SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3sip CASPASE
(Drosophila
melanogaster) 		3 / 3 PHE A 117
TYR A  68
TYR A 109
 None
 1.02A 1x70B-3sipA:
undetectable		 1x70B-3sipA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3sip APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		5 / 12 PHE E  82
GLY E  84
CYH E  80
LEU E  64
LEU E  41
 None
None
ZN  E   1 (-2.3A)
None
None
 1.20A 1zgyA-3sipE:
undetectable		 1zgyA-3sipE:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sip CASPASE
CASPASE
(Drosophila
melanogaster;
Drosophila
melanogaster) 		5 / 12 LEU B 198
PHE B 194
LEU A  49
ILE B 245
VAL A  62
 None
 1.25A 2pnjB-3sipB:
undetectable		 2pnjB-3sipB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sip CASPASE
CASPASE
(Drosophila
melanogaster;
Drosophila
melanogaster) 		5 / 12 LEU B 198
PHE B 194
LEU A  49
ILE B 245
VAL A  62
 None
 1.17A 2po5A-3sipB:
undetectable		 2po5A-3sipB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3sip CASPASE
(Drosophila
melanogaster) 		5 / 11 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.86A 2q72A-3sipA:
undetectable		 2q72A-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3sip CASPASE
(Drosophila
melanogaster) 		5 / 12 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.85A 2qb4A-3sipA:
undetectable		 2qb4A-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3sip CASPASE
(Drosophila
melanogaster) 		5 / 11 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.88A 2qjuA-3sipA:
undetectable		 2qjuA-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 3sip APOPTOSIS 1
INHIBITOR
CASPASE
(Drosophila
melanogaster) 		4 / 8 ASP E  76
ASP E  94
GLY A   3
THR E  72
 None
 0.81A 3el9A-3sipE:
undetectable		 3el9A-3sipE:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3sip CASPASE
(Drosophila
melanogaster) 		5 / 12 LEU A 111
GLN A 108
ILE A 114
ALA A 104
LEU A  72
 None
 0.98A 3gwvA-3sipA:
undetectable		 3gwvA-3sipA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 3sip APOPTOSIS 1
INHIBITOR
(Drosophila
melanogaster) 		4 / 8 PHE E  51
LEU E  56
PRO E  55
TRP E  90
 None
 0.95A 3jq7B-3sipE:
undetectable		 3jq7B-3sipE:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3sip CASPASE
CASPASE
(Drosophila
melanogaster;
Drosophila
melanogaster) 		3 / 3 SER B 192
ASP A  45
ASN A  27
 None
 1.03A 3lsfB-3sipB:
undetectable
3lsfE-3sipB:
undetectable		 3lsfB-3sipB:
16.15
3lsfE-3sipB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3sip CASPASE
CASPASE
(Drosophila
melanogaster;
Drosophila
melanogaster) 		3 / 3 ASP A  45
ASN A  27
SER B 192
 None
 0.96A 3lsfB-3sipA:
undetectable
3lsfE-3sipA:
undetectable		 3lsfB-3sipA:
19.62
3lsfE-3sipA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sip CASPASE
CASPASE
(Drosophila
melanogaster;
Drosophila
melanogaster) 		5 / 12 LEU B 198
PHE B 194
LEU A  49
ILE B 245
VAL A  62
 None
 1.20A 3w1wA-3sipB:
undetectable		 3w1wA-3sipB:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3sip CASPASE
(Drosophila
melanogaster) 		4 / 8 LEU B 202
MET A  15
LEU B 253
ILE B 174
 None
 0.96A 4ok1A-3sipB:
undetectable		 4ok1A-3sipB:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3sip CASPASE
(Drosophila
melanogaster) 		4 / 8 THR B 247
LEU B 173
ILE B 211
LEU A 132
 None
 0.88A 5g48A-3sipB:
undetectable		 5g48A-3sipB:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3sip CASPASE
(Drosophila
melanogaster) 		4 / 6 LEU A  90
LEU B 249
LEU B 253
LEU B 215
 None
 0.92A 5gs4A-3sipA:
undetectable		 5gs4A-3sipA:
20.09