SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3slt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 SER A1102
VAL A1126
SER A1148
ASP A1014
 None
 1.24A 1hwiB-3sltA:
undetectable		 1hwiB-3sltA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 SER A1102
VAL A1126
SER A1148
ASP A1014
 None
 1.22A 1hwkA-3sltA:
undetectable		 1hwkA-3sltA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 SER A1102
VAL A1126
SER A1148
ASP A1014
 None
 1.21A 1hwkC-3sltA:
undetectable		 1hwkC-3sltA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 SER A1102
VAL A1126
SER A1148
ASP A1014
 None
 1.19A 1hwkD-3sltA:
undetectable		 1hwkD-3sltA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 GLY A1104
THR A1085
GLY A1066
GLN A1064
 None
 0.72A 1jr1B-3sltA:
undetectable		 1jr1B-3sltA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 ASN A1130
PHE A1096
VAL A1013
 None
 0.84A 1kijA-3sltA:
undetectable		 1kijA-3sltA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 4 HIS A1127
ASP A1088
SER A1090
ASP A1129
 None
 1.03A 1n2xA-3sltA:
undetectable		 1n2xA-3sltA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 PRO A1201
GLY A1284
LEU A1173
VAL A1174
LEU A1019
 None
C8E  A1301 ( 4.4A)
None
None
None
 1.17A 1r30A-3sltA:
undetectable		 1r30A-3sltA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 PRO A1201
GLY A1284
LEU A1173
VAL A1174
LEU A1019
 None
C8E  A1301 ( 4.4A)
None
None
None
 1.17A 1r30B-3sltA:
undetectable		 1r30B-3sltA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 THR A1083
GLU A1021
HIS A1086
 None
 0.90A 1xwfA-3sltA:
undetectable		 1xwfA-3sltA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 THR A1083
GLU A1021
HIS A1086
 None
 0.90A 1xwfB-3sltA:
undetectable		 1xwfB-3sltA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 THR A1083
GLU A1021
HIS A1086
 None
 0.90A 1xwfC-3sltA:
undetectable		 1xwfC-3sltA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 THR A1083
GLU A1021
HIS A1086
 None
 0.89A 1xwfD-3sltA:
undetectable		 1xwfD-3sltA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 PHE A1296
ASN A1295
GLY A1030
THR A1222
 None
 0.92A 1ykiA-3sltA:
undetectable
1ykiB-3sltA:
undetectable		 1ykiA-3sltA:
22.80
1ykiB-3sltA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 THR A1222
PHE A1296
ASN A1295
GLY A1030
 None
 0.91A 1ykiA-3sltA:
undetectable
1ykiB-3sltA:
undetectable		 1ykiA-3sltA:
22.80
1ykiB-3sltA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 PHE A1296
ASN A1295
GLY A1030
THR A1222
 None
 0.92A 1ykiC-3sltA:
undetectable
1ykiD-3sltA:
undetectable		 1ykiC-3sltA:
22.80
1ykiD-3sltA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 THR A1222
PHE A1296
ASN A1295
GLY A1030
 None
 0.93A 1ykiC-3sltA:
undetectable
1ykiD-3sltA:
undetectable		 1ykiC-3sltA:
22.80
1ykiD-3sltA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
GLU A1172
GLU A1154
TYR A1118
 None
 1.35A 2cmlA-3sltA:
undetectable		 2cmlA-3sltA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
GLU A1172
GLU A1154
TYR A1118
 None
 1.33A 2cmlB-3sltA:
undetectable		 2cmlB-3sltA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
GLU A1172
GLU A1154
TYR A1118
 None
 1.33A 2cmlC-3sltA:
undetectable		 2cmlC-3sltA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 6 TRP A1042
MET A1029
MET A1112
LEU A1025
 None
 1.38A 2oz7A-3sltA:
undetectable		 2oz7A-3sltA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 ASN A1295
ARG A1044
ASP A1120
 None
 0.96A 2qe6A-3sltA:
undetectable		 2qe6A-3sltA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 ASN A1295
ARG A1044
ASP A1120
 None
 0.91A 2qe6B-3sltA:
undetectable		 2qe6B-3sltA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 TYR A1132
SER A1089
HIS A1128
SER A1102
 None
 1.31A 2vmyA-3sltA:
undetectable
2vmyB-3sltA:
undetectable		 2vmyA-3sltA:
23.94
2vmyB-3sltA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 PHE A1136
ALA A1008
THR A1239
LEU A1241
 None
 0.91A 3t3sC-3sltA:
undetectable		 3t3sC-3sltA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
GLU A1172
GLU A1154
TYR A1118
 None
 1.35A 4b7qA-3sltA:
undetectable		 4b7qA-3sltA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
SER A1023
GLU A1172
TYR A1118
 None
 1.17A 4b7qA-3sltA:
undetectable		 4b7qA-3sltA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
SER A1023
GLU A1172
TYR A1118
 None
 1.21A 4b7qB-3sltA:
undetectable		 4b7qB-3sltA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		5 / 12 ARG A1033
GLU A1168
GLU A1172
GLU A1154
TYR A1118
 None
 1.29A 4cpzC-3sltA:
undetectable		 4cpzC-3sltA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 8 ALA A1134
LEU A1010
ARG A1142
TYR A1144
 None
 1.12A 4ijiF-3sltA:
undetectable		 4ijiF-3sltA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		4 / 7 ARG A1205
GLN A1170
GLU A1168
ARG A1224
 None
 1.32A 4mv7A-3sltA:
undetectable		 4mv7A-3sltA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 3slt SERINE PROTEASE ESPP
(Escherichia
coli) 		3 / 3 TRP A1166
GLU A1168
ASP A1031
 None
 0.96A 5gqbA-3sltA:
undetectable		 5gqbA-3sltA:
22.06