SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sm3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 ILE A  37
GLY A  38
GLY A  40
SER A  41
ILE A  44
 None
 0.60A 1vq1B-3sm3A:
12.8		 1vq1B-3sm3A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 7 GLY A 143
SER A 167
PHE A 185
GLU A 164
 None
 0.92A 2c8aB-3sm3A:
undetectable		 2c8aB-3sm3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 7 GLY A 143
SER A 167
PHE A 185
GLU A 164
 None
 0.92A 2c8aD-3sm3A:
undetectable		 2c8aD-3sm3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ILE A  60
ASN A  91
ALA A  92
 None
 0.70A 2vdvE-3sm3A:
5.5		 2vdvE-3sm3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 11 GLY A  38
GLY A  40
ILE A  60
ASN A  91
ALA A  92
 None
 0.70A 2vdvF-3sm3A:
5.5		 2vdvF-3sm3A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ILE A  60
ASN A  91
ALA A  92
 None
 0.67A 3ckkA-3sm3A:
13.3		 3ckkA-3sm3A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 11 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.62A 3g88A-3sm3A:
15.7		 3g88A-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 11 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.60A 3g88B-3sm3A:
15.7		 3g88B-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.58A 3g89A-3sm3A:
15.7		 3g89A-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 11 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.57A 3g89B-3sm3A:
15.7		 3g89B-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.59A 3g8bA-3sm3A:
15.7		 3g8bA-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ASP A  59
ALA A  92
ALA A 109
 None
 0.54A 3g8bB-3sm3A:
13.8		 3g8bB-3sm3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 PHE A 220
LEU A 190
ILE A 124
SER A 121
LEU A 139
 None
 1.18A 3nrrA-3sm3A:
undetectable		 3nrrA-3sm3A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		6 / 11 ASP A  36
GLY A  38
GLY A  40
ILE A  44
ASP A  59
ASN A  91
 None
 0.62A 4dcmA-3sm3A:
13.2		 4dcmA-3sm3A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 5 SER A 121
LYS A 118
ARG A 120
LEU A 193
 None
 1.45A 4ifxA-3sm3A:
undetectable		 4ifxA-3sm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 5 SER A 121
LYS A 118
ARG A 120
LEU A 193
 None
 1.46A 4ig1A-3sm3A:
undetectable		 4ig1A-3sm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		3 / 3 ARG A 152
LYS A 153
LYS A 149
 None
 1.03A 4k50A-3sm3A:
undetectable		 4k50A-3sm3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		3 / 3 ARG A 152
LYS A 153
LYS A 149
 None
 1.10A 4k50E-3sm3A:
undetectable		 4k50E-3sm3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		3 / 3 ARG A 152
LYS A 153
LYS A 149
 None
 1.08A 4k50I-3sm3A:
undetectable		 4k50I-3sm3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 6 LEU A 139
PHE A 220
HIS A 183
GLU A 189
 None
 0.88A 4pahA-3sm3A:
undetectable		 4pahA-3sm3A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ILE A  44
ILE A  60
ASN A  61
 None
 0.75A 5fa8A-3sm3A:
13.2		 5fa8A-3sm3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		5 / 12 GLY A  38
GLY A  40
ILE A  60
ASN A  61
ASN A  91
 None
 0.92A 5fa8A-3sm3A:
13.2		 5fa8A-3sm3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 6 PHE A 168
ARG A 171
THR A 178
ILE A 181
 None
 1.13A 5ih0A-3sm3A:
undetectable		 5ih0A-3sm3A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		3 / 3 GLY A  40
ASP A  59
ASN A  91
 None
 0.33A 5jglA-3sm3A:
19.4		 5jglA-3sm3A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 7 THR A 112
HIS A 184
PHE A 168
THR A 213
 None
 1.14A 5u6mA-3sm3A:
2.4		 5u6mA-3sm3A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3sm3 SAM-DEPENDENT
METHYLTRANSFERASES
(Methanosarcina
mazei) 		4 / 7 THR A 112
HIS A 184
PHE A 168
THR A 213
 None
 1.28A 5u6mB-3sm3A:
3.5		 5u6mB-3sm3A:
18.68