SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3soa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		6 / 12 LEU A  19
VAL A  27
ALA A  40
GLU A  60
GLY A  94
ALA A 155
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
DB8  A 445 ( 4.2A)
DB8  A 445 ( 4.8A)
None
None
 1.03A 1iepB-3soaA:
19.5		 1iepB-3soaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		3 / 3 PHE A 293
TYR A 179
PRO A 211
 None
 1.18A 1mcnA-3soaA:
undetectable
1mcnB-3soaA:
undetectable
1mcnP-3soaA:
undetectable		 1mcnA-3soaA:
16.44
1mcnB-3soaA:
16.44
1mcnP-3soaA:
0.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		5 / 12 LEU A  57
ARG A   8
SER A  80
ILE A  79
ILE A  44
 None
 1.50A 1ot7B-3soaA:
undetectable		 1ot7B-3soaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		5 / 9 LEU A  19
VAL A  27
LEU A  75
LEU A  87
LEU A  91
 DB8  A 445 (-3.5A)
DB8  A 445 (-4.5A)
None
None
None
 0.73A 1xkkA-3soaA:
19.3		 1xkkA-3soaA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		3 / 3 ARG A 403
ARG A 439
ARG A 423
 None
 1.20A 2jb7A-3soaA:
undetectable
2jb7B-3soaA:
undetectable
2jb7C-3soaA:
undetectable		 2jb7A-3soaA:
17.01
2jb7B-3soaA:
17.01
2jb7C-3soaA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		4 / 5 LEU A 266
GLN A 118
LEU A 120
GLU A 121
 None
 1.03A 3h5gA-3soaA:
undetectable
3h5gB-3soaA:
undetectable		 3h5gA-3soaA:
5.43
3h5gB-3soaA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		3 / 3 GLU A 236
ASP A 238
ASP A 231
 None
 0.66A 3jb2A-3soaA:
undetectable		 3jb2A-3soaA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS8_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3soa CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER
(Homo
sapiens) 		4 / 5 LYS A  56
ARG A  59
ARG A 134
LEU A 159
 None
 1.30A 5os8A-3soaA:
23.3		 5os8A-3soaA:
23.17