SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3sqo PCSK9 PRODOMAIN
(Homo
sapiens) 		4 / 8 GLU P 145
LEU P 131
ALA P 134
LEU P 135
 None
 0.86A 1hwiD-3sqoP:
4.5		 1hwiD-3sqoP:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3sqo J16 HEAVY CHAIN
(Homo
sapiens) 		4 / 6 TRP H  36
MET H  80
MET H  69
LEU H  82
 None
 1.47A 2oz7A-3sqoH:
undetectable		 2oz7A-3sqoH:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3sqo PCSK9 PRODOMAIN
(Homo
sapiens) 		5 / 10 ARG P  97
LEU P  98
LEU P 137
LEU P 131
LEU P 130
 None
 1.03A 6f6nA-3sqoP:
undetectable
6f6nB-3sqoP:
undetectable		 6f6nA-3sqoP:
20.17
6f6nB-3sqoP:
20.18