SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 225
PHE A 338
TYR A 205
VAL A 337
 None
 1.32A 1ibgH-3sqiA:
undetectable		 1ibgH-3sqiA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 ASN A 272
TRP A 275
GLN A 273
 None
 1.44A 1xoqA-3sqiA:
undetectable		 1xoqA-3sqiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 PRO A 198
THR A 196
PRO A 194
 None
 0.85A 2d55C-3sqiA:
undetectable		 2d55C-3sqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.07A 2dysA-3sqiA:
undetectable
2dysJ-3sqiA:
undetectable		 2dysA-3sqiA:
19.72
2dysJ-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.03A 2dysN-3sqiA:
undetectable
2dysW-3sqiA:
undetectable		 2dysN-3sqiA:
19.72
2dysW-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 8 VAL A 159
THR A 158
ASP A 142
ILE A 234
 None
 0.89A 2qbmA-3sqiA:
undetectable		 2qbmA-3sqiA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 PRO A 198
ASN A 148
ARG A 312
 None
 1.00A 2qeuB-3sqiA:
2.2		 2qeuB-3sqiA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.07A 2zxwA-3sqiA:
undetectable
2zxwJ-3sqiA:
undetectable		 2zxwA-3sqiA:
19.72
2zxwJ-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.06A 3abmA-3sqiA:
undetectable
3abmJ-3sqiA:
undetectable		 3abmA-3sqiA:
19.72
3abmJ-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.07A 3asoA-3sqiA:
undetectable
3asoJ-3sqiA:
undetectable		 3asoA-3sqiA:
19.72
3asoJ-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		5 / 12 LEU A 208
LEU A 137
LEU A 140
GLN A 144
LEU A 345
 None
 1.44A 3d90A-3sqiA:
undetectable		 3d90A-3sqiA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		5 / 12 LEU A 341
SER A 343
ILE A 199
LEU A 177
ASP A 170
 None
 1.20A 3ko0A-3sqiA:
undetectable
3ko0B-3sqiA:
undetectable
3ko0C-3sqiA:
undetectable
3ko0D-3sqiA:
undetectable		 3ko0A-3sqiA:
12.24
3ko0B-3sqiA:
12.24
3ko0C-3sqiA:
12.24
3ko0D-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		5 / 11 ASP A 170
LEU A 177
LEU A 341
SER A 343
ILE A 199
 None
 1.18A 3ko0A-3sqiA:
undetectable
3ko0B-3sqiA:
undetectable
3ko0I-3sqiA:
0.0
3ko0J-3sqiA:
undetectable		 3ko0A-3sqiA:
12.24
3ko0B-3sqiA:
12.24
3ko0I-3sqiA:
12.24
3ko0J-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 340
ILE A 199
CYH A 197
PHE A 195
 None
 0.99A 3ko0S-3sqiA:
undetectable		 3ko0S-3sqiA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		5 / 10 LEU A  88
LYS A  48
VAL A  51
ILE A  54
ILE A  22
 None
 1.39A 3kz7A-3sqiA:
undetectable		 3kz7A-3sqiA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 LEU A 164
TYR A 206
MET A 202
THR A 201
 None
 1.07A 3wg7A-3sqiA:
undetectable
3wg7J-3sqiA:
undetectable		 3wg7A-3sqiA:
19.72
3wg7J-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 TYR A  53
ASP A  59
ASP A  63
 None
 0.86A 4a6eA-3sqiA:
undetectable		 4a6eA-3sqiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 PHE A 191
THR A 299
LEU A 340
 None
 0.73A 4qztA-3sqiA:
undetectable		 4qztA-3sqiA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		4 / 6 ILE A 361
LEU A 367
PHE A 362
THR A 347
 None
 1.05A 5b1aN-3sqiA:
undetectable
5b1aW-3sqiA:
undetectable		 5b1aN-3sqiA:
19.72
5b1aW-3sqiA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		3 / 3 VAL A  96
GLN A  89
CYH A  68
 None
 0.86A 5icxC-3sqiA:
undetectable
5icxF-3sqiA:
undetectable		 5icxC-3sqiA:
17.66
5icxF-3sqiA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3sqi KLLA0E03807P
(Kluyveromyces
lactis) 		6 / 12 GLY A 176
LEU A 164
VAL A 344
THR A 347
VAL A 337
ALA A 336
 None
 1.45A 5kpcA-3sqiA:
undetectable		 5kpcA-3sqiA:
22.10