SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.14A 1c9hA-3sqwA:
undetectable		 1c9hA-3sqwA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 592
SER A 535
ILE A 534
LEU A 580
 None
U  B   3 ( 4.5A)
None
None
 0.90A 1eupA-3sqwA:
undetectable		 1eupA-3sqwA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.09A 1fkfA-3sqwA:
undetectable		 1fkfA-3sqwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.10A 1fkjA-3sqwA:
undetectable		 1fkjA-3sqwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.02A 1fklA-3sqwA:
undetectable		 1fklA-3sqwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 197
PHE A 258
MET A 228
ALA A 226
 None
 1.30A 1linA-3sqwA:
undetectable		 1linA-3sqwA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 438
LEU A 273
ASP A 270
LEU A 308
 None
 1.13A 1n13B-3sqwA:
undetectable
1n13C-3sqwA:
undetectable		 1n13B-3sqwA:
12.78
1n13C-3sqwA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 267
HIS A 462
ASP A 270
 MG  A 900 ( 3.7A)
None
None
 0.87A 1nw5A-3sqwA:
2.6		 1nw5A-3sqwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.79A 1p2yA-3sqwA:
undetectable		 1p2yA-3sqwA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 246
ALA A 193
LEU A 194
GLU A 199
LEU A 163
 None
None
None
ANP  A 800 ( 4.9A)
None
 1.30A 2azqA-3sqwA:
undetectable		 2azqA-3sqwA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 245
GLY A 244
THR A 283
ILE A 284
 U  B   8 ( 4.1A)
U  B   7 ( 3.1A)
None
None
 0.88A 2f9wA-3sqwA:
2.1
2f9wB-3sqwA:
2.8		 2f9wA-3sqwA:
17.18
2f9wB-3sqwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.11A 2fkeA-3sqwA:
undetectable		 2fkeA-3sqwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 499
ILE A 497
ALA A 338
THR A 154
ALA A 468
 None
None
None
ANP  A 800 (-4.4A)
None
 0.94A 2j0dA-3sqwA:
undetectable		 2j0dA-3sqwA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 499
ILE A 497
ALA A 338
THR A 154
GLU A 447
 None
None
None
ANP  A 800 (-4.4A)
None
 1.18A 2j0dA-3sqwA:
undetectable		 2j0dA-3sqwA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 SER A 345
LYS A 501
SER A 475
VAL A 477
 None
 0.94A 2j9cA-3sqwA:
0.0
2j9cB-3sqwA:
undetectable
2j9cC-3sqwA:
undetectable		 2j9cA-3sqwA:
12.61
2j9cB-3sqwA:
12.61
2j9cC-3sqwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 1.01A 3dzyD-3sqwA:
undetectable		 3dzyD-3sqwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 469
GLU A 340
ASP A 332
 ANP  A 800 (-2.7A)
None
None
 0.94A 3g2oA-3sqwA:
3.5		 3g2oA-3sqwA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.05A 3kvrA-3sqwA:
2.4		 3kvrA-3sqwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.13A 3kvrB-3sqwA:
2.4		 3kvrB-3sqwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 SER A 470
PHE A 126
ILE A 203
GLU A 199
LEU A 163
 ANP  A 800 (-3.7A)
ANP  A 800 (-3.5A)
None
ANP  A 800 ( 4.9A)
None
 1.39A 3m0wC-3sqwA:
undetectable
3m0wD-3sqwA:
undetectable
3m0wE-3sqwA:
undetectable
3m0wF-3sqwA:
undetectable		 3m0wC-3sqwA:
11.98
3m0wD-3sqwA:
11.98
3m0wE-3sqwA:
11.98
3m0wF-3sqwA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.07A 3nbqA-3sqwA:
2.6		 3nbqA-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.88A 3nbqB-3sqwA:
undetectable		 3nbqB-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.90A 3nbqC-3sqwA:
undetectable		 3nbqC-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_D_URFD400_1
(URIDINE
PHOSPHORYLASE 1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.09A 3nbqD-3sqwA:
undetectable		 3nbqD-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 120
LEU A 113
ILE A 164
ALA A 161
THR A 136
 None
 1.36A 3r9cA-3sqwA:
undetectable		 3r9cA-3sqwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.04A 3vawA-3sqwA:
undetectable		 3vawA-3sqwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.17A 4a97I-3sqwA:
undetectable		 4a97I-3sqwA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.21A 4drhA-3sqwA:
undetectable		 4drhA-3sqwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.05A 4driA-3sqwA:
undetectable		 4driA-3sqwA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.11A 4drjA-3sqwA:
undetectable		 4drjA-3sqwA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 537
ASN A 354
GLU A 554
GLU A 484
 None
 1.09A 4mi4A-3sqwA:
undetectable
4mi4C-3sqwA:
undetectable		 4mi4A-3sqwA:
16.09
4mi4C-3sqwA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 244
PRO A 243
ALA A 187
 U  B   7 ( 3.1A)
U  B   6 ( 3.9A)
None
 0.52A 4qn9B-3sqwA:
undetectable		 4qn9B-3sqwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.04A 4qt2A-3sqwA:
undetectable		 4qt2A-3sqwA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.17A 4qt3A-3sqwA:
undetectable		 4qt3A-3sqwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 MET A 440
GLN A 450
TYR A 460
 None
 1.13A 4udcA-3sqwA:
undetectable		 4udcA-3sqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 1.02A 4wnvD-3sqwA:
undetectable		 4wnvD-3sqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 196
ALA A 183
VAL A 265
VAL A 200
 None
 0.75A 5ecnD-3sqwA:
0.9		 5ecnD-3sqwA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.12A 5hkgA-3sqwA:
undetectable		 5hkgA-3sqwA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 469
HIS A 462
ARG A 466
 ANP  A 800 (-2.7A)
None
ANP  A 800 (-2.5A)
 1.12A 5iaoC-3sqwA:
2.7		 5iaoC-3sqwA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 469
HIS A 462
ARG A 466
 ANP  A 800 (-2.7A)
None
ANP  A 800 (-2.5A)
 1.15A 5iaoF-3sqwA:
2.7		 5iaoF-3sqwA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 LYS A  95
THR A 156
PRO A 336
ILE A 461
 None
ANP  A 800 (-4.7A)
None
None
 1.09A 5jhdE-3sqwA:
undetectable
5jhdG-3sqwA:
undetectable		 5jhdE-3sqwA:
17.87
5jhdG-3sqwA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 530
THR A 558
PHE A 592
LEU A 577
VAL A 572
 None
 1.34A 6a93B-3sqwA:
undetectable		 6a93B-3sqwA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 436
ASP A 434
ARG A 466
ARG A 463
 None
None
ANP  A 800 (-2.5A)
None
 1.39A 6dwdB-3sqwA:
undetectable
6dwdD-3sqwA:
undetectable		 6dwdB-3sqwA:
22.45
6dwdD-3sqwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 466
ARG A 463
GLY A 436
ASP A 434
 ANP  A 800 (-2.5A)
None
None
None
 1.41A 6dwjB-3sqwA:
undetectable
6dwjD-3sqwA:
undetectable		 6dwjB-3sqwA:
22.45
6dwjD-3sqwA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 343
VAL A 498
ILE A 497
TYR A 460
ILE A 464
 None
 1.15A 6mkeC-3sqwA:
undetectable		 6mkeC-3sqwA:
10.52