SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.05A 1ddsA-3sqnA:
undetectable		 1ddsA-3sqnA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.06A 1dyiA-3sqnA:
undetectable		 1dyiA-3sqnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 315
LEU A 318
LEU A 289
HIS A 283
LEU A 282
 None
 1.28A 1g50A-3sqnA:
undetectable		 1g50A-3sqnA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A 315
LEU A 318
LEU A 289
HIS A 283
LEU A 282
 None
 1.24A 1gwrA-3sqnA:
undetectable		 1gwrA-3sqnA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.00A 1tdrA-3sqnA:
undetectable		 1tdrA-3sqnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 SER A 194
PHE A 264
LEU A 282
PHE A 261
 None
 1.03A 1wrlC-3sqnA:
2.0
1wrlD-3sqnA:
undetectable		 1wrlC-3sqnA:
10.77
1wrlD-3sqnA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A 100
GLU A  99
LEU A 112
LEU A 106
VAL A 107
 None
 1.01A 2c12C-3sqnA:
undetectable		 2c12C-3sqnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 6 LEU A  20
ILE A  70
ILE A  53
ARG A  54
 None
 0.81A 2q8hA-3sqnA:
undetectable		 2q8hA-3sqnA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A  88
ASN A  81
LEU A  97
ILE A  94
THR A  10
 None
 1.19A 3a50B-3sqnA:
undetectable		 3a50B-3sqnA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A  88
ASN A  81
LEU A  97
ILE A  94
THR A  10
 None
 1.20A 3a50C-3sqnA:
undetectable		 3a50C-3sqnA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A  88
ASN A  81
LEU A  97
ILE A  94
THR A  10
 None
 1.24A 3a50E-3sqnA:
1.5		 3a50E-3sqnA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A 140
ARG A 215
LEU A 149
HIS A 125
LEU A 122
 None
 1.11A 3dzuA-3sqnA:
undetectable		 3dzuA-3sqnA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 ALA A 387
LEU A 300
VAL A 297
LEU A 360
THR A 312
 None
 1.29A 3fl9C-3sqnA:
undetectable		 3fl9C-3sqnA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 9 ALA A 387
LEU A 300
VAL A 297
LEU A 360
THR A 312
 None
 1.38A 3fl9H-3sqnA:
undetectable		 3fl9H-3sqnA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 SER A 226
PHE A 262
SER A 332
LEU A 321
 None
 0.97A 3m0wE-3sqnA:
undetectable
3m0wF-3sqnA:
undetectable
3m0wG-3sqnA:
undetectable
3m0wH-3sqnA:
undetectable		 3m0wE-3sqnA:
14.32
3m0wF-3sqnA:
14.32
3m0wG-3sqnA:
14.32
3m0wH-3sqnA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 LYS A 128
ARG A 124
ASP A  13
 None
 1.42A 3o7wA-3sqnA:
undetectable		 3o7wA-3sqnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 TYR A 237
VAL A 191
TYR A 184
SER A 267
LEU A 320
 None
 1.33A 4a84A-3sqnA:
undetectable		 4a84A-3sqnA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 6 THR A 114
GLY A 116
ILE A  92
LEU A 112
 None
 1.24A 4ac9C-3sqnA:
4.0		 4ac9C-3sqnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 6 THR A 114
GLY A 116
ILE A  92
LEU A 112
 None
 1.17A 4acaC-3sqnA:
3.6		 4acaC-3sqnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.05A 4dfrA-3sqnA:
undetectable		 4dfrA-3sqnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 PHE A 376
LEU A 379
ALA A 380
LEU A 293
LEU A 318
 None
 1.07A 4dm8B-3sqnA:
undetectable		 4dm8B-3sqnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 117
SER A 118
THR A 121
 None
 0.42A 4luhA-3sqnA:
3.2		 4luhA-3sqnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A  88
LEU A  25
LEU A  21
TYR A   2
LEU A   5
 None
 1.08A 4odoB-3sqnA:
undetectable		 4odoB-3sqnA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 10 LEU A  88
LEU A  25
LEU A  21
TYR A   2
LEU A   5
 None
 1.06A 4odoC-3sqnA:
undetectable		 4odoC-3sqnA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.09A 4qlgB-3sqnA:
undetectable		 4qlgB-3sqnA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 VAL A 458
LEU A 476
LEU A 416
LEU A 412
LYS A 409
 None
 1.31A 4rtbA-3sqnA:
undetectable		 4rtbA-3sqnA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.10A 4x5hA-3sqnA:
undetectable		 4x5hA-3sqnA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 383
ALA A 387
LEU A 300
LEU A 309
LEU A 353
 None
 1.31A 4zn7B-3sqnA:
undetectable		 4zn7B-3sqnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.11A 5e8qB-3sqnA:
undetectable		 5e8qB-3sqnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 TYR A 274
TRP A 268
TYR A 270
LEU A 265
 None
 1.24A 5kxiA-3sqnA:
2.4
5kxiB-3sqnA:
undetectable		 5kxiA-3sqnA:
22.09
5kxiB-3sqnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 TYR A 274
TRP A 268
TYR A 270
LEU A 265
 None
 1.21A 5kxiD-3sqnA:
2.5
5kxiE-3sqnA:
undetectable		 5kxiD-3sqnA:
22.09
5kxiE-3sqnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 5 GLU A 266
GLU A 201
GLU A 338
PHE A 204
 None
 1.43A 5onlA-3sqnA:
undetectable		 5onlA-3sqnA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		5 / 12 ILE A  39
ALA A  37
THR A  31
ILE A  70
LEU A  50
 None
 1.12A 5ujxB-3sqnA:
undetectable		 5ujxB-3sqnA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ARG A 215
PHE A 136
LEU A 149
 None
 0.90A 5x1bC-3sqnA:
undetectable		 5x1bC-3sqnA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 TYR A 274
TRP A 268
THR A 200
LEU A 265
 None
 1.31A 6cnjD-3sqnA:
undetectable
6cnjE-3sqnA:
undetectable		 6cnjD-3sqnA:
9.48
6cnjE-3sqnA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 8 TYR A 274
TRP A 268
TYR A 270
LEU A 265
 None
 1.10A 6cnjD-3sqnA:
undetectable
6cnjE-3sqnA:
undetectable		 6cnjD-3sqnA:
9.48
6cnjE-3sqnA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		4 / 5 GLU A 266
GLU A 201
GLU A 338
PHE A 204
 None
 1.42A 6hrjA-3sqnA:
undetectable		 6hrjA-3sqnA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3sqn CONSERVED DOMAIN
PROTEIN
(Enterococcus
faecalis) 		3 / 3 ILE A 370
THR A 369
PRO A 373
 None
 0.66A 6ncsA-3sqnA:
undetectable		 6ncsA-3sqnA:
20.49