SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3slu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 ALA A 302
ILE A 331
THR A 339
LEU A 340
LEU A 344
 None
 1.20A 1eiiA-3sluA:
undetectable		 1eiiA-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 10 ALA A 342
TYR A 325
LEU A 340
TYR A 341
HIS A 343
 None
 1.43A 1jglH-3sluA:
undetectable
1jglL-3sluA:
undetectable		 1jglH-3sluA:
20.95
1jglL-3sluA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W2Z_A_CUA701_0
(AMINE OXIDASE,
COPPER CONTAINING)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		3 / 3 HIS A 343
HIS A 373
HIS A 375
 None
None
NI  A   1 (-3.2A)
 0.71A 1w2zA-3sluA:
undetectable		 1w2zA-3sluA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 8 VAL A  77
VAL A  68
LEU A  78
HIS A 103
 None
 1.02A 2ddwA-3sluA:
undetectable		 2ddwA-3sluA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.31A 2rctA-3sluA:
undetectable		 2rctA-3sluA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 11 HIS A 343
GLU A 377
VAL A 308
GLY A 297
ILE A 298
 None
 1.14A 2uxpB-3sluA:
undetectable		 2uxpB-3sluA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z71_C_PNVC904_1
(PENICILLIN ACYLASE)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 10 GLY A 131
ARG A 379
THR A 127
ASN A 134
ASP A 128
 None
 1.39A 2z71A-3sluA:
0.0
2z71C-3sluA:
0.0		 2z71A-3sluA:
20.97
2z71C-3sluA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 6 SER A 311
ALA A 310
HIS A 333
ASP A 313
 None
 1.14A 3aruA-3sluA:
undetectable		 3aruA-3sluA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 5 HIS A 373
HIS A 343
ASP A 299
HIS A 375
 None
None
NI  A   1 (-2.5A)
NI  A   1 (-3.2A)
 0.99A 3c0zA-3sluA:
undetectable		 3c0zA-3sluA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 6 HIS A 373
HIS A 343
ASP A 299
HIS A 375
 None
None
NI  A   1 (-2.5A)
NI  A   1 (-3.2A)
 1.01A 3c0zC-3sluA:
undetectable		 3c0zC-3sluA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		3 / 3 GLU A 139
GLU A 122
TRP A 145
 None
 1.30A 3hrdA-3sluA:
undetectable
3hrdE-3sluA:
undetectable
3hrdF-3sluA:
undetectable		 3hrdA-3sluA:
23.52
3hrdE-3sluA:
23.52
3hrdF-3sluA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		3 / 3 ALA A  89
ARG A  90
LYS A 140
 None
 1.00A 3kp3B-3sluA:
undetectable		 3kp3B-3sluA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 GLY A 250
GLY A 251
ASP A 299
VAL A 308
LEU A 272
 None
None
NI  A   1 (-2.5A)
None
None
 0.84A 3m6wA-3sluA:
undetectable		 3m6wA-3sluA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 6 SER A 211
LEU A 157
THR A 159
ARG A 161
 None
 1.16A 3thrB-3sluA:
undetectable		 3thrB-3sluA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 7 ARG A 379
ALA A 378
HIS A 375
GLY A 297
 None
None
NI  A   1 (-3.2A)
None
 0.88A 3v4tH-3sluA:
undetectable		 3v4tH-3sluA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		3 / 3 PRO A 387
TYR A 376
GLY A 297
 None
 0.69A 4g2zA-3sluA:
undetectable		 4g2zA-3sluA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 GLY A 119
GLY A 115
ILE A  91
THR A  92
LEU A  78
 None
 1.06A 4n48A-3sluA:
undetectable		 4n48A-3sluA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 6 VAL A 230
SER A 162
ALA A 226
PHE A 239
 None
 1.20A 4nedA-3sluA:
undetectable		 4nedA-3sluA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.33A 4qynA-3sluA:
undetectable		 4qynA-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 12 PHE A 190
ILE A 224
ALA A 238
LEU A 207
LEU A 199
 None
 1.17A 4qzuC-3sluA:
undetectable		 4qzuC-3sluA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		5 / 11 ALA A 400
TYR A 254
TYR A 241
SER A 243
GLY A 250
 None
 0.98A 4xp4A-3sluA:
undetectable		 4xp4A-3sluA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3slu M23 PEPTIDASE DOMAIN
PROTEIN
(Neisseria
meningitidis) 		4 / 5 PRO A 384
VAL A 385
ALA A 378
PHE A 281
 None
 1.26A 4z4cA-3sluA:
undetectable		 4z4cA-3sluA:
17.97