SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3siv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DB1_A_VDXA428_1 (VITAMIN D NUCLEAR RECEPTOR)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 22 LEU A 25 VAL A 26 SER A 29 VAL A 81	None	1.09A	1db1A-3sivA: undetectable	1db1A-3sivA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE9_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	LEU A 22 LEU A 25 VAL A 26 SER A 29 VAL A 81	None	1.10A	1ie9A-3sivA: undetectable	1ie9A-3sivA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_C_X2NC1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	PHE A 82 MET A 56 PRO A 12 ALA A 42 LEU A 71	None	1.34A	2x2nC-3sivA: undetectable	2x2nC-3sivA: 16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3C6G_B_VD3B700_1 (CYTOCHROME P450 2R1)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 39 ALA A 57 VAL A 83 THR A 105 THR A 45	U F 36 ( 3.1A) None None None None	1.07A	3c6gB-3sivA: undetectable	3c6gB-3sivA: 14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CZH_A_D2VA602_1 (CYTOCHROME P450 2R1)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 39 ALA A 57 VAL A 83 THR A 105 THR A 45	U F 36 ( 3.1A) None None None None	1.07A	3czhA-3sivA: undetectable	3czhA-3sivA: 14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CZH_B_D2VB602_1 (CYTOCHROME P450 2R1)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	5 / 12	ALA A 39 ALA A 57 VAL A 83 THR A 105 THR A 45	U F 36 ( 3.1A) None None None None	1.06A	3czhB-3sivA: undetectable	3czhB-3sivA: 14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ACB_C_DXCC1479_0 (TRANSLATION ELONGATION FACTOR SELB)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	4 / 5	THR A 105 ILE A 106 LYS A 107 GLU A 108	None	1.18A	4acbC-3sivA: undetectable	4acbC-3sivA: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LJ0_A_ACTA505_0 (NAB2)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	3 / 3	LEU A 23 LYS A 20 THR A 19	None	0.50A	4lj0A-3sivA: undetectable	4lj0A-3sivA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_E_IPHE101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	3siv	NHP2-LIKE PROTEIN 1 (Homo sapiens)	4 / 7	CYH A 73 LEU A 46 ALA A 42 HIS A 68	None	0.96A	5hrqE-3sivA: undetectable 5hrqF-3sivA: undetectable 5hrqJ-3sivA: undetectable	5hrqE-3sivA: 10.00 5hrqF-3sivA: 12.73 5hrqJ-3sivA: 12.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DB1_A_VDXA428_1","VITAMIN D NUCLEAR RECEPTOR","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"LEU A  22;LEU A  25;VAL A  26;SER A  29;VAL A  81","None","1.09A","1db1A-3sivA:undetectable","1db1A-3sivA:18.97"],["1IE9_A_VDXA500_1","VITAMIN D3 RECEPTOR","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"LEU A  22;LEU A  25;VAL A  26;SER A  29;VAL A  81","None","1.10A","1ie9A-3sivA:undetectable","1ie9A-3sivA:18.97"],["2X2N_C_X2NC1479_1","LANOSTEROL 14-ALPHA-DEMETHYLASE","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"PHE A  82;MET A  56;PRO A  12;ALA A  42;LEU A  71","None","1.34A","2x2nC-3sivA:undetectable","2x2nC-3sivA:16.29"],["3C6G_B_VD3B700_1","CYTOCHROME P450 2R1","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"ALA A  39;ALA A  57;VAL A  83;THR A 105;THR A  45","  U F  36 ( 3.1A);None;None;None;None","1.07A","3c6gB-3sivA:undetectable","3c6gB-3sivA:14.05"],["3CZH_A_D2VA602_1","CYTOCHROME P450 2R1","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"ALA A  39;ALA A  57;VAL A  83;THR A 105;THR A  45","  U F  36 ( 3.1A);None;None;None;None","1.07A","3czhA-3sivA:undetectable","3czhA-3sivA:14.05"],["3CZH_B_D2VB602_1","CYTOCHROME P450 2R1","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",5,"ALA A  39;ALA A  57;VAL A  83;THR A 105;THR A  45","  U F  36 ( 3.1A);None;None;None;None","1.06A","3czhB-3sivA:undetectable","3czhB-3sivA:14.05"],["4ACB_C_DXCC1479_0","TRANSLATION ELONGATION FACTOR SELB","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",4,"THR A 105;ILE A 106;LYS A 107;GLU A 108","None","1.18A","4acbC-3sivA:undetectable","4acbC-3sivA:14.89"],["4LJ0_A_ACTA505_0","NAB2","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",3,"LEU A  23;LYS A  20;THR A  19","None","0.50A","4lj0A-3sivA:undetectable","4lj0A-3sivA:19.38"],["5HRQ_E_IPHE101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","3siv","NHP2-LIKE PROTEIN 1","Homo sapiens",4,"CYH A  73;LEU A  46;ALA A  42;HIS A  68","None","0.96A","5hrqE-3sivA:undetectable;5hrqF-3sivA:undetectable;5hrqJ-3sivA:undetectable","5hrqE-3sivA:10.00;5hrqF-3sivA:12.73;5hrqJ-3sivA:12.73"]]