SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sr3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 7 TYR A  16
HIS A 303
TYR A 111
GLY A 209
 None
 1.16A 1mxgA-3sr3A:
undetectable		 1mxgA-3sr3A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 THR A 213
TRP A 218
LEU A 119
MET A 223
 None
 1.48A 1uw6D-3sr3A:
undetectable
1uw6E-3sr3A:
undetectable		 1uw6D-3sr3A:
20.83
1uw6E-3sr3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 THR A 213
TRP A 218
LEU A 119
MET A 223
 None
 1.47A 1uw6G-3sr3A:
undetectable
1uw6H-3sr3A:
undetectable		 1uw6G-3sr3A:
20.83
1uw6H-3sr3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 THR A 213
TRP A 218
LEU A 119
MET A 223
 None
 1.45A 1uw6P-3sr3A:
undetectable
1uw6Q-3sr3A:
undetectable		 1uw6P-3sr3A:
20.83
1uw6Q-3sr3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 TRP A 218
LEU A 119
MET A 223
THR A 213
 None
 1.46A 1uw6P-3sr3A:
undetectable
1uw6T-3sr3A:
undetectable		 1uw6P-3sr3A:
20.83
1uw6T-3sr3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 8 ILE A 167
ILE A 327
ARG A 205
ILE A 308
VAL A 314
 None
 1.39A 2nniA-3sr3A:
undetectable		 2nniA-3sr3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 10 ILE A 293
LEU A 265
ILE A 263
PHE A 257
THR A 198
 None
 1.05A 2w9sD-3sr3A:
undetectable		 2w9sD-3sr3A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 5 PRO A   4
ILE A 127
PRO A   2
TYR A 122
 None
 1.34A 3d9lA-3sr3A:
undetectable
3d9lY-3sr3A:
undetectable		 3d9lA-3sr3A:
18.98
3d9lY-3sr3A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 6 ILE A 231
MET A 310
ILE A 327
HIS A 326
 None
 1.16A 3eteA-3sr3A:
3.6
3eteE-3sr3A:
3.6		 3eteA-3sr3A:
22.04
3eteE-3sr3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 5 ILE A 231
MET A 310
ILE A 327
HIS A 326
 None
 1.17A 3eteB-3sr3A:
3.5
3eteC-3sr3A:
3.5		 3eteB-3sr3A:
22.04
3eteC-3sr3A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 5 ILE A  84
THR A  23
GLU A  67
GLU A  46
 None
 1.41A 3ny4A-3sr3A:
undetectable		 3ny4A-3sr3A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 7 GLY A  85
GLY A  86
SER A 112
HIS A 303
 None
 0.70A 3o9mA-3sr3A:
undetectable		 3o9mA-3sr3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 6 GLY A  85
GLY A  86
SER A 112
HIS A 303
 None
 0.75A 3o9mB-3sr3A:
3.4		 3o9mB-3sr3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 ASP A 240
ASP A 272
GLU A 245
GLU A 286
 None
 1.02A 3sg9B-3sr3A:
undetectable		 3sg9B-3sr3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 7 ASN A  90
LEU A  92
GLY A  86
SER A  20
 None
 1.00A 4cp3A-3sr3A:
undetectable
4cp3B-3sr3A:
undetectable		 4cp3A-3sr3A:
13.73
4cp3B-3sr3A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 8 GLY A  14
LEU A  45
ILE A  44
THR A  83
 None
 0.87A 4em2A-3sr3A:
undetectable		 4em2A-3sr3A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		3 / 3 PRO A 224
TYR A 122
GLY A 120
 None
 0.70A 4g2zA-3sr3A:
undetectable		 4g2zA-3sr3A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 12 ILE A 293
ILE A 226
PHE A 257
LEU A 211
ILE A 263
 None
 1.04A 4km0B-3sr3A:
undetectable		 4km0B-3sr3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 6 TYR A   9
TYR A 150
LEU A  37
PHE A 153
 None
 1.09A 4twdB-3sr3A:
undetectable
4twdC-3sr3A:
undetectable		 4twdB-3sr3A:
20.51
4twdC-3sr3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 6 TYR A   9
TYR A 150
LEU A  37
PHE A 153
 None
 1.11A 4twdD-3sr3A:
undetectable
4twdE-3sr3A:
undetectable		 4twdD-3sr3A:
20.51
4twdE-3sr3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 7 TYR A 150
LEU A  37
PHE A 153
TYR A   9
 None
 1.02A 4twdF-3sr3A:
undetectable
4twdJ-3sr3A:
undetectable		 4twdF-3sr3A:
20.51
4twdJ-3sr3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		4 / 6 TYR A   9
TYR A 150
LEU A  37
PHE A 153
 None
 1.06A 4twdF-3sr3A:
undetectable
4twdG-3sr3A:
undetectable		 4twdF-3sr3A:
20.51
4twdG-3sr3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 12 GLY A  85
TYR A  56
ALA A 134
ASP A 113
ALA A 114
 None
 1.34A 4ymgB-3sr3A:
undetectable		 4ymgB-3sr3A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 12 SER A  82
ASN A 210
LEU A 118
LEU A 119
LEU A 117
 None
 1.26A 5nwwA-3sr3A:
undetectable		 5nwwA-3sr3A:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3sr3 MICROCIN IMMUNITY
PROTEIN MCCF
(Bacillus
anthracis) 		5 / 10 ILE A 234
LEU A 119
ASP A 236
THR A 115
THR A 243
 None
 1.42A 6b4yA-3sr3A:
0.1		 6b4yA-3sr3A:
22.19