SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 253
ARG A 116
PHE A 189
PHE A 262
 None
 1.49A 1e73M-3sq7A:
undetectable		 1e73M-3sq7A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 265
LEU A 268
LEU A 460
TYR A 487
ILE A 197
 None
 1.09A 1s9pA-3sq7A:
undetectable		 1s9pA-3sq7A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 317
PHE A 411
MET A 406
SER A 402
 None
 1.26A 1wrlC-3sq7A:
undetectable		 1wrlC-3sq7A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 THR A 423
VAL A 422
THR A 382
SER A 389
GLN A 213
 SO4  A   6 (-3.9A)
None
None
None
None
 1.28A 2ij7A-3sq7A:
0.0		 2ij7A-3sq7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_D_TPFD2473_1
(CYTOCHROME P450 121)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 423
VAL A 422
THR A 382
SER A 389
GLN A 213
 SO4  A   6 (-3.9A)
None
None
None
None
 1.20A 2ij7D-3sq7A:
undetectable		 2ij7D-3sq7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 THR A 423
VAL A 422
THR A 382
SER A 389
GLN A 213
 SO4  A   6 (-3.9A)
None
None
None
None
 1.26A 2ij7F-3sq7A:
0.0		 2ij7F-3sq7A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 369
TYR A 415
PRO A 370
 None
 1.49A 2j9cC-3sq7A:
undetectable		 2j9cC-3sq7A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 256
VAL A 257
ILE A 197
SER A 219
PHE A 262
 None
 1.44A 2vdyB-3sq7A:
undetectable		 2vdyB-3sq7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 466
GLN A 309
THR A 310
THR A 327
 None
 1.48A 2zj0D-3sq7A:
undetectable		 2zj0D-3sq7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 103
PHE A  82
ALA A 431
SER A 201
TYR A 461
 None
 1.44A 3apwA-3sq7A:
undetectable		 3apwA-3sq7A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 103
PHE A  82
ALA A 431
SER A 201
TYR A 461
 None
 1.36A 3apwB-3sq7A:
undetectable		 3apwB-3sq7A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 293
LEU A 199
VAL A 271
LEU A 222
 None
 0.77A 3g8iA-3sq7A:
undetectable		 3g8iA-3sq7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 10 TYR A 124
LEU A 129
LYS A 167
VAL A 168
ILE A 253
 None
 1.39A 3kz7A-3sq7A:
undetectable		 3kz7A-3sq7A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3sq7 TYROSYL-DNA
PHOSPHODIESTERASE 1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 483
LEU A 185
LEU A 237
TYR A 244
HIS A 181
 None
 1.22A 5eb5A-3sq7A:
undetectable		 5eb5A-3sq7A:
22.18