SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ssm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 7 VAL A 353
VAL A 294
TYR A 300
LEU A 330
LEU A 333
 None
 1.33A 1cqpA-3ssmA:
undetectable
1cqpB-3ssmA:
undetectable		 1cqpA-3ssmA:
17.53
1cqpB-3ssmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.71A 1eizA-3ssmA:
13.0		 1eizA-3ssmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.76A 1ej0A-3ssmA:
13.1		 1ej0A-3ssmA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 8 GLN A 197
LEU A  29
TYR A  33
LEU A  41
 None
 1.08A 1hk3A-3ssmA:
undetectable		 1hk3A-3ssmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLU A 202
GLY A 204
GLY A 206
ILE A 235
ASP A 252
 SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
SAH  A 601 (-3.6A)
 0.82A 1qaoA-3ssmA:
9.2		 1qaoA-3ssmA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 7 LEU A 106
PHE A 110
GLY A 111
THR A 113
 None
 1.01A 2bdmA-3ssmA:
undetectable		 2bdmA-3ssmA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLU A 202
GLY A 204
SER A 217
ASP A 234
ASP A 252
 SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
 1.01A 2bm9B-3ssmA:
12.1		 2bm9B-3ssmA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 LYS A 175
ASP A 234
ASP A 252
 SAH  A 601 (-3.1A)
SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
 0.70A 2br4A-3ssmA:
12.4		 2br4A-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 4 LYS A 175
GLU A 202
SER A 217
ASP A 234
 SAH  A 601 (-3.1A)
SAH  A 601 (-3.4A)
SAH  A 601 (-3.2A)
SAH  A 601 (-2.8A)
 0.76A 2br4C-3ssmA:
12.5		 2br4C-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 LYS A 175
ASP A 252
ASP A 275
 SAH  A 601 (-3.1A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.90A 2br4D-3ssmA:
12.4		 2br4D-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 LYS A 175
GLU A 202
GLY A 204
ASP A 252
ASP A 275
 SAH  A 601 (-3.1A)
SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 1.04A 2br4E-3ssmA:
12.1		 2br4E-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLU A 202
GLY A 204
SER A 217
ASP A 252
ASP A 275
 SAH  A 601 (-3.4A)
SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.99A 2br4F-3ssmA:
12.2		 2br4F-3ssmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.53A 2igtA-3ssmA:
11.0		 2igtA-3ssmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.57A 2igtB-3ssmA:
11.0		 2igtB-3ssmA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 192
ARG A 194
ARG A 191
 None
 0.79A 2j9dA-3ssmA:
undetectable
2j9dC-3ssmA:
undetectable		 2j9dA-3ssmA:
15.22
2j9dC-3ssmA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 6 GLY A 204
SER A 217
ILE A 235
ASP A 275
 SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-3.8A)
MG  A 501 ( 2.8A)
 0.55A 3a7eA-3ssmA:
12.7		 3a7eA-3ssmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 7 VAL A  16
GLN A 229
GLY A 267
ARG A 265
 None
 0.84A 3bjwB-3ssmA:
undetectable		 3bjwB-3ssmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 6 VAL A  16
GLN A 229
GLY A 267
ARG A 265
 None
 0.82A 3bjwE-3ssmA:
undetectable		 3bjwE-3ssmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 7 VAL A  16
GLN A 229
GLY A 267
ARG A 265
 None
 0.79A 3bjwH-3ssmA:
undetectable		 3bjwH-3ssmA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 4 VAL A  15
ARG A  40
ILE A  46
THR A  30
 None
 1.35A 3cl9A-3ssmA:
2.8		 3cl9A-3ssmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 ASP A 234
ASP A 252
ASP A 275
 SAH  A 601 (-2.8A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.64A 3douA-3ssmA:
12.2		 3douA-3ssmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 8 ASP A 274
SER A 286
ASP A 275
TYR A 208
 None
None
MG  A 501 ( 2.8A)
SAH  A 601 (-3.5A)
 1.25A 3havA-3ssmA:
undetectable		 3havA-3ssmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLY A 204
GLY A 206
GLY A 215
ASP A 252
ASP A 275
 SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
None
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.92A 3ihtA-3ssmA:
10.8		 3ihtA-3ssmA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLU A  45
VAL A  98
GLY A 156
ARG A 194
ILE A  46
 None
 1.10A 3k13A-3ssmA:
undetectable		 3k13A-3ssmA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 SER A 239
ASP A 242
ARG A 219
ASP A 275
THR A 248
 None
None
None
MG  A 501 ( 2.8A)
None
 1.43A 3lpsA-3ssmA:
undetectable		 3lpsA-3ssmA:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 8 ALA A 145
ASP A  56
GLY A 140
ILE A 139
 None
 0.77A 3nu9A-3ssmA:
undetectable		 3nu9A-3ssmA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 10 ALA A 145
ASP A  56
GLY A 140
ILE A 139
VAL A  59
 None
 0.93A 3t3cB-3ssmA:
undetectable		 3t3cB-3ssmA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 7 PHE A 291
PHE A 287
ALA A 336
LEU A 329
 None
 0.87A 4ejgC-3ssmA:
undetectable		 4ejgC-3ssmA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 6 GLY A 214
ASP A 275
PRO A 174
HIS A 180
 None
MG  A 501 ( 2.8A)
SAH  A 601 (-4.8A)
MG  A 501 ( 4.5A)
 0.96A 4lajA-3ssmA:
undetectable
4lajB-3ssmA:
undetectable		 4lajA-3ssmA:
19.25
4lajB-3ssmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 6 GLY A 215
ASP A 275
PRO A 174
HIS A 180
 None
MG  A 501 ( 2.8A)
SAH  A 601 (-4.8A)
MG  A 501 ( 4.5A)
 1.22A 4lajA-3ssmA:
undetectable
4lajB-3ssmA:
undetectable		 4lajA-3ssmA:
19.25
4lajB-3ssmA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 5 ASN A  55
PRO A  53
GLY A 149
ASP A 163
 None
 1.09A 4n48B-3ssmA:
9.9		 4n48B-3ssmA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 5 ILE A 271
VAL A 200
PHE A 110
HIS A 189
 None
 1.16A 4rzvA-3ssmA:
undetectable		 4rzvA-3ssmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		4 / 7 GLY A 204
GLY A 206
ASP A 252
ASP A 275
 SAH  A 601 (-3.5A)
SAH  A 601 (-3.2A)
SAH  A 601 (-3.6A)
MG  A 501 ( 2.8A)
 0.64A 5ergB-3ssmA:
10.5		 5ergB-3ssmA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 THR A 173
SER A 217
ASP A 234
 SAH  A 601 (-4.0A)
SAH  A 601 (-3.2A)
SAH  A 601 (-2.8A)
 0.56A 5kvaA-3ssmA:
13.2		 5kvaA-3ssmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		3 / 3 THR A 173
SER A 217
ASP A 234
 SAH  A 601 (-4.0A)
SAH  A 601 (-3.2A)
SAH  A 601 (-2.8A)
 0.55A 5kvaB-3ssmA:
13.0		 5kvaB-3ssmA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLY A 215
GLY A 206
ASP A 242
ILE A 246
LEU A 218
 None
SAH  A 601 (-3.2A)
None
None
None
 0.99A 6b3aA-3ssmA:
8.1		 6b3aA-3ssmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLY A 215
GLY A 206
ASP A 242
ILE A 246
LEU A 218
 None
SAH  A 601 (-3.2A)
None
None
None
 0.96A 6b3bA-3ssmA:
8.0		 6b3bA-3ssmA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ssm METHYLTRANSFERASE
(Micromonospora
griseorubida) 		5 / 12 GLY A 251
GLN A 250
HIS A 240
LEU A 218
ILE A 203
 None
 1.44A 6md4A-3ssmA:
undetectable		 6md4A-3ssmA:
12.53