SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.94A 1c9sN-3sr6C:
undetectable
1c9sO-3sr6C:
undetectable
1c9sN-3sr6C:
7.93
1c9sO-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.92A 1c9sP-3sr6C:
undetectable
1c9sQ-3sr6C:
undetectable
1c9sP-3sr6C:
7.93
1c9sQ-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 GLY C 915
GLY C1006
HIS C 884
ALA C1079
ILE C1007
None
None
None
RMO  C1317 ( 3.6A)
None
0.93A 1c9sL-3sr6C:
undetectable
1c9sV-3sr6C:
undetectable
1c9sL-3sr6C:
7.93
1c9sV-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 ILE C1097
ARG C1100
TYR C1024
VAL C1090
None
0.91A 1db1A-3sr6C:
undetectable
1db1A-3sr6C:
17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.31A 1fo4A-3sr6C:
52.6
1fo4A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.20A 1fo4A-3sr6C:
52.6
1fo4A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
7 / 7 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1078
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
0.24A 1fo4B-3sr6C:
41.7
1fo4B-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 SER C 876
PHE C 914
VAL C1011
ALA C1079
None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
0.98A 1fo4B-3sr6C:
41.7
1fo4B-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.94A 1gtfQ-3sr6C:
undetectable
1gtfR-3sr6C:
undetectable
1gtfQ-3sr6C:
7.93
1gtfR-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.93A 1gtfS-3sr6C:
undetectable
1gtfT-3sr6C:
undetectable
1gtfS-3sr6C:
7.93
1gtfT-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.94A 1gtnT-3sr6C:
undetectable
1gtnU-3sr6C:
undetectable
1gtnT-3sr6C:
7.93
1gtnU-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLY C 915
GLY C1006
HIS C 884
ALA C1079
ILE C1007
None
None
None
RMO  C1317 ( 3.6A)
None
0.95A 1gtnL-3sr6C:
undetectable
1gtnV-3sr6C:
undetectable
1gtnL-3sr6C:
7.93
1gtnV-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1039
GLY C1041
GLU C1037
ARG C 793
GLY C 795
MTE  C1316 (-3.3A)
None
None
None
None
0.97A 1jg3A-3sr6C:
undetectable
1jg3A-3sr6C:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1039
GLY C1041
GLU C1037
ARG C 793
GLY C 795
MTE  C1316 (-3.3A)
None
None
None
None
0.95A 1jg3B-3sr6C:
undetectable
1jg3B-3sr6C:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ASP C1026
GLU C1114
ILE C1056
PRO C1057
ILE C1061
None
1.14A 1kijA-3sr6C:
4.0
1kijA-3sr6C:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 ASP C 638
GLY C 668
ILE C 666
ALA C 813
None
0.74A 1n49A-3sr6C:
undetectable
1n49A-3sr6C:
10.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
11 / 12 LEU C 648
ASN C 768
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1078
ALA C1079
None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.35A 1n5xA-3sr6C:
65.9
1n5xA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
10 / 12 LEU C 648
LYS C 771
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1079
None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 ( 3.6A)
0.77A 1n5xA-3sr6C:
65.9
1n5xA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 LEU C 873
SER C 876
PHE C 914
VAL C1011
ALA C1079
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
1.11A 1n5xA-3sr6C:
65.9
1n5xA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
11 / 12 LEU C 648
ASN C 768
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1078
ALA C1079
None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.35A 1n5xB-3sr6C:
65.9
1n5xB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
10 / 12 LEU C 648
LYS C 771
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1079
None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 ( 3.6A)
0.77A 1n5xB-3sr6C:
65.9
1n5xB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 LEU C 873
SER C 876
PHE C 914
VAL C1011
ALA C1079
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
1.11A 1n5xB-3sr6C:
65.9
1n5xB-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 LEU C1243
ILE C1178
PHE C1199
GLY C1193
PHE C1239
None
1.30A 1td7A-3sr6C:
undetectable
1td7A-3sr6C:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.95A 1utdO-3sr6C:
undetectable
1utdP-3sr6C:
undetectable
1utdO-3sr6C:
7.93
1utdP-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.95A 1utdP-3sr6C:
undetectable
1utdQ-3sr6C:
undetectable
1utdP-3sr6C:
7.93
1utdQ-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_S_TRPS81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.92A 1utdS-3sr6C:
undetectable
1utdT-3sr6C:
undetectable
1utdS-3sr6C:
7.93
1utdT-3sr6C:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 GLY C1006
HIS C 884
ALA C1079
ILE C1007
GLY C 915
None
None
RMO  C1317 ( 3.6A)
None
None
0.96A 1utdU-3sr6C:
undetectable
1utdV-3sr6C:
undetectable
1utdU-3sr6C:
7.93
1utdV-3sr6C:
7.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 10 GLU C 802
LEU C 873
ARG C 880
PHE C 914
PHE C1009
THR C1010
ALA C1078
ALA C1079
GLU C1261
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
RMO  C1317 (-3.4A)
0.38A 1wygA-3sr6C:
55.3
1wygA-3sr6C:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WYG_A_SALA4005_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 10 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
PHE C1009
ALA C1078
ALA C1079
GLU C1261
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
RMO  C1317 (-3.4A)
0.35A 1wygA-3sr6C:
55.3
1wygA-3sr6C:
59.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
6 / 6 ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.40A 2e1qA-3sr6C:
53.4
2e1qA-3sr6C:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_B_SALB3006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 4 ARG C 880
PHE C 914
THR C1010
ALA C1079
None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
0.34A 2e1qB-3sr6C:
53.5
2e1qB-3sr6C:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
6 / 6 ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.34A 2e1qC-3sr6C:
64.8
2e1qC-3sr6C:
61.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 5 ARG C 880
PHE C 914
THR C1010
LEU C1014
ALA C1079
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 ( 3.6A)
0.35A 2e1qD-3sr6C:
62.3
2e1qD-3sr6C:
61.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 LEU C1186
VAL C1023
VAL C1090
ILE C1061
None
1.24A 2hyyB-3sr6C:
undetectable
2hyyB-3sr6C:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C1274
ILE C1164
ALA C1281
THR C1286
GLU C 929
None
1.15A 2j0dA-3sr6C:
undetectable
2j0dA-3sr6C:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 PHE C1009
ILE C1085
GLY C1035
GLY C1034
None
0.80A 2qx6A-3sr6C:
undetectable
2qx6B-3sr6C:
undetectable
2qx6A-3sr6C:
15.56
2qx6B-3sr6C:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 PHE C1206
ILE C 736
GLY C 916
GLY C 915
None
0.83A 2qx6A-3sr6C:
undetectable
2qx6B-3sr6C:
undetectable
2qx6A-3sr6C:
15.56
2qx6B-3sr6C:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 ALA C 811
ALA C 815
THR C 819
LEU C 603
VAL C 632
None
1.29A 2wuzA-3sr6C:
undetectable
2wuzA-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 ALA C 811
ALA C 815
THR C 819
LEU C 603
VAL C 632
None
1.29A 2wuzB-3sr6C:
undetectable
2wuzB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 GLN C 918
PHE C 914
GLY C 915
GLY C 800
None
RMO  C1317 (-3.6A)
None
None
0.85A 2y6rB-3sr6C:
undetectable
2y6rB-3sr6C:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 ILE C1007
ARG C 880
PRO C1262
VAL C 764
None
1.10A 2ygoA-3sr6C:
undetectable
2ygoA-3sr6C:
12.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
8 / 8 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.17A 3ax7A-3sr6C:
61.6
3ax7A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 8 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.11A 3ax7A-3sr6C:
61.6
3ax7A-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1078
ALA C1079
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.24A 3ax7B-3sr6C:
63.0
3ax7B-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
8 / 8 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
ALA C1078
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.24A 3ax9B-3sr6C:
66.1
3ax9B-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
3 / 3 SER C 765
GLY C 795
GLY C 797
None
None
MTE  C1316 (-3.5A)
0.57A 3bogA-3sr6C:
undetectable
3bogC-3sr6C:
undetectable
3bogA-3sr6C:
undetectable
3bogC-3sr6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 THR C 803
VAL C 810
LEU C 762
ILE C 787
GLY C 647
None
1.17A 3cv9A-3sr6C:
undetectable
3cv9A-3sr6C:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
3 / 3 MET C 927
CYH C 999
PRO C1002
None
0.89A 3h52C-3sr6C:
undetectable
3h52C-3sr6C:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C1253
GLY C1087
ALA C1019
ALA C1050
VAL C1049
None
0.77A 3jb2A-3sr6C:
undetectable
3jb2A-3sr6C:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C1253
GLY C1087
ALA C1019
ALA C1050
VAL C1049
None
0.69A 3jb3A-3sr6C:
undetectable
3jb3A-3sr6C:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLN C 767
GLY C 795
GLY C 797
LEU C 744
GLU C1037
RMO  C1317 (-3.6A)
None
MTE  C1316 (-3.5A)
None
None
1.09A 3kkzA-3sr6C:
undetectable
3kkzA-3sr6C:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 PHE C 655
ALA C 811
ALA C 815
THR C 819
None
0.81A 3l4dA-3sr6C:
undetectable
3l4dA-3sr6C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 PHE C 655
ALA C 811
ALA C 815
THR C 819
None
0.89A 3l4dD-3sr6C:
undetectable
3l4dD-3sr6C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
3 / 3 ARG C1279
VAL C1310
THR C1286
None
0.86A 3nduD-3sr6C:
undetectable
3nduD-3sr6C:
9.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
6 / 6 GLU C 802
ARG C 880
PHE C 914
THR C1010
ALA C1078
ALA C1079
RMO  C1317 (-4.4A)
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.25A 3ns1C-3sr6C:
67.2
3ns1C-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
8 / 8 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
LEU C1014
ALA C1078
ALA C1079
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
0.23A 3ns1L-3sr6C:
57.6
3ns1L-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 ALA C 669
VAL C 823
VAL C 671
LEU C 635
None
0.76A 3o14A-3sr6C:
undetectable
3o14A-3sr6C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C1056
VAL C1023
ILE C1021
CYH C1094
LEU C1098
None
0.55A 3oapA-3sr6C:
undetectable
3oapA-3sr6C:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 ILE C1097
SER C1051
ILE C1061
VAL C1029
VAL C1031
None
1.37A 3rf4A-3sr6C:
0.5
3rf4B-3sr6C:
0.5
3rf4A-3sr6C:
9.42
3rf4B-3sr6C:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
3 / 3 ARG C1279
VAL C1310
THR C1286
None
0.86A 3tl9A-3sr6C:
undetectable
3tl9A-3sr6C:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.24A 3unaA-3sr6C:
67.3
3unaA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_A_SALA1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.20A 3unaA-3sr6C:
67.3
3unaA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.22A 3unaB-3sr6C:
61.3
3unaB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNA_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.18A 3unaB-3sr6C:
61.3
3unaB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.21A 3uncA-3sr6C:
65.7
3uncA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_A_SALA1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.16A 3uncA-3sr6C:
65.7
3uncA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
9 / 9 GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.22A 3uncB-3sr6C:
56.8
3uncB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNC_B_SALB1338_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 9 SER C 876
PHE C 914
VAL C1011
LEU C1014
ALA C1078
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
1.16A 3uncB-3sr6C:
56.8
3uncB-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
7 / 7 GLU C 802
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.23A 3uniA-3sr6C:
61.3
3uniA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
8 / 8 GLU C 802
LEU C 873
ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
0.24A 3uniB-3sr6C:
69.6
3uniB-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C1056
VAL C1023
ILE C1021
CYH C1094
LEU C1098
None
0.61A 3uvvB-3sr6C:
undetectable
3uvvB-3sr6C:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 GLN C 918
PHE C 914
GLY C 915
GLY C 800
None
RMO  C1317 (-3.6A)
None
None
0.80A 3v3nB-3sr6C:
undetectable
3v3nB-3sr6C:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 GLN C 918
PHE C 914
GLY C 915
GLY C 800
None
RMO  C1317 (-3.6A)
None
None
0.79A 3v3nC-3sr6C:
undetectable
3v3nC-3sr6C:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 ASN C1249
CYH C1247
GLY C1183
ASP C1181
None
1.31A 3w9tE-3sr6C:
undetectable
3w9tE-3sr6C:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 5 VAL C1029
LEU C1054
ILE C1056
VAL C1117
None
0.99A 4a9kB-3sr6C:
undetectable
4a9kB-3sr6C:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ALA C1089
LEU C1020
SER C1032
VAL C1031
ILE C1061
None
0.88A 4azvA-3sr6C:
undetectable
4azvA-3sr6C:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 VAL C 789
THR C1070
ALA C 769
THR C 772
VAL C 764
None
1.15A 4e0fA-3sr6C:
undetectable
4e0fA-3sr6C:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 5 SER C1185
GLY C 574
THR C1083
VAL C1049
None
1.12A 4eohA-3sr6C:
undetectable
4eohA-3sr6C:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLY C1267
GLY C1202
ALA C1198
ALA C1158
PHE C1271
None
1.13A 4kicA-3sr6C:
undetectable
4kicA-3sr6C:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 TYR C 817
VAL C 782
ILE C 787
ALA C 813
None
0.84A 4lv9A-3sr6C:
undetectable
4lv9A-3sr6C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 GLU C1065
THR C1066
THR C1044
HIS C 579
None
1.10A 4pfjA-3sr6C:
undetectable
4pfjA-3sr6C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 GLU C1065
THR C1066
THR C1044
HIS C 579
None
0.97A 4pfjB-3sr6C:
undetectable
4pfjB-3sr6C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 ALA C1198
ASN C 887
THR C1154
SER C1080
None
None
None
MTE  C1316 (-4.3A)
0.74A 4r20A-3sr6C:
undetectable
4r20A-3sr6C:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ALA C1258
GLY C1006
GLU C 802
ALA C 910
GLY C 913
None
None
RMO  C1317 (-4.4A)
RMO  C1317 ( 4.0A)
None
1.05A 4r29B-3sr6C:
undetectable
4r29B-3sr6C:
16.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 ASP C 571
SER C1051
PRO C1057
TRP C1113
None
1.00A 4uhxA-3sr6C:
45.3
4uhxA-3sr6C:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 ASP C 571
SER C1051
PRO C1057
TRP C1116
None
0.56A 4uhxA-3sr6C:
45.3
4uhxA-3sr6C:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 8 ASP C 571
SER C1051
PRO C1057
TRP C1113
None
1.00A 4uhxA-3sr6C:
45.3
4uhxA-3sr6C:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 ILE C1063
VAL C1071
THR C1077
ARG C 793
None
0.92A 4xe5A-3sr6C:
undetectable
4xe5A-3sr6C:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 TYR C1254
ALA C1258
ALA C1252
ASN C1249
TYR C1152
None
1.41A 4ymgA-3sr6C:
undetectable
4ymgA-3sr6C:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 7 TYR C1213
GLY C 664
SER C 906
LEU C 905
None
1.06A 5bphB-3sr6C:
undetectable
5bphB-3sr6C:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 LEU C 959
TYR C 947
ASN C1145
PHE C 883
ILE C 714
None
1.48A 5dv4A-3sr6C:
undetectable
5dv4A-3sr6C:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
None
1.29A 5hnxB-3sr6C:
undetectable
5hnxB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
None
1.30A 5hnzB-3sr6C:
undetectable
5hnzB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
3 / 3 VAL C 789
SER C 805
MET C 826
None
0.88A 5ikqA-3sr6C:
undetectable
5ikqA-3sr6C:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 GLU C 929
SER C 928
PHE C1271
THR C1301
ARG C1306
None
1.24A 5ogcB-3sr6C:
undetectable
5ogcB-3sr6C:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 PHE C 911
ALA C1198
LEU C1264
GLY C 913
ILE C1274
None
1.23A 5oy01-3sr6C:
undetectable
5oy07-3sr6C:
undetectable
5oy01-3sr6C:
7.99
5oy07-3sr6C:
4.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 6 VAL C 687
LYS C 618
ILE C 667
LYS C 616
None
1.42A 5q1sA-3sr6C:
undetectable
5q1sA-3sr6C:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 PHE C1013
PHE C1009
ALA C1079
THR C 803
LEU C 648
None
None
RMO  C1317 ( 3.6A)
None
None
1.13A 5tl8A-3sr6C:
undetectable
5tl8A-3sr6C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 ILE C 640
GLY C 642
GLY C 781
SER C 809
VAL C 654
None
0.95A 5twjA-3sr6C:
undetectable
5twjA-3sr6C:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 10 ILE C 640
GLY C 642
GLY C 781
SER C 809
VAL C 654
None
0.93A 5twjB-3sr6C:
undetectable
5twjB-3sr6C:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 11 ILE C 640
GLY C 642
GLY C 781
SER C 809
VAL C 654
None
0.95A 5twjD-3sr6C:
undetectable
5twjD-3sr6C:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 PHE C1013
PHE C1009
ALA C1079
THR C 803
LEU C 648
None
None
RMO  C1317 ( 3.6A)
None
None
1.21A 6aybA-3sr6C:
undetectable
6aybA-3sr6C:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
5 / 12 PHE C1013
PHE C1009
ALA C1079
THR C 803
LEU C 648
None
None
RMO  C1317 ( 3.6A)
None
None
1.12A 6aycA-3sr6C:
undetectable
6aycA-3sr6C:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos
taurus)
4 / 5 LEU C 900
CYH C 901
THR C 903
GLY C 868
None
0.97A 6gtqA-3sr6C:
undetectable
6gtqA-3sr6C:
14.70