SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 TRP A 100
VAL A 102
TRP A  99
 None
 1.50A 1gmkC-3smaA:
undetectable
1gmkD-3smaA:
undetectable		 1gmkC-3smaA:
5.47
1gmkD-3smaA:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 ALA A  46
LEU A  48
VAL A  44
LEU A  65
VAL A  22
 None
ACO  A 300 (-4.0A)
None
None
None
 1.05A 1sn5B-3smaA:
undetectable
1sn5D-3smaA:
undetectable		 1sn5B-3smaA:
18.25
1sn5D-3smaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 LEU A  65
VAL A  22
ALA A  46
LEU A  48
VAL A  44
 None
None
None
ACO  A 300 (-4.0A)
None
 1.05A 1sn5B-3smaA:
undetectable
1sn5D-3smaA:
undetectable		 1sn5B-3smaA:
18.25
1sn5D-3smaA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 LEU A 180
LEU A 260
SER A 249
 None
 0.48A 1tlmA-3smaA:
undetectable		 1tlmA-3smaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 VAL A 172
PHE A 186
ALA A 270
PHE A 266
TYR A 261
 None
 1.45A 3apxA-3smaA:
undetectable		 3apxA-3smaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 7 LEU A 180
ALA A 258
LEU A 260
SER A 249
 None
 0.64A 3cfqA-3smaA:
undetectable
3cfqB-3smaA:
undetectable		 3cfqA-3smaA:
18.35
3cfqB-3smaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 CYH A 241
PRO A 246
ASP A 268
 None
 0.92A 3hlwB-3smaA:
undetectable		 3hlwB-3smaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 LEU A 181
ARG A 250
THR A 190
SER A 191
LEU A 242
 None
None
ACO  A 300 (-3.7A)
None
None
 1.34A 3okxA-3smaA:
undetectable		 3okxA-3smaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 LEU A 181
ARG A 250
THR A 190
SER A 191
LEU A 242
 None
None
ACO  A 300 (-3.7A)
None
None
 1.29A 3okxB-3smaA:
undetectable		 3okxB-3smaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 8 VAL A 211
VAL A 213
ASP A 226
GLN A 224
 None
 1.11A 3uy4A-3smaA:
undetectable		 3uy4A-3smaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 ARG A 278
HIS A 277
MET A 237
ASP A 233
 None
 1.32A 4cevA-3smaA:
undetectable
4cevB-3smaA:
undetectable		 4cevA-3smaA:
24.31
4cevB-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 5 ARG A 278
HIS A 277
MET A 237
ASP A 233
 None
 1.29A 4cevB-3smaA:
0.0
4cevC-3smaA:
0.0		 4cevB-3smaA:
24.31
4cevC-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 MET A 237
ASP A 233
ARG A 278
HIS A 277
 None
 1.30A 4cevA-3smaA:
undetectable
4cevC-3smaA:
undetectable		 4cevA-3smaA:
24.31
4cevC-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 ARG A 278
HIS A 277
MET A 237
ASP A 233
 None
 1.28A 4cevD-3smaA:
undetectable
4cevE-3smaA:
undetectable		 4cevD-3smaA:
24.31
4cevE-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 ARG A 278
HIS A 277
MET A 237
ASP A 233
 None
 1.29A 4cevE-3smaA:
undetectable
4cevF-3smaA:
undetectable		 4cevE-3smaA:
24.31
4cevF-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 5 MET A 237
ASP A 233
ARG A 278
HIS A 277
 None
 1.27A 4cevD-3smaA:
0.1
4cevF-3smaA:
0.0		 4cevD-3smaA:
24.31
4cevF-3smaA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 7 LEU A 180
ALA A 258
LEU A 260
SER A 249
 None
 0.64A 4d7bA-3smaA:
undetectable		 4d7bA-3smaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 ARG A  92
THR A  89
TRP A  90
 None
 0.98A 4d7hA-3smaA:
undetectable		 4d7hA-3smaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 ASN A 141
ARG A 209
TYR A 197
TYR A 229
 None
 1.19A 4f8yA-3smaA:
undetectable
4f8yB-3smaA:
undetectable		 4f8yA-3smaA:
17.86
4f8yB-3smaA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3sma FRBF
(Streptomyces
rubellomurinus) 		4 / 6 LEU A 180
ALA A 258
LEU A 260
SER A 249
 None
 0.63A 4ikiB-3smaA:
undetectable		 4ikiB-3smaA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 PHE A 143
ALA A 144
LEU A 169
GLY A 121
MET A 120
 None
None
None
ACO  A 300 (-3.4A)
ACO  A 300 (-4.1A)
 0.99A 4kykA-3smaA:
undetectable
4kykB-3smaA:
undetectable		 4kykA-3smaA:
19.93
4kykB-3smaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		5 / 12 PHE A 143
ALA A 144
MET A  77
LEU A 169
GLY A 119
 None
 1.22A 4kykA-3smaA:
undetectable
4kykB-3smaA:
undetectable		 4kykA-3smaA:
19.93
4kykB-3smaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 CYH A 241
PRO A 246
ASP A 268
 None
 0.95A 4pm5A-3smaA:
undetectable		 4pm5A-3smaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 ARG A  92
THR A  89
TRP A  90
 None
 1.05A 4ug5A-3smaA:
undetectable		 4ug5A-3smaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 ARG A  92
THR A  89
TRP A  90
 None
 1.02A 4uglA-3smaA:
undetectable		 4uglA-3smaA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 3sma FRBF
(Streptomyces
rubellomurinus) 		3 / 3 ARG A  92
THR A  89
TRP A  90
 None
 0.97A 5g6cA-3smaA:
undetectable		 5g6cA-3smaA:
19.13