SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3srz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 ASP A  77
LEU A  12
LEU A  74
 None
 0.75A 1np1B-3srzA:
undetectable		 1np1B-3srzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 7 PHE A  58
LEU A  71
THR A  25
TYR A  23
 None
 1.12A 1rmtB-3srzA:
undetectable		 1rmtB-3srzA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 8 PHE A  58
LEU A  71
THR A  25
TYR A  23
 None
 1.11A 1rmtD-3srzA:
undetectable		 1rmtD-3srzA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A 273
LEU A 276
GLU A  94
VAL A 367
ILE A 399
 None
 1.13A 1s9pA-3srzA:
undetectable		 1s9pA-3srzA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 5 ASP A 202
THR A 139
LEU A 140
LEU A 136
 None
 1.14A 1u18B-3srzA:
undetectable		 1u18B-3srzA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 LEU A 446
PHE A 445
ARG A 261
 None
 0.70A 1xdkF-3srzA:
undetectable		 1xdkF-3srzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 8 ILE A 481
PHE A 500
LEU A 497
ILE A 498
 None
 0.93A 2azxA-3srzA:
undetectable		 2azxA-3srzA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 5 GLN A 256
THR A 427
HIS A 431
LEU A 434
 None
 1.19A 3ce6A-3srzA:
undetectable		 3ce6A-3srzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 5 LEU A 453
GLN A 256
HIS A 431
LEU A 434
 None
 1.21A 3ce6D-3srzA:
undetectable		 3ce6D-3srzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 6 LEU A 507
TRP A 117
SER A 508
PHE A 359
 None
 1.48A 3i9jB-3srzA:
undetectable		 3i9jB-3srzA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 GLU A 176
ASP A 180
ASP A 425
 None
 0.68A 3jb2A-3srzA:
undetectable		 3jb2A-3srzA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.06A 3mteA-3srzA:
undetectable		 3mteA-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.93A 3mteB-3srzA:
undetectable		 3mteB-3srzA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 11 PHE A 435
PHE A 430
HIS A 431
LEU A 446
ILE A 449
 None
 1.24A 3o94D-3srzA:
undetectable		 3o94D-3srzA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.92A 3p2kA-3srzA:
undetectable		 3p2kA-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
VAL A 455
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 1.11A 3p2kB-3srzA:
undetectable		 3p2kB-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.96A 3p2kC-3srzA:
undetectable		 3p2kC-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 GLY A 262
ALA A 266
ALA A 267
LEU A 140
LEU A 264
 None
None
None
None
UPG  A 556 (-3.9A)
 0.90A 3p2kD-3srzA:
undetectable		 3p2kD-3srzA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A 285
ALA A 265
ILE A 372
ARG A 272
ASP A 269
 UPG  A 556 (-2.8A)
UPG  A 556 (-3.7A)
None
UPG  A 556 (-2.9A)
UPG  A 556 (-2.9A)
 1.35A 3w37A-3srzA:
undetectable		 3w37A-3srzA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 ASP A 285
ALA A 265
ILE A 372
ARG A 272
ASP A 269
 UPG  A 556 (-2.8A)
UPG  A 556 (-3.7A)
None
UPG  A 556 (-2.9A)
UPG  A 556 (-2.9A)
 1.35A 3welA-3srzA:
undetectable		 3welA-3srzA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 8 ASN A 333
MET A 313
GLU A 512
GLU A 332
 None
 1.21A 4mj8A-3srzA:
undetectable
4mj8C-3srzA:
undetectable		 4mj8A-3srzA:
16.03
4mj8C-3srzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 7 ASN A 333
MET A 313
GLU A 512
GLU A 332
 None
 1.24A 4mj8C-3srzA:
undetectable		 4mj8C-3srzA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 4 LEU A 409
ILE A 253
ARG A 261
TYR A 406
 None
 1.44A 4zzcA-3srzA:
6.2		 4zzcA-3srzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 4 LEU A 409
ILE A 253
ARG A 261
TYR A 406
 None
 1.41A 4zzcB-3srzA:
6.2		 4zzcB-3srzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 4 TYR A 329
GLY A 291
SER A 508
LEU A 289
 None
 1.24A 5bphC-3srzA:
undetectable		 5bphC-3srzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 3srz TOXIN A
(Clostridioides
difficile) 		4 / 6 TYR A 329
GLY A 291
SER A 508
LEU A 289
 None
 1.23A 5bphD-3srzA:
undetectable		 5bphD-3srzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 ASP A 522
ASN A 516
PHE A 530
 None
 0.91A 5jglB-3srzA:
undetectable		 5jglB-3srzA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3srz TOXIN A
(Clostridioides
difficile) 		5 / 12 LEU A 507
GLN A 509
ARG A 272
ASN A 383
ILE A 374
 None
None
UPG  A 556 (-2.9A)
UPG  A 556 (-3.7A)
None
 1.39A 5uhbC-3srzA:
1.4		 5uhbC-3srzA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 LYS A  44
ASN A  41
SER A  88
 None
 1.27A 5yw0A-3srzA:
undetectable		 5yw0A-3srzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 3srz TOXIN A
(Clostridioides
difficile) 		3 / 3 TYR A  23
ALA A  70
LEU A   9
 None
 0.61A 6d9kF-3srzA:
undetectable		 6d9kF-3srzA:
18.99