SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 7 LEU A 259
VAL A 253
GLY A 252
GLY A 249
 None
 0.79A 2wd9A-3sngA:
undetectable		 2wd9A-3sngA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3sng NUCLEASE
(Solanum
lycopersicum) 		5 / 12 HIS A 157
ASP A 151
HIS A 147
ASP A  70
LEU A 190
 SO4  A 601 ( 3.2A)
ZN  A 402 ( 2.4A)
ZN  A 402 (-3.2A)
ZN  A 402 (-2.9A)
None
 1.34A 3lmyA-3sngA:
undetectable		 3lmyA-3sngA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		3 / 3 TYR A  98
ASP A 104
ASP A 110
 BTB  A 603 ( 4.8A)
None
None
 0.69A 3r24A-3sngA:
undetectable		 3r24A-3sngA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 7 HIS A 157
ARG A  73
HIS A 147
HIS A 182
 SO4  A 601 ( 3.2A)
SO4  A 601 (-2.7A)
ZN  A 402 (-3.2A)
None
 1.22A 3zodA-3sngA:
undetectable		 3zodA-3sngA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		3 / 3 ASP A 110
LEU A  84
VAL A 158
 None
NAG  A 501 (-4.3A)
None
 0.69A 4jecB-3sngA:
undetectable		 4jecB-3sngA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3sng NUCLEASE
(Solanum
lycopersicum) 		3 / 3 TYR A 250
GLN A 154
TRP A 248
 None
 1.11A 4kn2C-3sngA:
undetectable		 4kn2C-3sngA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3sng NUCLEASE
(Solanum
lycopersicum) 		5 / 11 MET A  33
GLY A 279
ARG A 281
GLY A 150
LEU A 171
 None
 1.10A 4kt0A-3sngA:
undetectable
4kt0J-3sngA:
undetectable		 4kt0A-3sngA:
18.09
4kt0J-3sngA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 7 VAL A 271
TRP A 184
HIS A 181
GLU A 187
 None
None
ZN  A 403 ( 3.3A)
None
 1.18A 5ad9A-3sngA:
undetectable
5ad9B-3sngA:
undetectable		 5ad9A-3sngA:
20.74
5ad9B-3sngA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3sng NUCLEASE
(Solanum
lycopersicum) 		5 / 12 PRO A  55
LEU A  65
VAL A  72
PHE A 144
LEU A 143
 NAG  A 512 (-3.8A)
NAG  A 512 ( 4.3A)
None
None
None
 1.22A 5cymA-3sngA:
undetectable		 5cymA-3sngA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3sng NUCLEASE
(Solanum
lycopersicum) 		5 / 12 PRO A  55
LEU A  65
VAL A  72
PHE A 144
LEU A 143
 NAG  A 512 (-3.8A)
NAG  A 512 ( 4.3A)
None
None
None
 1.23A 5cyqA-3sngA:
undetectable		 5cyqA-3sngA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 8 ASP A 151
HIS A  85
HIS A 147
ARG A 186
 ZN  A 402 ( 2.4A)
ZN  A 402 ( 3.1A)
ZN  A 402 (-3.2A)
None
 0.81A 5nekB-3sngA:
undetectable		 5nekB-3sngA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 8 ASP A 151
HIS A  85
HIS A 147
HIS A 157
 ZN  A 402 ( 2.4A)
ZN  A 402 ( 3.1A)
ZN  A 402 (-3.2A)
SO4  A 601 ( 3.2A)
 0.99A 5nekB-3sngA:
undetectable		 5nekB-3sngA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 8 ASP A 151
HIS A 147
PRO A  69
ARG A 186
 ZN  A 402 ( 2.4A)
ZN  A 402 (-3.2A)
None
None
 0.82A 5nekB-3sngA:
undetectable		 5nekB-3sngA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 8 ASP A 151
HIS A  85
HIS A 147
ARG A 186
 ZN  A 402 ( 2.4A)
ZN  A 402 ( 3.1A)
ZN  A 402 (-3.2A)
None
 0.89A 5nekD-3sngA:
undetectable		 5nekD-3sngA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 7 GLY A  30
HIS A  31
ASP A  70
ASP A 185
 None
ZN  A 401 (-3.2A)
ZN  A 402 (-2.9A)
ZN  A 403 (-2.1A)
 0.97A 5nnwD-3sngA:
undetectable		 5nnwD-3sngA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3sng NUCLEASE
(Solanum
lycopersicum) 		4 / 7 GLY A  30
HIS A  31
ASP A  70
ASP A 185
 None
ZN  A 401 (-3.2A)
ZN  A 402 (-2.9A)
ZN  A 403 (-2.1A)
 1.04A 5no9D-3sngA:
undetectable		 5no9D-3sngA:
16.46