SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3sr2 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		5 / 9 PHE A  32
VAL A  22
LEU A  75
PHE A 111
LEU A  28
 None
 1.37A 1wrkA-3sr2A:
undetectable
1wrkB-3sr2A:
undetectable		 1wrkA-3sr2A:
19.71
1wrkB-3sr2A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3sr2 NON-HOMOLOGOUS
END-JOINING FACTOR 1
(Homo
sapiens) 		4 / 6 LEU C   8
LYS C  26
LEU C  37
PRO C 138
 None
 1.14A 2dqyC-3sr2C:
undetectable		 2dqyC-3sr2C:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3sr2 NON-HOMOLOGOUS
END-JOINING FACTOR 1
(Homo
sapiens) 		5 / 12 TRP C  13
PHE C 210
ILE C 204
ASP C  40
LEU C  41
 None
 1.02A 3iv6D-3sr2C:
undetectable		 3iv6D-3sr2C:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3sr2 NON-HOMOLOGOUS
END-JOINING FACTOR 1
(Homo
sapiens) 		5 / 12 LEU C 104
GLU C  47
LEU C  36
LEU C  80
VAL C 108
 None
 1.06A 3ix9B-3sr2C:
undetectable		 3ix9B-3sr2C:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3sr2 DNA REPAIR PROTEIN
XRCC4
(Homo
sapiens) 		3 / 3 ASN A 118
ALA A 120
ARG A 124
 None
 0.69A 5cvtB-3sr2A:
undetectable		 5cvtB-3sr2A:
24.88