SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3siu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		3 / 3 LEU B 283
PRO B 284
LEU B 287
 None
 0.41A 2qd5B-3siuB:
undetectable		 2qd5B-3siuB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		5 / 12 ALA B 171
LEU B 142
ILE B 164
LEU B 159
THR B 174
 None
 1.11A 3fl9B-3siuB:
undetectable		 3fl9B-3siuB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		5 / 11 ALA B 171
LEU B 142
ILE B 164
LEU B 159
THR B 174
 None
 1.10A 3fl9C-3siuB:
undetectable		 3fl9C-3siuB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		5 / 9 ALA B 171
LEU B 142
ILE B 164
LEU B 159
THR B 174
 None
 1.19A 3fl9H-3siuB:
undetectable		 3fl9H-3siuB:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		3 / 3 LEU B 283
PRO B 284
LEU B 287
 None
 0.29A 3w1wB-3siuB:
undetectable		 3w1wB-3siuB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		5 / 11 ARG B 121
LEU B 142
ASP B 147
LEU B 146
LEU B 155
 None
 1.42A 4or0A-3siuB:
4.4		 4or0A-3siuB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		4 / 5 ASP B 134
ASN B 131
ASN B 198
ARG B 203
 None
 1.47A 5vooB-3siuB:
undetectable		 5vooB-3siuB:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31
(Homo
sapiens) 		3 / 3 GLY B 233
VAL B 208
MET B 212
 None
 0.62A 5ycpA-3siuB:
undetectable		 5ycpA-3siuB:
16.26