable		 4l8fB-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 11 GLY A 105
GLY A 104
GLY A 103
ALA A 110
HIS A 111
 None
AR6  A 280 (-3.3A)
None
AR6  A 280 ( 4.9A)
None
 1.07A 4l8fD-3sigA:
undetectable		 4l8fD-3sigA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		4 / 5 VAL A 157
VAL A 155
GLY A 154
PHE A 174
 None
 1.10A 5d4nA-3sigA:
undetectable
5d4nC-3sigA:
undetectable		 5d4nA-3sigA:
18.98
5d4nC-3sigA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE
(Thermomonospora
curvata) 		5 / 12 LEU A 149
THR A 237
PHE A 238
LEU A 241
HIS A 214
 None
 1.24A 5dlvA-3sigA:
undetectable		 5dlvA-3sigA:
15.67