SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3som'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 162
ALA A 103
ALA A 120
ILE A 160
GLN A 118
 None
None
None
B12  A 301 (-4.2A)
B12  A 301 (-3.2A)
 1.08A 1nt2A-3somA:
undetectable		 1nt2A-3somA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		4 / 8 PRO A  56
PHE A 154
TRP A 157
TYR A 205
 None
 1.49A 4v30B-3somA:
undetectable		 4v30B-3somA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		4 / 8 PRO A  56
PHE A 223
PHE A 154
TYR A 205
 None
FLC  A 501 (-3.9A)
None
None
 1.17A 5amkA-3somA:
undetectable		 5amkA-3somA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		4 / 8 PRO A  56
PHE A 154
TRP A 157
TYR A 205
 None
 1.47A 5oh1C-3somA:
undetectable		 5oh1C-3somA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		3 / 3 ASP A  77
PHE A 223
ARG A 161
 None
FLC  A 501 (-3.9A)
FLC  A 501 (-2.6A)
 0.82A 5yw0A-3somA:
undetectable		 5yw0A-3somA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3som METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN
(Homo
sapiens) 		3 / 3 ALA A  57
PHE A 154
GLN A 212
 None
 0.81A 6eceA-3somA:
undetectable		 6eceA-3somA:
23.31