SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.32A 1fohA-3sopA:
undetectable		 1fohA-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.31A 1fohB-3sopA:
undetectable		 1fohB-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.32A 1fohC-3sopA:
undetectable		 1fohC-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.32A 1fohD-3sopA:
undetectable		 1fohD-3sopA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.30A 1pn0A-3sopA:
undetectable		 1pn0A-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.31A 1pn0B-3sopA:
undetectable		 1pn0B-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.33A 1pn0C-3sopA:
undetectable		 1pn0C-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 GLY A  68
MET A  65
VAL A  67
ILE A 142
GLY A 128
 None
 1.33A 1pn0D-3sopA:
undetectable		 1pn0D-3sopA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		3 / 3 HIS A 183
ASP A 189
ASN A 135
 None
 0.80A 1wg8B-3sopA:
2.3		 1wg8B-3sopA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 9 LEU A 228
ILE A 233
GLY A 232
LEU A 185
SER A 184
 None
 1.12A 3ai9X-3sopA:
undetectable		 3ai9X-3sopA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 11 VAL A 205
VAL A 224
TYR A 176
PHE A 177
LEU A  72
 None
 1.47A 3m8pA-3sopA:
undetectable
3m8pB-3sopA:
undetectable		 3m8pA-3sopA:
19.50
3m8pB-3sopA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_B_QMRB1214_1
(CAPITELLA TELETA
ACHBP)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 9 ILE A 124
ILE A 142
PHE A 192
TYR A 176
CYH A 174
 None
 1.47A 4afgA-3sopA:
undetectable
4afgE-3sopA:
undetectable		 4afgA-3sopA:
22.42
4afgE-3sopA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		4 / 7 LEU A  77
SER A  84
VAL A 123
PHE A  62
 None
 0.99A 4wnvD-3sopA:
undetectable		 4wnvD-3sopA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		4 / 8 LEU A 309
LEU A 312
ILE A  64
MET A 119
 None
 0.99A 4xtaB-3sopA:
undetectable		 4xtaB-3sopA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 10 LEU A 228
ILE A 233
GLY A 232
LEU A 185
SER A 184
 None
 1.08A 5twjB-3sopA:
undetectable		 5twjB-3sopA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 12 LEU A 228
ILE A 233
GLY A 232
LEU A 185
SER A 184
 None
 1.05A 5twjC-3sopA:
undetectable		 5twjC-3sopA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 12 LEU A 300
PHE A 177
ILE A 203
ILE A 146
HIS A 320
 None
 1.13A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sop NEURONAL-SPECIFIC
SEPTIN-3
(Homo
sapiens) 		5 / 12 LEU A 300
PHE A 177
ILE A 203
ILE A 146
TYR A 150
 None
 1.20A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable