SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 10 GLY A  17
LEU A  24
VAL A  31
ALA A  89
ASN A  87
 None
None
None
NDP  A 301 (-3.5A)
None
 1.18A 1fpqA-3sjuA:
6.7		 1fpqA-3sjuA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 GLU A 172
ILE A 178
ILE A 137
ARG A 130
THR A 176
 None
 1.42A 1kijA-3sjuA:
undetectable		 1kijA-3sjuA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 8 THR A 120
GLY A 115
THR A 114
VAL A 169
 None
 0.76A 2a1hA-3sjuA:
undetectable
2a1hB-3sjuA:
undetectable		 2a1hA-3sjuA:
21.98
2a1hB-3sjuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		3 / 3 ASP A 107
ASP A 101
ASN A  92
 None
 0.84A 2bm9D-3sjuA:
5.8		 2bm9D-3sjuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 7 ARG A 118
GLY A 115
SER A  64
GLU A  67
 None
 1.04A 2c8aB-3sjuA:
undetectable		 2c8aB-3sjuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 7 ARG A 118
GLY A 115
SER A  64
GLU A  67
 None
 1.05A 2c8aD-3sjuA:
undetectable		 2c8aD-3sjuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 GLY A 115
ASP A  61
GLY A  11
VAL A  72
VAL A  68
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
None
 0.92A 2ieoB-3sjuA:
undetectable		 2ieoB-3sjuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 THR A 190
VAL A 230
ALA A 231
VAL A   9
VAL A 138
 NDP  A 301 (-2.8A)
None
None
None
None
 0.97A 2nniA-3sjuA:
undetectable		 2nniA-3sjuA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 GLY A 115
ASP A  61
GLY A  11
VAL A  72
VAL A  68
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
None
 0.87A 2nnkA-3sjuA:
undetectable		 2nnkA-3sjuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 GLY A 115
ASP A  61
GLY A  11
VAL A  72
VAL A  68
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
None
 0.89A 2nnkB-3sjuA:
undetectable		 2nnkB-3sjuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 10 GLY A  57
GLY A  17
LEU A  18
SER A  14
ALA A  44
 None
None
None
NDP  A 301 (-3.0A)
None
 0.90A 2v3kA-3sjuA:
undetectable		 2v3kA-3sjuA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 8 ILE A 140
ASN A 112
SER A 158
SER A 142
 NDP  A 301 (-4.3A)
None
None
NDP  A 301 (-3.7A)
 1.09A 2zw9B-3sjuA:
undetectable		 2zw9B-3sjuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 VAL A  86
ILE A  84
VAL A   9
LEU A  24
THR A  23
 None
 1.06A 3fw3B-3sjuA:
undetectable		 3fw3B-3sjuA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 10 GLY A 115
ASP A  61
GLY A  11
VAL A  72
VAL A  68
 None
NDP  A 301 (-3.3A)
NDP  A 301 (-3.5A)
None
None
 0.95A 3nu9B-3sjuA:
undetectable		 3nu9B-3sjuA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 5 LEU A  24
GLY A 235
ILE A 140
VAL A 183
 None
None
NDP  A 301 (-4.3A)
None
 0.84A 3wriA-3sjuA:
undetectable		 3wriA-3sjuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 5 LEU A  24
GLY A 235
ILE A 140
VAL A 183
 None
None
NDP  A 301 (-4.3A)
None
 0.85A 3wriB-3sjuA:
undetectable		 3wriB-3sjuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		4 / 5 LEU A  24
GLY A 235
ILE A 140
VAL A 183
 None
None
NDP  A 301 (-4.3A)
None
 0.86A 3wrkA-3sjuA:
undetectable		 3wrkA-3sjuA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 GLU A 172
ILE A 178
ILE A 137
ARG A 130
THR A 176
 None
 1.39A 4uroD-3sjuA:
undetectable		 4uroD-3sjuA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		3 / 4 ARG A 130
GLY A 127
GLU A 131
 None
 0.61A 4z2dB-3sjuA:
undetectable
4z2dC-3sjuA:
2.6		 4z2dB-3sjuA:
21.41
4z2dC-3sjuA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 ALA A  71
SER A  58
PHE A   8
THR A 120
ARG A 121
 None
 1.33A 5m54B-3sjuA:
5.2		 5m54B-3sjuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3sju KETO REDUCTASE
(Streptomyces
griseoruber) 		5 / 12 ASP A  66
GLU A  67
ALA A  71
PHE A   8
ARG A 125
 None
 1.29A 5nd2B-3sjuA:
6.6		 5nd2B-3sjuA:
21.46