SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sql'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 GLY A  92
ALA A 145
THR A 131
ILE A  89
None
0.79A 1gtnP-3sqlA:
undetectable
1gtnQ-3sqlA:
undetectable
1gtnP-3sqlA:
9.02
1gtnQ-3sqlA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 ASP A 303
LEU A 273
GLY A 272
ARG A 265
None
None
SO4  A 543 ( 3.8A)
None
0.77A 1mt1G-3sqlA:
undetectable
1mt1J-3sqlA:
undetectable
1mt1G-3sqlA:
7.61
1mt1J-3sqlA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 ARG A 265
ASP A 303
LEU A 273
GLY A 272
None
None
None
SO4  A 543 ( 3.8A)
0.80A 1mt1H-3sqlA:
undetectable
1mt1K-3sqlA:
undetectable
1mt1H-3sqlA:
12.52
1mt1K-3sqlA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 ARG A 265
ASP A 303
LEU A 273
GLY A 272
None
None
None
SO4  A 543 ( 3.8A)
0.82A 1n13D-3sqlA:
undetectable
1n13E-3sqlA:
undetectable
1n13D-3sqlA:
12.52
1n13E-3sqlA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 ASP A 303
LEU A 273
GLY A 272
ARG A 265
None
None
SO4  A 543 ( 3.8A)
None
0.80A 1n13A-3sqlA:
undetectable
1n13F-3sqlA:
undetectable
1n13A-3sqlA:
7.61
1n13F-3sqlA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 ARG A 265
ASP A 303
LEU A 273
GLY A 272
None
None
None
SO4  A 543 ( 3.8A)
0.81A 1n13H-3sqlA:
undetectable
1n13K-3sqlA:
undetectable
1n13H-3sqlA:
12.52
1n13K-3sqlA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 ASP A 303
LEU A 273
GLY A 272
ARG A 265
None
None
SO4  A 543 ( 3.8A)
None
0.80A 1n13G-3sqlA:
undetectable
1n13J-3sqlA:
undetectable
1n13G-3sqlA:
7.61
1n13J-3sqlA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 LYS A 367
ALA A 370
GLU A 512
GLU A 374
None
1.13A 1qhyA-3sqlA:
2.5
1qhyA-3sqlA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 THR A 131
THR A 130
SER A 359
MET A 506
None
1.23A 1tv8A-3sqlA:
2.6
1tv8A-3sqlA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 10 ARG A  25
LEU A  60
ILE A 140
ARG A  96
GLY A  92
None
1.50A 2bxqA-3sqlA:
0.5
2bxqA-3sqlA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 ILE A 244
ARG A 217
LEU A 218
GLU A 222
None
0.93A 2cdqA-3sqlA:
undetectable
2cdqA-3sqlA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 THR A 131
THR A 130
SER A 359
MET A 506
None
1.16A 2fb2A-3sqlA:
3.6
2fb2A-3sqlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 4 GLN A 380
GLU A 496
ILE A 497
PRO A 498
None
1.42A 2fcnA-3sqlA:
undetectable
2fcnA-3sqlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 ARG A 217
PRO A 106
VAL A 171
MET A 107
None
None
None
SO4  A 542 (-3.7A)
1.44A 2qd4A-3sqlA:
3.8
2qd4A-3sqlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 ARG A 265
ASP A 303
LEU A 273
GLY A 272
None
None
None
SO4  A 543 ( 3.8A)
0.78A 2qqcH-3sqlA:
undetectable
2qqcK-3sqlA:
undetectable
2qqcH-3sqlA:
12.90
2qqcK-3sqlA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 PHE A 501
PRO A 104
ALA A 108
LEU A 373
None
1.04A 2vcvA-3sqlA:
undetectable
2vcvA-3sqlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 ILE A 315
GLY A  56
GLY A  54
GLN A  16
EDO  A 545 (-3.8A)
None
None
None
0.77A 2wd9B-3sqlA:
undetectable
2wd9B-3sqlA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 GLY A  57
ILE A  81
GLN A  76
LEU A  84
None
0.91A 2xrhA-3sqlA:
undetectable
2xrhA-3sqlA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 LEU A 517
ILE A 386
PRO A 498
VAL A 403
None
0.95A 2ygoA-3sqlA:
undetectable
2ygoA-3sqlA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 5 ILE A 161
SER A 483
PRO A 484
PHE A 486
None
None
SO4  A 547 (-4.5A)
None
1.35A 3bjwC-3sqlA:
undetectable
3bjwC-3sqlA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 12 SER A 204
GLY A 198
GLY A 196
ASN A 156
VAL A 158
ACY  A 541 ( 3.8A)
None
None
None
None
1.30A 3f8wB-3sqlA:
undetectable
3f8wB-3sqlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 GLY A 504
GLY A 482
THR A 377
ALA A 509
None
0.85A 3fpjB-3sqlA:
2.0
3fpjB-3sqlA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 VAL A 275
ILE A  59
ILE A 304
LEU A 305
None
0.76A 3hegA-3sqlA:
undetectable
3hegA-3sqlA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 12 TYR A 481
ILE A 386
ALA A 415
ILE A 479
PRO A 443
None
1.09A 3jayA-3sqlA:
undetectable
3jayA-3sqlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
3 / 3 ASP A  43
ARG A  35
ARG A  49
None
None
EDO  A 545 (-4.6A)
1.03A 3k37A-3sqlA:
undetectable
3k37A-3sqlA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 12 LEU A 255
GLY A 301
ALA A 302
ASP A 303
ILE A 304
None
1.05A 3ogqB-3sqlA:
undetectable
3ogqB-3sqlA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 11 THR A 202
THR A 200
ASN A 156
GLY A 198
ASP A 149
None
1.42A 3sfuC-3sqlA:
undetectable
3sfuC-3sqlA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 6 LEU A 242
ILE A 211
ASN A 156
VAL A 158
None
0.92A 4a9kA-3sqlA:
undetectable
4a9kA-3sqlA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 12 ASP A 310
GLN A 296
VAL A 295
ILE A 318
ILE A  22
None
1.35A 4drhA-3sqlA:
undetectable
4drhA-3sqlA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 12 MET A 307
LEU A 273
LEU A 144
ILE A 339
GLN A  20
ACY  A 548 ( 4.7A)
None
ACY  A 548 ( 4.6A)
None
None
1.21A 4f4dA-3sqlA:
undetectable
4f4dA-3sqlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 ARG A 217
VAL A 237
VAL A 150
GLY A 198
None
0.99A 4mk4A-3sqlA:
3.6
4mk4A-3sqlA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 5 ILE A 418
CYH A 514
LEU A 445
HIS A 422
None
1.21A 5hrqC-3sqlA:
undetectable
5hrqD-3sqlA:
undetectable
5hrqL-3sqlA:
undetectable
5hrqC-3sqlA:
3.46
5hrqD-3sqlA:
4.76
5hrqL-3sqlA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
6 / 12 GLY A 283
THR A 285
THR A 292
ALA A 253
LEU A 255
ALA A 297
None
1.47A 5kpcA-3sqlA:
undetectable
5kpcA-3sqlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 9 ALA A 191
THR A 190
ALA A 145
GLY A 233
ALA A 229
None
None
None
SO4  A 543 (-4.6A)
None
1.12A 5l5zK-3sqlA:
undetectable
5l5zL-3sqlA:
undetectable
5l5zK-3sqlA:
16.82
5l5zL-3sqlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 9 ALA A 191
THR A 190
ALA A 145
GLY A 233
ALA A 229
None
None
None
SO4  A 543 (-4.6A)
None
1.12A 5l5zY-3sqlA:
undetectable
5l5zZ-3sqlA:
undetectable
5l5zY-3sqlA:
16.82
5l5zZ-3sqlA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 11 ALA A 191
THR A 190
ALA A 145
GLY A 233
ALA A 229
None
None
None
SO4  A 543 (-4.6A)
None
1.04A 5lf3K-3sqlA:
undetectable
5lf3L-3sqlA:
undetectable
5lf3K-3sqlA:
15.88
5lf3L-3sqlA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 11 ALA A 191
THR A 190
ALA A 145
GLY A 233
ALA A 229
None
None
None
SO4  A 543 (-4.6A)
None
1.04A 5lf3Y-3sqlA:
undetectable
5lf3Z-3sqlA:
undetectable
5lf3Y-3sqlA:
15.88
5lf3Z-3sqlA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 PHE A 103
VAL A 372
ILE A 121
THR A 368
None
0.80A 5vkqA-3sqlA:
undetectable
5vkqD-3sqlA:
1.1
5vkqA-3sqlA:
16.23
5vkqD-3sqlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 9 ALA A 108
PHE A 178
GLY A 175
PHE A 164
GLY A 110
None
None
None
None
SO4  A 542 (-3.8A)
1.29A 6awoA-3sqlA:
undetectable
6awoA-3sqlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 9 ALA A 108
PHE A 178
GLY A 175
PHE A 164
GLY A 110
None
None
None
None
SO4  A 542 (-3.8A)
1.29A 6awqA-3sqlA:
undetectable
6awqA-3sqlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 8 LEU A 188
VAL A 275
LEU A 273
ILE A 304
None
0.85A 6cb4A-3sqlA:
undetectable
6cb4A-3sqlA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 ALA A 321
THR A 320
VAL A 295
PRO A 308
None
0.92A 6cduA-3sqlA:
undetectable
6cduE-3sqlA:
undetectable
6cduA-3sqlA:
22.57
6cduE-3sqlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 ALA A 321
THR A 320
VAL A 295
PRO A 308
None
0.86A 6cduF-3sqlA:
undetectable
6cduJ-3sqlA:
undetectable
6cduF-3sqlA:
22.57
6cduJ-3sqlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
4 / 7 VAL A 295
PRO A 308
ALA A 321
THR A 320
None
0.83A 6cduH-3sqlA:
undetectable
6cduI-3sqlA:
undetectable
6cduH-3sqlA:
22.57
6cduI-3sqlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)
3sql GLYCOSYL HYDROLASE
FAMILY 3

(Synechococcus
sp.
PCC
7002)
5 / 11 ILE A  89
LEU A 136
GLY A 357
SER A 359
ALA A 100
None
1.27A 6ieyA-3sqlA:
undetectable
6ieyB-3sqlA:
4.2
6ieyA-3sqlA:
23.55
6ieyB-3sqlA:
23.55