SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		5 / 9 ASN A 503
ASP A 533
ILE A 538
PRO A 539
THR A 592
 MG  A 701 ( 2.5A)
ATP  A 703 (-3.5A)
ATP  A 703 (-4.5A)
None
ATP  A 703 (-3.9A)
 0.59A 1aj6A-3sl2A:
6.2		 1aj6A-3sl2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		5 / 12 ASN A 503
ASP A 533
ILE A 538
PRO A 539
THR A 592
 MG  A 701 ( 2.5A)
ATP  A 703 (-3.5A)
ATP  A 703 (-4.5A)
None
ATP  A 703 (-3.9A)
 0.76A 1kijB-3sl2A:
undetectable		 1kijB-3sl2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		4 / 7 ILE A 536
GLY A 537
PRO A 509
ASN A 503
 None
ATP  A 703 (-4.3A)
None
MG  A 701 ( 2.5A)
 0.88A 1oniG-3sl2A:
undetectable
1oniI-3sl2A:
undetectable		 1oniG-3sl2A:
20.88
1oniI-3sl2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		5 / 11 ILE A 500
PHE A 596
ILE A 454
LEU A 497
THR A 593
 None
 1.15A 3qg2B-3sl2A:
undetectable		 3qg2B-3sl2A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		4 / 6 ILE A 570
ILE A 529
LEU A 598
HIS A 578
 None
 1.04A 5vkqA-3sl2A:
undetectable
5vkqB-3sl2A:
undetectable		 5vkqA-3sl2A:
7.01
5vkqB-3sl2A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		4 / 6 ILE A 570
ILE A 529
LEU A 598
HIS A 578
 None
 1.03A 5vkqC-3sl2A:
undetectable
5vkqD-3sl2A:
undetectable		 5vkqC-3sl2A:
7.01
5vkqD-3sl2A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sl2 SENSOR HISTIDINE
KINASE YYCG
(Bacillus
subtilis) 		4 / 6 ILE A 570
ILE A 529
LEU A 598
HIS A 578
 None
 1.03A 5vkqA-3sl2A:
undetectable
5vkqD-3sl2A:
undetectable		 5vkqA-3sl2A:
7.01
5vkqD-3sl2A:
7.01