SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3soe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HXW_B_RITB301_1 (HIV-1 PROTEASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 9	ASP A 642 GLY A 641 GLY A 681 VAL A 602 ILE A 677	None	1.04A	1hxwA-3soeA: undetectable	1hxwA-3soeA: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_K_BEZK4387_0 (CES1 PROTEIN)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	3 / 3	TRP A 634 LEU A 630 LYS A 700	None	1.35A	1yajK-3soeA: undetectable	1yajK-3soeA: 12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_B_DIFB1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	4 / 7	GLY A 589 ALA A 590 MET A 591 LEU A 594	None	0.74A	2wekB-3soeA: undetectable	2wekB-3soeA: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_A_SAMA601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	0.99A	5wz1A-3soeA: undetectable	5wz1A-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_C_SAMC601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.01A	5wz1C-3soeA: undetectable	5wz1C-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_D_SAMD601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.03A	5wz1D-3soeA: undetectable	5wz1D-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_E_SAME601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.03A	5wz1E-3soeA: undetectable	5wz1E-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_F_SAMF601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.04A	5wz1F-3soeA: undetectable	5wz1F-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_G_SAMG601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.05A	5wz1G-3soeA: undetectable	5wz1G-3soeA: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_H_SAMH601_0 (NS5 METHYLTRANSFERASE)	3soe	MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	5 / 12	GLY A 609 ASP A 642 VAL A 626 ASP A 631 ILE A 629	None	1.03A	5wz1H-3soeA: undetectable	5wz1H-3soeA: 18.94

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HXW_B_RITB301_1","HIV-1 PROTEASE;HIV-1 PROTEASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"ASP A 642;GLY A 641;GLY A 681;VAL A 602;ILE A 677","None","1.04A","1hxwA-3soeA:undetectable","1hxwA-3soeA:22.31"],["1YAJ_K_BEZK4387_0","CES1 PROTEIN","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",3,"TRP A 634;LEU A 630;LYS A 700","None","1.35A","1yajK-3soeA:undetectable","1yajK-3soeA:12.48"],["2WEK_B_DIFB1376_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",4,"GLY A 589;ALA A 590;MET A 591;LEU A 594","None","0.74A","2wekB-3soeA:undetectable","2wekB-3soeA:16.27"],["5WZ1_A_SAMA601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","0.99A","5wz1A-3soeA:undetectable","5wz1A-3soeA:18.94"],["5WZ1_C_SAMC601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.01A","5wz1C-3soeA:undetectable","5wz1C-3soeA:18.94"],["5WZ1_D_SAMD601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.03A","5wz1D-3soeA:undetectable","5wz1D-3soeA:18.94"],["5WZ1_E_SAME601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.03A","5wz1E-3soeA:undetectable","5wz1E-3soeA:18.94"],["5WZ1_F_SAMF601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.04A","5wz1F-3soeA:undetectable","5wz1F-3soeA:18.94"],["5WZ1_G_SAMG601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.05A","5wz1G-3soeA:undetectable","5wz1G-3soeA:18.94"],["5WZ1_H_SAMH601_0","NS5 METHYLTRANSFERASE","3soe","MEMBRANE-ASSOCIATED GUANYLATE KINASE, WW AND PDZ DOMAIN-CONTAINING PROTEIN 3","Homo sapiens",5,"GLY A 609;ASP A 642;VAL A 626;ASP A 631;ILE A 629","None","1.03A","5wz1H-3soeA:undetectable","5wz1H-3soeA:18.94"]]