SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sky'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 11 PHE A 442
ILE A 499
ALA A 418
LEU A 415
ALA A 437
 None
 1.45A 1jb0B-3skyA:
undetectable		 1jb0B-3skyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 433
ALA A 437
ARG A 514
VAL A 469
ILE A 499
 None
 1.08A 3falA-3skyA:
undetectable		 3falA-3skyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 11 PHE A 442
ILE A 499
ALA A 418
LEU A 415
ALA A 437
 None
 1.45A 3pcqB-3skyA:
undetectable		 3pcqB-3skyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_0
(MNMC2)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		6 / 12 GLY A 582
LEU A 615
GLY A 601
ALA A 590
PHE A 388
LEU A 536
 None
 1.44A 3vywC-3skyA:
undetectable		 3vywC-3skyA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 12 VAL A 596
LEU A 526
PHE A 388
LEU A 615
THR A 578
 None
 1.15A 4eckA-3skyA:
undetectable		 4eckA-3skyA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		4 / 8 ILE A 529
GLU A 628
ILE A 626
LEU A 629
 None
 0.93A 4mj8A-3skyA:
undetectable		 4mj8A-3skyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 10 ARG A 440
ALA A 418
GLY A 507
VAL A 401
ILE A 433
 None
 1.12A 4q1wB-3skyA:
undetectable		 4q1wB-3skyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 598
ILE A 600
LEU A 615
LEU A 394
VAL A 386
 None
 1.16A 5km9B-3skyA:
undetectable		 5km9B-3skyA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 624
LEU A 615
ILE A 600
VAL A 386
ASP A 612
 None
 1.30A 5vlmG-3skyA:
undetectable		 5vlmG-3skyA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3sky COPPER-EXPORTING
P-TYPE ATPASE B
(Archaeoglobus
fulgidus) 		4 / 6 LEU A 383
VAL A 386
LEU A 526
VAL A 581
 None
 0.86A 5x7zA-3skyA:
undetectable		 5x7zA-3skyA:
21.64