SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ASP A 325
SER A 326
ILE A 291
GLY A 219
 MN  A 412 ( 2.0A)
None
None
None
 0.76A 1me7A-3sl1A:
undetectable		 1me7A-3sl1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ASP A 325
SER A 326
ILE A 291
GLY A 219
 MN  A 412 ( 2.0A)
None
None
None
 0.73A 1meiA-3sl1A:
undetectable		 1meiA-3sl1A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 4 HIS A 193
ALA A 196
PHE A 197
GLY A 194
 MN  A 413 (-3.3A)
None
None
None
 1.37A 1mj2B-3sl1A:
undetectable		 1mj2B-3sl1A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 4 HIS A 193
ALA A 196
PHE A 197
GLY A 194
 MN  A 413 (-3.3A)
None
None
None
 1.38A 1mjoB-3sl1A:
undetectable		 1mjoB-3sl1A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 4 HIS A 193
ALA A 196
PHE A 197
GLY A 194
 MN  A 413 (-3.3A)
None
None
None
 1.38A 1mjoD-3sl1A:
undetectable		 1mjoD-3sl1A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASN A  68
ARG A  48
ILE A  66
GLY A  67
 None
 1.10A 1oniA-3sl1A:
undetectable
1oniB-3sl1A:
undetectable		 1oniA-3sl1A:
14.32
1oniB-3sl1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 7 ILE A  66
GLY A  67
ASN A 188
ARG A  48
 None
 0.98A 1oniG-3sl1A:
undetectable
1oniI-3sl1A:
undetectable		 1oniG-3sl1A:
14.32
1oniI-3sl1A:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bA-3sl1A:
2.3		 1v8bA-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bB-3sl1A:
2.3		 1v8bB-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 1v8bD-3sl1A:
undetectable		 1v8bD-3sl1A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 PRO A 371
GLY A 190
GLY A 191
ASP A 365
MET A 364
 None
 1.19A 1wg8A-3sl1A:
undetectable		 1wg8A-3sl1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 PRO A 371
GLY A 190
GLY A 191
ASP A 365
MET A 364
 None
 1.15A 1wg8B-3sl1A:
undetectable		 1wg8B-3sl1A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 319
SER A 363
HIS A 193
LEU A  47
ILE A 189
 None
None
MN  A 413 (-3.3A)
None
None
 1.44A 2fj1A-3sl1A:
undetectable		 2fj1A-3sl1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 334
SER A 372
THR A 335
GLY A 336
GLN A  35
 None
 1.00A 2hmaA-3sl1A:
undetectable		 2hmaA-3sl1A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 8 ILE A 215
ILE A 320
ILE A 200
ILE A 268
VAL A 361
 None
 0.88A 2nniA-3sl1A:
undetectable		 2nniA-3sl1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 3ce6D-3sl1A:
2.0		 3ce6D-3sl1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 VAL A 361
ILE A 310
ILE A 268
LEU A 351
ILE A 320
 None
 0.94A 3clbA-3sl1A:
undetectable		 3clbA-3sl1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 VAL A 361
ILE A 310
ILE A 268
LEU A 351
ILE A 320
 None
 0.95A 3clbC-3sl1A:
undetectable		 3clbC-3sl1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		3 / 3 SER A 229
GLU A 368
ASP A 365
 FB6  A 414 (-2.6A)
FB6  A 414 ( 3.9A)
None
 0.80A 3dmhA-3sl1A:
3.4		 3dmhA-3sl1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 3g1uB-3sl1A:
undetectable		 3g1uB-3sl1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.32A 3g1uD-3sl1A:
2.3		 3g1uD-3sl1A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 LEU A 237
THR A 265
ASP A 365
LEU A 201
HIS A 319
 None
 1.12A 3glqA-3sl1A:
undetectable		 3glqA-3sl1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 LEU A 237
THR A 265
ASP A 365
LEU A 201
HIS A 319
 None
 1.16A 3glqB-3sl1A:
2.0		 3glqB-3sl1A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		9 / 9 HIS A 218
ASP A 220
ASN A 222
SER A 229
HIS A 233
GLY A 234
ASP A 274
GLU A 277
THR A 337
 MN  A 412 ( 3.3A)
FB6  A 414 ( 2.6A)
FB6  A 414 (-4.0A)
FB6  A 414 (-2.6A)
FB6  A 414 (-3.5A)
FB6  A 414 (-3.6A)
FB6  A 414 (-2.9A)
FB6  A 414 ( 4.0A)
FB6  A 414 ( 4.2A)
 0.40A 3gn0A-3sl1A:
44.6		 3gn0A-3sl1A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_B_DMOB552_1
(ARGINASE-1)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		9 / 9 HIS A 218
ASP A 220
ASN A 222
SER A 229
HIS A 233
GLY A 234
ASP A 274
GLU A 277
THR A 337
 MN  A 412 ( 3.3A)
FB6  A 414 ( 2.6A)
FB6  A 414 (-4.0A)
FB6  A 414 (-2.6A)
FB6  A 414 (-3.5A)
FB6  A 414 (-3.6A)
FB6  A 414 (-2.9A)
FB6  A 414 ( 4.0A)
FB6  A 414 ( 4.2A)
 0.40A 3gn0B-3sl1A:
44.9		 3gn0B-3sl1A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3sl1 ARGINASE
(Plasmodium
falciparum) 		6 / 12 LEU A 187
ILE A 310
LEU A 355
VAL A 361
VAL A 405
ILE A 215
 None
 1.34A 3gwxB-3sl1A:
undetectable		 3gwxB-3sl1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 10 VAL A 361
ILE A 310
ILE A 268
LEU A 351
ILE A 320
 None
 0.94A 3hbbA-3sl1A:
undetectable		 3hbbA-3sl1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 VAL A 361
ILE A 310
ILE A 268
LEU A 351
ILE A 320
 None
 0.89A 3hbbC-3sl1A:
undetectable		 3hbbC-3sl1A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 219
THR A 236
GLU A 277
ASP A 216
ILE A 270
 None
None
FB6  A 414 ( 4.0A)
MN  A 413 (-2.6A)
None
 1.25A 3id5B-3sl1A:
3.6		 3id5B-3sl1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 219
THR A 236
GLU A 277
ASP A 216
ILE A 270
 None
None
FB6  A 414 ( 4.0A)
MN  A 413 (-2.6A)
None
 1.25A 3id5F-3sl1A:
undetectable		 3id5F-3sl1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 LEU A 237
THR A 265
ASP A 365
LEU A 201
HIS A 319
 None
 1.09A 3n58A-3sl1A:
3.0		 3n58A-3sl1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 3n58C-3sl1A:
3.1		 3n58C-3sl1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 LEU A 237
THR A 265
ASP A 365
LEU A 201
HIS A 319
 None
 1.14A 3n58D-3sl1A:
2.2		 3n58D-3sl1A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 3ondA-3sl1A:
2.2		 3ondA-3sl1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 3ondB-3sl1A:
3.1		 3ondB-3sl1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 10 ALA A 332
ILE A 320
LEU A 401
ILE A 294
ILE A 270
 None
 1.15A 3prsA-3sl1A:
undetectable		 3prsA-3sl1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 10 MET A 364
LEU A 399
LEU A 397
MET A 352
LEU A 406
 None
 1.38A 3uudB-3sl1A:
undetectable		 3uudB-3sl1A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ILE A  69
ASN A  68
GLY A  67
ILE A  66
 None
 0.89A 3wxoA-3sl1A:
undetectable		 3wxoA-3sl1A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 GLY A 269
ILE A 299
ILE A 354
LEU A 355
ILE A 303
 None
 1.01A 4dt8A-3sl1A:
undetectable		 4dt8A-3sl1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 7 ASP A 274
ASP A 323
ASP A 220
GLU A 277
 FB6  A 414 (-2.9A)
MN  A 412 (-2.8A)
FB6  A 414 ( 2.6A)
FB6  A 414 ( 4.0A)
 1.22A 4gkhG-3sl1A:
undetectable		 4gkhG-3sl1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 274
ASP A 323
ASP A 220
GLU A 277
 FB6  A 414 (-2.9A)
MN  A 412 (-2.8A)
FB6  A 414 ( 2.6A)
FB6  A 414 ( 4.0A)
 1.26A 4gkhJ-3sl1A:
undetectable		 4gkhJ-3sl1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 PRO A  30
ARG A  48
GLY A  67
PHE A 168
LEU A 172
 None
 1.31A 4kotA-3sl1A:
undetectable		 4kotA-3sl1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 10 PRO A  30
ARG A  48
GLY A  67
PHE A 168
LEU A 172
 None
 1.28A 4kouA-3sl1A:
undetectable		 4kouA-3sl1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 PRO A  30
ARG A  48
GLY A  67
PHE A 168
LEU A 172
 None
 1.29A 4kovA-3sl1A:
undetectable		 4kovA-3sl1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOX_A_CLSA205_1
(UNCHARACTERIZED
PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 PRO A  30
ARG A  48
GLY A  67
PHE A 168
LEU A 172
 None
 1.31A 4koxA-3sl1A:
undetectable		 4koxA-3sl1A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		3 / 3 ASP A 216
ASP A 220
ASN A 231
 MN  A 413 (-2.6A)
FB6  A 414 ( 2.6A)
None
 0.83A 4q5mA-3sl1A:
undetectable		 4q5mA-3sl1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.42A 4w5rA-3sl1A:
4.4		 4w5rA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.43A 4w5tA-3sl1A:
4.4		 4w5tA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 LEU A  31
ASP A 365
GLU A 368
ILE A 162
 None
None
FB6  A 414 ( 3.9A)
None
 0.95A 4xi3C-3sl1A:
undetectable		 4xi3C-3sl1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.39A 4z4cA-3sl1A:
4.4		 4z4cA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.38A 4z4fA-3sl1A:
4.2		 4z4fA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 5 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.41A 4z4gA-3sl1A:
4.5		 4z4gA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 6 ASP A 293
THR A 302
THR A 305
TYR A 289
 None
 1.40A 4z4iA-3sl1A:
4.3		 4z4iA-3sl1A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 7 GLY A 194
ASP A 192
GLU A 164
SER A 227
 None
None
None
FB6  A 414 ( 4.3A)
 0.94A 4z53A-3sl1A:
2.5
4z53B-3sl1A:
2.3		 4z53A-3sl1A:
21.38
4z53B-3sl1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5axdA-3sl1A:
2.6		 5axdA-3sl1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5axdC-3sl1A:
2.7		 5axdC-3sl1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 ASP A 374
HIS A 233
ASP A 220
HIS A 218
ASP A 216
 None
FB6  A 414 (-3.5A)
FB6  A 414 ( 2.6A)
MN  A 412 ( 3.3A)
MN  A 413 (-2.6A)
 1.19A 5ef8B-3sl1A:
13.0		 5ef8B-3sl1A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		3 / 3 ASN A 349
ASP A 383
GLY A 382
 None
 0.45A 5fctB-3sl1A:
undetectable		 5fctB-3sl1A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 11 MET A 364
LEU A 399
LEU A 397
MET A 352
LEU A 406
 None
 1.35A 5hyrB-3sl1A:
undetectable		 5hyrB-3sl1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 ILE A 318
ILE A 213
VAL A 361
ASN A 188
ASP A 365
 None
 1.20A 5lg3J-3sl1A:
undetectable		 5lg3J-3sl1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.21A 5m5kB-3sl1A:
3.1		 5m5kB-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.29A 5m66A-3sl1A:
2.7		 5m66A-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.28A 5m66C-3sl1A:
2.8		 5m66C-3sl1A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.27A 5utuF-3sl1A:
2.1		 5utuF-3sl1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 ALA A  43
ILE A  27
VAL A 195
ASP A  70
PHE A 168
 None
 1.27A 5vlmG-3sl1A:
undetectable		 5vlmG-3sl1A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_1
(-)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		5 / 12 HIS A 218
ASP A 325
THR A 335
GLY A 234
HIS A 233
 MN  A 412 ( 3.3A)
MN  A 412 ( 2.0A)
None
FB6  A 414 (-3.6A)
FB6  A 414 (-3.5A)
 1.24A 6f3nB-3sl1A:
undetectable		 6f3nB-3sl1A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ASP A  65
ILE A  27
ARG A  48
ASN A 171
 None
 1.18A 6hisA-3sl1A:
undetectable
6hisB-3sl1A:
undetectable		 6hisA-3sl1A:
11.76
6hisB-3sl1A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ASP A  65
ILE A  27
ARG A  48
ASN A 171
 None
 1.17A 6hisB-3sl1A:
undetectable
6hisC-3sl1A:
undetectable		 6hisB-3sl1A:
11.76
6hisC-3sl1A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3sl1 ARGINASE
(Plasmodium
falciparum) 		4 / 8 ASP A  65
ILE A  27
ARG A  48
ASN A 171
 None
 1.17A 6hisD-3sl1A:
undetectable
6hisE-3sl1A:
undetectable		 6hisD-3sl1A:
11.76
6hisE-3sl1A:
11.76