SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sqg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 11 PRO C  21
ASN B 313
VAL C 112
TYR C 109
GLY C 111
 None
None
None
GOL  C 281 (-4.6A)
None
 1.24A 1fkpA-3sqgC:
undetectable		 1fkpA-3sqgC:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 7 ILE B 118
GLU B 220
LEU B 187
GLY B 125
 None
 0.88A 1mt1H-3sqgB:
undetectable
1mt1K-3sqgB:
undetectable		 1mt1H-3sqgB:
13.79
1mt1K-3sqgB:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 8 LEU B 187
GLY B 125
ILE B 118
GLU B 220
 None
 0.91A 1n13A-3sqgB:
undetectable
1n13F-3sqgB:
undetectable		 1n13A-3sqgB:
9.07
1n13F-3sqgB:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ASP A 330
GLY A 502
ALA A 425
PHE A 334
ASN A 500
 None
None
None
0AF  A 333 (-3.5A)
GL3  A 464 (-3.1A)
 1.25A 1nw3A-3sqgA:
undetectable		 1nw3A-3sqgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 GLY A 502
VAL A 492
ALA A 425
PHE A 334
ASN A 500
 None
0AF  A 333 ( 4.5A)
None
0AF  A 333 (-3.5A)
GL3  A 464 (-3.1A)
 1.21A 1nw3A-3sqgA:
undetectable		 1nw3A-3sqgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 11 VAL C 224
ASN C 219
GLU A 405
TYR C 217
ASP C 229
 None
 1.27A 1t6zB-3sqgC:
undetectable		 1t6zB-3sqgC:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 11 VAL C 224
ASN C 219
TYR C 217
LEU C 272
ASP C 229
 None
 1.23A 1t6zB-3sqgC:
undetectable		 1t6zB-3sqgC:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 7 GLN B 205
ALA C  65
ARG B 200
GLU B 423
 None
 1.31A 1t9wA-3sqgB:
1.4		 1t9wA-3sqgB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		3 / 3 TYR A 507
ARG C 244
GLN A 470
 None
 0.98A 1tw4A-3sqgA:
undetectable		 1tw4A-3sqgA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 11 LEU B  47
ILE B  75
VAL B 155
GLY B 154
LEU B 133
 None
 1.31A 2bxeA-3sqgB:
undetectable		 2bxeA-3sqgB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 7 SER B 356
SER B 355
SER B 359
GLN B 321
 None
 1.03A 2cmlA-3sqgB:
undetectable		 2cmlA-3sqgB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 8 SER B 356
SER B 355
SER B 359
GLN B 321
 None
 1.02A 2cmlB-3sqgB:
undetectable		 2cmlB-3sqgB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 8 SER B 356
SER B 355
SER B 359
GLN B 321
 None
 1.11A 2cmlD-3sqgB:
undetectable		 2cmlD-3sqgB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 GLY B 346
GLY B 383
GLU B 214
ALA B 351
HIS B 380
 None
None
None
None
MHO  A 499 ( 4.6A)
 0.96A 2fk8A-3sqgB:
undetectable		 2fk8A-3sqgB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 12 VAL C 138
ILE C 122
ILE C 123
HIS C  42
LEU C  40
 None
 1.29A 2ft9A-3sqgC:
undetectable		 2ft9A-3sqgC:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		3 / 3 VAL C  37
GLU C  33
GLU C  34
 None
 0.79A 2nv4A-3sqgC:
undetectable		 2nv4A-3sqgC:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 ALA A 325
ALA A 426
ALA A 425
GLN A 504
 None
 0.88A 2nyrB-3sqgA:
undetectable		 2nyrB-3sqgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 ALA A 326
ALA A 426
ALA A 425
GLN A 504
 None
 0.91A 2nyrB-3sqgA:
undetectable		 2nyrB-3sqgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 7 LEU B 133
ILE B 137
PHE B  54
GLU B  51
 None
 0.97A 2opxA-3sqgB:
undetectable		 2opxA-3sqgB:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		3 / 3 VAL B  76
ASP B  77
GLU B  51
 None
 0.70A 2qeuA-3sqgB:
1.0		 2qeuA-3sqgB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		3 / 3 VAL B  76
ASP B  77
GLU B  51
 None
 0.72A 2qeuC-3sqgB:
0.7		 2qeuC-3sqgB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		4 / 7 SER C 118
HIS C 156
HIS C 158
ARG A 420
 None
 1.37A 2vmyA-3sqgC:
undetectable
2vmyB-3sqgC:
undetectable		 2vmyA-3sqgC:
23.28
2vmyB-3sqgC:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 6 THR B 338
GLU B 335
MET B 295
PHE B 345
 None
 1.22A 2w98B-3sqgB:
undetectable		 2w98B-3sqgB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 10 THR A 351
SER A 449
TRP A 446
GLY A 502
ALA A 506
 None
 1.41A 2x2iB-3sqgA:
undetectable		 2x2iB-3sqgA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 11 THR A 304
TYR A 329
ALA A 508
GLY A 509
ALA A 512
 None
 1.27A 2xh9A-3sqgA:
undetectable		 2xh9A-3sqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 10 THR A 304
TYR A 329
ALA A 508
GLY A 509
ALA A 512
 None
 1.23A 2xh9B-3sqgA:
undetectable		 2xh9B-3sqgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 VAL A 275
PHE A 532
VAL A 523
TRP A 522
 None
 1.30A 2y00A-3sqgA:
0.3		 2y00A-3sqgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		5 / 12 ALA B 319
PRO B 368
PHE A 463
GLY B 325
VAL B 310
 None
 1.19A 2zifA-3sqgB:
undetectable		 2zifA-3sqgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		5 / 12 ALA B 319
PRO B 368
PHE A 463
GLY B 325
VAL B 310
 None
 1.18A 2zifB-3sqgB:
undetectable		 2zifB-3sqgB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 GLU A  45
ARG A  42
ASN A  98
ASP A  93
 None
 1.28A 2zq9A-3sqgA:
0.0		 2zq9A-3sqgA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 PRO A 307
ILE A 315
LEU A 319
ILE A 322
LEU A 510
 None
 1.10A 3a50E-3sqgA:
undetectable		 3a50E-3sqgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 5 GLU C  61
VAL C  66
CYH C  64
ARG B 318
 None
 1.10A 3amuA-3sqgC:
1.0		 3amuA-3sqgC:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA A 512
GLY A 298
LEU A 510
SER A 321
LEU A 319
 None
 1.30A 3bxoA-3sqgA:
undetectable		 3bxoA-3sqgA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 TYR A 497
ALA A 325
TYR A 337
MET A 281
 None
None
0AF  A 333 ( 4.1A)
0AF  A 333 ( 4.8A)
 1.07A 3d91A-3sqgA:
undetectable		 3d91A-3sqgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 LEU A 369
GLY A 368
ALA A 433
THR A 436
LEU A 384
 None
 1.02A 3dh0B-3sqgA:
undetectable		 3dh0B-3sqgA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 8 PRO C  98
ALA C 102
ALA C 105
PRO C 114
HIS C 158
 None
 1.12A 3dtuC-3sqgC:
undetectable
3dtuD-3sqgC:
undetectable		 3dtuC-3sqgC:
19.37
3dtuD-3sqgC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 6 GLY A 475
TYR A 497
GLY A 484
MET A 485
 None
 1.09A 3e9rA-3sqgA:
undetectable		 3e9rA-3sqgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 6 GLY A 475
TYR A 497
GLY A 484
MET A 485
 None
 1.11A 3e9rC-3sqgA:
undetectable		 3e9rC-3sqgA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		3 / 3 ASN A 145
HIS A 146
VAL A 153
 None
None
M43  A1001 (-3.5A)
 0.84A 3elzB-3sqgA:
undetectable		 3elzB-3sqgA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 VAL A 419
CYH A 423
ALA A 425
ALA A 426
LEU A 510
 None
 0.78A 3fc6C-3sqgA:
undetectable		 3fc6C-3sqgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 11 ARG C 147
TYR C  87
GLN C  86
VAL C  85
ILE C  96
 None
 1.29A 3ganA-3sqgC:
undetectable		 3ganA-3sqgC:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		3 / 3 CYH B 331
PRO B 341
ASP B 344
 None
 0.75A 3hlwB-3sqgB:
undetectable		 3hlwB-3sqgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 5 ASN B 180
THR B 127
SER B 123
SER B 120
 None
 1.44A 3hlwB-3sqgB:
undetectable		 3hlwB-3sqgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 LEU A 384
GLY A 373
ILE A 367
LEU A 389
ILE A 393
 None
 1.05A 3ijdB-3sqgA:
undetectable		 3ijdB-3sqgA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 4 ARG C 101
ASP C 207
GLY C 166
THR C 145
 None
 1.50A 3k4vB-3sqgC:
undetectable		 3k4vB-3sqgC:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 GLY A 461
GLY A 502
ALA A 425
ALA A 426
CYH A 361
 None
 1.00A 3keeA-3sqgA:
undetectable		 3keeA-3sqgA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		4 / 7 GLU C 227
LEU A 448
THR C 237
ALA C 238
 None
 1.27A 3mbgA-3sqgC:
undetectable
3mbgB-3sqgC:
undetectable		 3mbgA-3sqgC:
17.67
3mbgB-3sqgC:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		3 / 3 ASP A 359
GLU A 366
SER A  15
 None
 0.67A 3p2kA-3sqgA:
undetectable		 3p2kA-3sqgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA A 552
GLY A 549
ALA A 348
ASN A  99
HIS A  95
 None
 1.10A 3qxyA-3sqgA:
undetectable		 3qxyA-3sqgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 8 ILE C 133
GLU C 137
TYR C  87
LEU C 150
 None
 1.05A 3rqwI-3sqgC:
undetectable
3rqwJ-3sqgC:
undetectable		 3rqwI-3sqgC:
17.66
3rqwJ-3sqgC:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.96A 3rukB-3sqgB:
undetectable		 3rukB-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 7 ASP C  89
GLY C 157
SER C  94
THR C  97
 None
 1.05A 4ac9C-3sqgC:
undetectable		 4ac9C-3sqgC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 8 TYR C 143
TYR C  87
ILE C 130
ILE C  36
 None
 0.76A 4afgD-3sqgC:
undetectable
4afgE-3sqgC:
undetectable		 4afgD-3sqgC:
20.48
4afgE-3sqgC:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		5 / 12 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
 None
 0.92A 4fp9A-3sqgC:
undetectable		 4fp9A-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		5 / 12 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
 None
 0.92A 4fp9C-3sqgC:
undetectable		 4fp9C-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon;
uncultured
archaeon) 		5 / 12 PRO C 251
GLY C 247
GLY C 248
LEU B 297
ASP B 344
 None
 0.92A 4fp9F-3sqgC:
undetectable		 4fp9F-3sqgC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		3 / 3 GLU A 547
ASP A 540
ASP A 108
 None
 0.76A 4gc9A-3sqgA:
undetectable		 4gc9A-3sqgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		5 / 12 PHE C  93
GLN C 226
ARG C  15
VAL C  11
LEU C 211
 None
 1.43A 4k39A-3sqgC:
undetectable		 4k39A-3sqgC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		3 / 3 SER C 233
TYR C 217
PRO B 284
 None
 0.97A 4lbgA-3sqgC:
undetectable		 4lbgA-3sqgC:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.93A 4nkvA-3sqgB:
undetectable		 4nkvA-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.93A 4nkvB-3sqgB:
undetectable		 4nkvB-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.94A 4nkvC-3sqgB:
undetectable		 4nkvC-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.93A 4nkvD-3sqgB:
undetectable		 4nkvD-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA B 267
ASN B 326
ILE B 327
GLY B 309
ALA B 308
 None
 0.89A 4nkxA-3sqgB:
undetectable		 4nkxA-3sqgB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		3 / 3 ASP C 129
ARG C  81
THR C  73
 GOL  C 281 ( 4.6A)
None
None
 0.88A 4p3rA-3sqgC:
undetectable		 4p3rA-3sqgC:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		3 / 3 CYH B 331
PRO B 341
ASP B 344
 None
 0.80A 4pm5A-3sqgB:
undetectable		 4pm5A-3sqgB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 SER B 352
GLY B 325
GLN B 329
GLY B 309
GLU B 239
 None
 0.80A 4r29D-3sqgB:
undetectable		 4r29D-3sqgB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.33A 4w5oA-3sqgA:
undetectable		 4w5oA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.30A 4w5rA-3sqgA:
undetectable		 4w5rA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.30A 4w5tA-3sqgA:
0.5		 4w5tA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 11 LEU A 451
GLY B 350
LEU A 467
GLN A 470
ALA A 473
 None
None
GL3  A 464 ( 4.6A)
None
None
 1.31A 4wnuC-3sqgA:
undetectable		 4wnuC-3sqgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 LEU A 115
GLY A 122
LEU A 124
VAL A 132
VAL A 245
 None
 1.06A 4wnwB-3sqgA:
0.0		 4wnwB-3sqgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 6 LEU B  47
LEU B  50
GLU B  51
ILE B 137
 None
 0.72A 4ww7A-3sqgB:
undetectable		 4ww7A-3sqgB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.32A 4z4cA-3sqgA:
undetectable		 4z4cA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.32A 4z4dA-3sqgA:
undetectable		 4z4dA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 5 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.30A 4z4eA-3sqgA:
undetectable		 4z4eA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.36A 4z4gA-3sqgA:
undetectable		 4z4gA-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 5 TYR B 363
GLY A 343
TYR A 347
GLY A 502
 TP7  A1002 (-4.1A)
None
None
None
 1.05A 5ayfA-3sqgB:
undetectable		 5ayfA-3sqgB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 7 TYR A 507
TYR A 494
GLY A 475
LEU A 443
 None
 1.21A 5bphB-3sqgA:
undetectable		 5bphB-3sqgA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		4 / 5 GLU B 423
ASP B  10
VAL B 199
ALA B 422
 None
 1.44A 5dl9A-3sqgB:
undetectable		 5dl9A-3sqgB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		3 / 3 GLU A 488
TRP A 522
ASN A 518
 None
 1.00A 5dv4A-3sqgA:
undetectable		 5dv4A-3sqgA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 11 ALA B 136
ALA B 132
LEU B 133
LEU B  47
VAL B 111
 None
 1.15A 5eb5A-3sqgB:
undetectable		 5eb5A-3sqgB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		3 / 3 MET A 450
HIS A 503
GLY A 461
 None
 0.80A 5gwzB-3sqgA:
undetectable		 5gwzB-3sqgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		4 / 8 TYR C 109
LEU C  25
LEU C 142
THR C 148
 GOL  C 281 (-4.6A)
None
None
None
 1.05A 5hs6A-3sqgC:
undetectable		 5hs6A-3sqgC:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3sqg METHYL-COENZYME M
REDUCTASE, GAMMA
SUBUNIT
(uncultured
archaeon) 		3 / 3 GLY C 266
ASP C 235
ASN C   8
 None
 0.57A 5jglA-3sqgC:
undetectable		 5jglA-3sqgC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA A 257
VAL A 153
GLY A 151
ALA A 147
LEU A 148
 M43  A1001 (-3.4A)
M43  A1001 (-3.5A)
None
None
None
 1.06A 5jw1A-3sqgA:
undetectable		 5jw1A-3sqgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ALA A 257
VAL A 153
GLY A 151
ALA A 147
LEU A 148
 M43  A1001 (-3.4A)
M43  A1001 (-3.5A)
None
None
None
 1.02A 5jw1B-3sqgA:
undetectable		 5jw1B-3sqgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		4 / 4 PHE A  10
VAL A 410
ALA A  13
PHE A  18
 None
 1.37A 5ki6A-3sqgA:
undetectable		 5ki6A-3sqgA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		5 / 12 ILE B 137
ILE B  75
LEU B  50
SER B 144
VAL B 143
 None
 1.26A 5km9B-3sqgB:
undetectable		 5km9B-3sqgB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT
(uncultured
archaeon) 		3 / 3 TYR B 301
ALA B 243
TYR B 238
 None
 0.80A 5uunB-3sqgB:
undetectable		 5uunB-3sqgB:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT
(uncultured
archaeon) 		5 / 9 ILE A 315
LEU A 369
GLY A 368
MET A 376
ALA A 377
 None
 1.43A 5x66C-3sqgA:
undetectable		 5x66C-3sqgA:
18.52