SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sm9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6A_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 10 ILE A 365
ALA A  46
GLU A  53
TYR A 359
GLU A 362
 None
 1.39A 1n6aA-3sm9A:
0.0		 1n6aA-3sm9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 136
ALA A 133
GLN A 143
SER A 129
LEU A  19
 None
 1.39A 2aa5B-3sm9A:
undetectable		 2aa5B-3sm9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ILE A 130
SER A 127
ASP A  77
SER A  84
 None
None
SO4  A 481 (-4.3A)
None
 0.96A 2cdqA-3sm9A:
undetectable		 2cdqA-3sm9A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 9 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.93A 2idwB-3sm9A:
undetectable		 2idwB-3sm9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 7 GLY A 437
THR A 165
MET A 438
SER A 427
 None
 1.11A 2o5yH-3sm9A:
undetectable
2o5yL-3sm9A:
undetectable		 2o5yH-3sm9A:
17.51
2o5yL-3sm9A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ILE A  22
LEU A  48
VAL A  15
HIS A  69
LEU A  71
 None
 0.93A 2qo5A-3sm9A:
undetectable		 2qo5A-3sm9A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		3 / 3 ARG A 257
GLU A 289
TYR A 455
 None
 0.95A 3k37B-3sm9A:
undetectable		 3k37B-3sm9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.94A 3ndtC-3sm9A:
undetectable		 3ndtC-3sm9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.85A 3nduA-3sm9A:
undetectable		 3nduA-3sm9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.91A 3nduC-3sm9A:
undetectable		 3nduC-3sm9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.94A 3pwrB-3sm9A:
undetectable		 3pwrB-3sm9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ALA A  80
LEU A 135
ILE A 117
GLY A  17
HIS A  69
 None
 1.03A 3q95A-3sm9A:
undetectable		 3q95A-3sm9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A  80
ILE A 117
GLY A  17
HIS A  69
 None
 0.99A 3q95B-3sm9A:
undetectable		 3q95B-3sm9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		3 / 3 GLU A  37
PHE A 329
GLN A  42
 None
 1.00A 3r55A-3sm9A:
undetectable		 3r55A-3sm9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.96A 3tkgA-3sm9A:
undetectable		 3tkgA-3sm9A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 169
ASP A 276
GLU A 299
 None
Z99  A 485 ( 4.5A)
Z99  A 485 ( 3.8A)
None
 1.11A 4gkhC-3sm9A:
undetectable
4gkhK-3sm9A:
undetectable		 4gkhC-3sm9A:
19.62
4gkhK-3sm9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A  38
ASP A 169
ASP A 276
GLU A 299
 None
Z99  A 485 ( 4.5A)
Z99  A 485 ( 3.8A)
None
 1.10A 4gkiE-3sm9A:
undetectable
4gkiG-3sm9A:
undetectable		 4gkiE-3sm9A:
19.62
4gkiG-3sm9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 LEU A 136
VAL A 120
MET A  47
PHE A  20
THR A  73
 None
None
None
None
CL  A 486 (-3.1A)
 1.30A 4iaqA-3sm9A:
undetectable		 4iaqA-3sm9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 ILE A 365
ALA A  46
GLU A  53
TYR A 359
GLU A 362
 None
 1.38A 4j83A-3sm9A:
undetectable		 4j83A-3sm9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 ILE A 365
ALA A  46
GLU A  53
TYR A 359
GLU A 362
 None
 1.22A 4jdsD-3sm9A:
undetectable		 4jdsD-3sm9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 VAL A 191
VAL A 234
ILE A 235
TRP A 272
 None
 0.94A 4jq1B-3sm9A:
undetectable		 4jq1B-3sm9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PL1_A_SAMA401_0
(DUAL-SPECIFICITY RNA
METHYLTRANSFERASE
RLMN)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 PHE A 162
PRO A  21
SER A 148
ILE A 130
ASN A 134
 None
CL  A 486 ( 3.9A)
Z99  A 485 (-4.6A)
None
SO4  A 480 (-3.4A)
 1.36A 4pl1A-3sm9A:
1.9		 4pl1A-3sm9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 LEU A  81
ALA A  80
ILE A 117
GLY A  17
HIS A  69
 None
 1.02A 4pxmB-3sm9A:
undetectable		 4pxmB-3sm9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 9 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.92A 4rvjB-3sm9A:
undetectable		 4rvjB-3sm9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 9 LEU A  61
GLY A  67
ASP A  52
ILE A 121
ILE A  54
 None
 0.92A 4rvjD-3sm9A:
undetectable		 4rvjD-3sm9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 11 ILE A  51
ALA A  50
PHE A 415
TYR A 373
VAL A 369
 None
 1.32A 5hw4B-3sm9A:
2.6		 5hw4B-3sm9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 6 ASP A  38
ILE A 365
TYR A 146
TYR A 125
 None
None
None
Z99  A 485 ( 4.2A)
 1.30A 5igyA-3sm9A:
undetectable		 5igyA-3sm9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ILE A  51
GLY A  67
TYR A 373
ALA A  50
MET A  47
 None
 1.21A 5n0wA-3sm9A:
3.0		 5n0wA-3sm9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ILE A  51
GLY A  67
TYR A 373
ALA A  50
MET A  47
 None
 1.22A 5n0xB-3sm9A:
3.0		 5n0xB-3sm9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 ASP A 401
LEU A  61
ALA A 118
PRO A 142
LEU A 410
 None
 1.43A 5syfB-3sm9A:
5.3		 5syfB-3sm9A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		5 / 12 PHE A 431
PHE A 415
ALA A 417
ALA A  50
ILE A  51
 None
 1.08A 5veuB-3sm9A:
undetectable		 5veuB-3sm9A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3sm9 METABOTROPIC
GLUTAMATE RECEPTOR 3
(Homo
sapiens) 		4 / 8 ASP A 276
ARG A  39
GLU A 362
VAL A 368
 Z99  A 485 ( 3.8A)
Z99  A 485 (-3.8A)
None
None
 1.27A 6fbvD-3sm9A:
0.0		 6fbvD-3sm9A:
16.18