SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3skd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		3 / 3 ALA A  80
VAL A  77
TRP A 161
 None
 0.95A 1grmA-3skdA:
undetectable		 1grmA-3skdA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		3 / 3 ALA A  80
VAL A  77
TRP A 161
 None
 0.95A 1grmB-3skdA:
undetectable		 1grmB-3skdA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 9 LEU A  33
ALA A  64
GLY A 177
ALA A 178
LEU A  53
 None
 1.00A 1nr6A-3skdA:
undetectable		 1nr6A-3skdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 12 LEU A 237
PHE A 203
VAL A  35
PHE A 214
ALA A 208
 None
 1.39A 3u9fD-3skdA:
undetectable
3u9fE-3skdA:
undetectable		 3u9fD-3skdA:
21.77
3u9fE-3skdA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 12 LEU A 176
ALA A  64
MET A  25
LEU A  26
LEU A  22
 None
 1.10A 4j24D-3skdA:
undetectable		 4j24D-3skdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 12 LEU A 176
ALA A  64
MET A  25
LEU A  26
LEU A 169
 None
 1.09A 4j24D-3skdA:
undetectable		 4j24D-3skdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		3 / 3 LEU A 111
ARG A 165
ARG A 115
 None
 0.87A 4yiaB-3skdA:
undetectable		 4yiaB-3skdA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 12 LEU A  59
LEU A 176
VAL A  35
ALA A  34
LEU A 230
 None
 0.93A 5jw1B-3skdA:
undetectable		 5jw1B-3skdA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		4 / 7 LEU A 134
VAL A  35
TYR A  47
GLU A 255
 None
 1.25A 5umwA-3skdA:
undetectable
5umwF-3skdA:
undetectable		 5umwA-3skdA:
17.94
5umwF-3skdA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		5 / 12 ALA A 164
LEU A  71
ALA A   9
HIS A 153
LEU A 154
 None
 1.02A 6a60D-3skdA:
undetectable		 6a60D-3skdA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		3 / 3 HIS A  24
HIS A  19
ARG A 218
 NI  A 261 (-3.5A)
None
None
 0.92A 6b58A-3skdA:
undetectable		 6b58A-3skdA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		4 / 5 LEU A 230
LEU A 176
THR A  28
ARG A 196
 None
 1.08A 6ew0F-3skdA:
undetectable		 6ew0F-3skdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		4 / 6 LEU A 230
LEU A 176
THR A  28
ARG A 196
 None
 1.08A 6ew0G-3skdA:
undetectable		 6ew0G-3skdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187
(Thermus
thermophilus) 		3 / 3 ARG A 251
GLY A 254
GLU A 255
 None
 0.62A 6fgdA-3skdA:
undetectable		 6fgdA-3skdA:
22.01