SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3stb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
(Trypanosoma
brucei) 		3 / 3 GLN D 119
ILE D 118
TYR D 117
 None
 0.66A 1vifA-3stbD:
undetectable		 1vifA-3stbD:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
(Lama
glama;
Trypanosoma
brucei) 		3 / 3 LYS A   4
ASP C 327
ASP C 331
 None
 1.13A 2br4A-3stbA:
undetectable		 2br4A-3stbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
(Lama
glama;
Trypanosoma
brucei) 		3 / 3 LYS A   4
GLY C 326
PRO C 325
 None
 0.86A 2hreB-3stbA:
undetectable		 2hreB-3stbA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		5 / 11 ALA A  35
ILE A  71
ILE A 110
ALA A  98
VAL A  80
 None
 1.16A 2qhfA-3stbA:
undetectable		 2qhfA-3stbA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei;
Trypanosoma
brucei) 		5 / 12 SER C 324
GLY C 326
ARG A  29
ILE A 110
TYR D 117
 None
 1.38A 3iizA-3stbC:
undetectable		 3iizA-3stbC:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3stb SINGLE DOMAIN
ANTIBODY VHH
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei) 		3 / 3 ARG A  73
ASP A 116
GLN D  46
 None
 0.82A 3lcvB-3stbA:
undetectable		 3lcvB-3stbA:
19.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  26
MET A  36
ARG A  73
ASN A  78
VAL A  80
ALA A  99
 None
 0.79A 3qxtA-3stbA:
22.2		 3qxtA-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		5 / 12 VAL A   4
ALA A  26
ARG A  73
ASN A  78
VAL A  80
 None
 1.00A 3qxtA-3stbA:
22.2		 3qxtA-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 LEU A   6
ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
 None
 0.52A 3qxtB-3stbA:
22.3		 3qxtB-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 VAL A   4
LEU A   6
ALA A  26
MET A  36
ARG A  73
VAL A  80
 None
 0.78A 3qxtB-3stbA:
22.3		 3qxtB-3stbA:
71.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 12 ALA A  26
MET A  36
ARG A  73
ASN A  75
VAL A  80
ALA A  99
 None
 0.68A 3qxvA-3stbA:
22.1		 3qxvA-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		5 / 12 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
 None
 0.67A 3qxvB-3stbA:
22.0		 3qxvB-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		6 / 11 ALA A  26
MET A  36
ARG A  73
ASN A  75
VAL A  80
ALA A  99
 None
 0.71A 3qxvC-3stbA:
22.5		 3qxvC-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		5 / 12 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
 None
 0.65A 3qxvD-3stbA:
22.0		 3qxvD-3stbA:
70.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		5 / 12 ALA A  26
MET A  36
ARG A  73
VAL A  80
ALA A  99
 None
 0.66A 3qxvE-3stbA:
18.4		 3qxvE-3stbA:
70.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei) 		3 / 3 LYS A   4
ARG A 101
LEU D 105
 None
 1.41A 3v4tE-3stbA:
undetectable		 3v4tE-3stbA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei;
Trypanosoma
brucei) 		5 / 12 SER C 324
GLY C 326
ARG A  29
ILE A 110
TYR D 117
 None
 1.39A 4jxcA-3stbC:
undetectable		 4jxcA-3stbC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei;
Trypanosoma
brucei) 		4 / 5 TYR D 117
GLN D 119
SER C 324
ASP A 116
 None
 1.47A 4qtuB-3stbD:
undetectable		 4qtuB-3stbD:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
(Trypanosoma
brucei) 		4 / 6 GLU D  77
GLY D  97
ARG D  98
GLY D 125
 None
 0.88A 5cdnA-3stbD:
undetectable
5cdnB-3stbD:
undetectable		 5cdnA-3stbD:
13.36
5cdnB-3stbD:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
(Trypanosoma
brucei) 		4 / 6 GLU D  77
GLY D  97
ARG D  98
GLY D 125
 None
 0.89A 5cdnR-3stbD:
undetectable
5cdnS-3stbD:
undetectable		 5cdnR-3stbD:
13.36
5cdnS-3stbD:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		4 / 7 ALA A  93
THR A  92
VAL A 124
GLU A  90
 None
 0.70A 5ecmD-3stbA:
undetectable		 5ecmD-3stbA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3stb SINGLE DOMAIN
ANTIBODY VHH
(Lama
glama) 		4 / 7 ALA A  93
THR A  92
VAL A 124
GLU A  90
 None
 0.79A 5ecoD-3stbA:
undetectable		 5ecoD-3stbA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3stb SINGLE DOMAIN
ANTIBODY VHH
RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN
(Lama
glama;
Trypanosoma
brucei;
Trypanosoma
brucei) 		5 / 12 SER C 324
GLY C 326
ARG A  29
ILE A 110
TYR D 117
 None
 1.38A 5fesA-3stbC:
undetectable		 5fesA-3stbC:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
(Trypanosoma
brucei) 		3 / 3 VAL D  95
GLN D  46
CYH D  74
 None
 0.72A 5icxC-3stbD:
undetectable
5icxF-3stbD:
undetectable		 5icxC-3stbD:
20.00
5icxF-3stbD:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
RNA-EDITING COMPLEX
PROTEIN MP42
(Trypanosoma
brucei) 		5 / 12 GLY D  97
ASP D  68
HIS D  70
ILE C 381
MET C 294
 None
 1.41A 5igwA-3stbD:
undetectable		 5igwA-3stbD:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3stb MP18 RNA EDITING
COMPLEX PROTEIN
RNA-EDITING COMPLEX
PROTEIN MP42
(Trypanosoma
brucei) 		5 / 12 LEU D  27
GLY D  97
LEU D 101
MET C 294
LEU C 362
 None
 1.11A 6f6iA-3stbD:
undetectable
6f6iB-3stbD:
undetectable		 6f6iA-3stbD:
20.86
6f6iB-3stbD:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 3stb RNA-EDITING COMPLEX
PROTEIN MP42
MP18 RNA EDITING
COMPLEX PROTEIN
(Trypanosoma
brucei;
Trypanosoma
brucei) 		5 / 12 ILE C 301
VAL C 335
THR C 334
PHE C 332
PRO D 103
 None
 1.17A 6hlpA-3stbC:
undetectable		 6hlpA-3stbC:
14.09