SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sir'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 9 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
 None
 1.23A 2vcvD-3sirA:
undetectable		 2vcvD-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 9 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
 None
 1.20A 2vcvE-3sirA:
undetectable		 2vcvE-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 9 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
 None
 1.17A 2vcvH-3sirA:
undetectable		 2vcvH-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 9 PHE A  58
LEU A 253
LEU A 215
LEU A 202
PHE A 134
 None
 1.14A 2vcvI-3sirA:
undetectable		 2vcvI-3sirA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 12 GLU A  29
TYR A  63
ILE A  93
SER A  95
HIS A  28
 None
 1.41A 3bwyA-3sirA:
undetectable		 3bwyA-3sirA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 12 LEU A  72
ILE A  71
TYR A  68
ALA A 137
SER A  95
 None
 1.43A 4a83A-3sirA:
undetectable		 4a83A-3sirA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3sir CASPASE
(Drosophila
melanogaster) 		4 / 8 LEU A 202
MET A  15
LEU A 253
ILE A 174
 None
 0.96A 4ok1A-3sirA:
undetectable		 4ok1A-3sirA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.41A 4qvlV-3sirA:
undetectable
4qvlb-3sirA:
undetectable		 4qvlV-3sirA:
20.91
4qvlb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qvmV-3sirA:
undetectable
4qvmb-3sirA:
undetectable		 4qvmV-3sirA:
20.91
4qvmb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qvmH-3sirA:
undetectable
4qvmN-3sirA:
undetectable		 4qvmH-3sirA:
20.91
4qvmN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.36A 4qvpV-3sirA:
undetectable
4qvpb-3sirA:
undetectable		 4qvpV-3sirA:
20.91
4qvpb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.37A 4qvpH-3sirA:
undetectable
4qvpN-3sirA:
undetectable		 4qvpH-3sirA:
20.91
4qvpN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.35A 4qvqV-3sirA:
undetectable
4qvqb-3sirA:
undetectable		 4qvqV-3sirA:
20.91
4qvqb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.36A 4qvqH-3sirA:
undetectable
4qvqN-3sirA:
undetectable		 4qvqH-3sirA:
20.91
4qvqN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qvwV-3sirA:
undetectable
4qvwb-3sirA:
undetectable		 4qvwV-3sirA:
20.91
4qvwb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qvwH-3sirA:
undetectable
4qvwN-3sirA:
undetectable		 4qvwH-3sirA:
20.91
4qvwN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.41A 4qw0V-3sirA:
undetectable
4qw0b-3sirA:
undetectable		 4qw0V-3sirA:
20.91
4qw0b-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qw0H-3sirA:
undetectable
4qw0N-3sirA:
undetectable		 4qw0H-3sirA:
20.91
4qw0N-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qw3V-3sirA:
undetectable
4qw3b-3sirA:
undetectable		 4qw3V-3sirA:
20.91
4qw3b-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 4qw3H-3sirA:
undetectable
4qw3N-3sirA:
undetectable		 4qw3H-3sirA:
20.91
4qw3N-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.37A 4qwuV-3sirA:
undetectable
4qwub-3sirA:
undetectable		 4qwuV-3sirA:
20.91
4qwub-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.37A 4qwuH-3sirA:
undetectable
4qwuN-3sirA:
undetectable		 4qwuH-3sirA:
20.91
4qwuN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3sir CASPASE
(Drosophila
melanogaster) 		4 / 7 MET A 195
PHE A 194
SER A 192
ALA A 137
 None
 1.03A 4xk8A-3sirA:
undetectable		 4xk8A-3sirA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.36A 5bxnV-3sirA:
undetectable
5bxnb-3sirA:
undetectable		 5bxnV-3sirA:
20.91
5bxnb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.39A 5bxnH-3sirA:
undetectable
5bxnN-3sirA:
undetectable		 5bxnH-3sirA:
20.91
5bxnN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 5cz7H-3sirA:
undetectable
5cz7N-3sirA:
undetectable		 5cz7H-3sirA:
20.91
5cz7N-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 5d0xV-3sirA:
undetectable
5d0xb-3sirA:
undetectable		 5d0xV-3sirA:
20.91
5d0xb-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.40A 5d0xH-3sirA:
undetectable
5d0xN-3sirA:
undetectable		 5d0xH-3sirA:
20.91
5d0xN-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.35A 5l66V-3sirA:
undetectable
5l66b-3sirA:
undetectable		 5l66V-3sirA:
20.91
5l66b-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 11 HIS A  28
SER A  95
GLY A 140
ALA A 137
THR A 178
 None
 1.34A 5l66H-3sirA:
undetectable
5l66N-3sirA:
undetectable		 5l66H-3sirA:
20.91
5l66N-3sirA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3sir CASPASE
(Drosophila
melanogaster) 		5 / 12 GLU A  29
TYR A  63
ILE A  93
SER A  95
HIS A  28
 None
 1.39A 5lsaA-3sirA:
undetectable		 5lsaA-3sirA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3sir CASPASE
(Drosophila
melanogaster) 		4 / 5 LEU A 215
LEU A 214
MET A 195
TYR A 176
 None
 1.32A 5uc3A-3sirA:
undetectable		 5uc3A-3sirA:
15.35