SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 ASN A 319
TYR A 323
ASN A 155
TYR A 317
 NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
None
None
 0.95A 1dssG-3sthA:
52.5		 1dssG-3sthA:
62.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		7 / 7 SER A 151
THR A 153
ASN A 155
CYH A 156
TYR A 317
ASN A 319
TYR A 323
 None
None
None
None
None
NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
 0.16A 1dssG-3sthA:
52.5		 1dssG-3sthA:
62.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 ASN A 319
TYR A 323
ASN A 155
TYR A 317
 NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
None
None
 0.94A 1dssR-3sthA:
52.5		 1dssR-3sthA:
62.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		8 / 8 SER A 151
THR A 153
ASN A 155
CYH A 156
HIS A 179
TYR A 317
ASN A 319
TYR A 323
 None
None
None
None
None
None
NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
 0.34A 1dssR-3sthA:
52.5		 1dssR-3sthA:
62.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 9 ILE A 170
VAL A 219
GLY A 220
ALA A 161
LEU A 157
 None
 0.99A 1e7bA-3sthA:
undetectable		 1e7bA-3sthA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 PHE A  10
VAL A  68
VAL A  75
ILE A  32
 None
 0.99A 1t87B-3sthA:
undetectable		 1t87B-3sthA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 LYS A 141
ASP A 338
THR A 128
PRO A 129
 None
None
None
EDO  A 701 (-4.9A)
 0.99A 1z2bB-3sthA:
3.1		 1z2bB-3sthA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ARG A 236
VAL A 245
THR A 153
 None
 0.85A 2nnkA-3sthA:
undetectable		 2nnkA-3sthA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ALA A  21
GLY A   6
TYR A  93
ILE A  84
ALA A  31
 None
 1.09A 2plwA-3sthA:
3.7		 2plwA-3sthA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 VAL A 135
SER A 296
SER A 315
VAL A 264
ALA A 267
 None
 1.27A 2x2iC-3sthA:
undetectable		 2x2iC-3sthA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 7 MET A 334
VAL A 147
ILE A 119
TYR A 140
 None
 1.13A 2yfbA-3sthA:
undetectable		 2yfbA-3sthA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 HIS A 291
ASP A 318
HIS A  52
ASP A 241
 None
 1.24A 3c0zA-3sthA:
undetectable		 3c0zA-3sthA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 VAL A  91
ALA A 115
ALA A 331
THR A  74
ILE A  84
 None
 1.30A 3dl9B-3sthA:
undetectable		 3dl9B-3sthA:
20.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 ASN A 319
TYR A 323
ASN A 155
TYR A 317
 NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
None
None
 0.96A 3dmtC-3sthA:
49.1		 3dmtC-3sthA:
48.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		8 / 8 SER A 151
THR A 153
ASN A 155
CYH A 156
HIS A 179
TYR A 317
ASN A 319
TYR A 323
 None
None
None
None
None
None
NAD  A 380 (-3.8A)
NAD  A 380 (-3.6A)
 0.28A 3dmtC-3sthA:
49.1		 3dmtC-3sthA:
48.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 4 LEU A 327
MET A  22
ILE A  84
ASP A  34
 None
None
None
NAD  A 380 (-2.7A)
 1.46A 3hecA-3sthA:
undetectable		 3hecA-3sthA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 ILE A  94
GLY A   6
ALA A  21
ALA A  89
VAL A  91
 None
 1.01A 3jb3A-3sthA:
undetectable		 3jb3A-3sthA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ARG A 236
VAL A 245
THR A 153
 None
 0.86A 3k4vA-3sthA:
undetectable		 3k4vA-3sthA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 VAL A  75
VAL A  91
ILE A  84
ARG A  15
 None
 1.10A 3ms9A-3sthA:
undetectable		 3ms9A-3sthA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 VAL A  75
VAL A  91
ILE A  84
ARG A  15
 None
 1.13A 3mssC-3sthA:
undetectable		 3mssC-3sthA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 ILE A 146
CYH A   3
LEU A   5
ILE A  94
 None
 0.89A 4asdA-3sthA:
undetectable		 4asdA-3sthA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		5 / 12 TYR A 317
ASN A 227
GLY A 214
ALA A 215
GLY A 220
 None
 0.96A 4e1gA-3sthA:
undetectable		 4e1gA-3sthA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ILE A 119
MET A 133
ARG A 326
 None
 0.91A 4lnwA-3sthA:
undetectable		 4lnwA-3sthA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 ILE A 119
MET A 133
ARG A 326
 None
 0.91A 4lnxA-3sthA:
undetectable		 4lnxA-3sthA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 PHE A  10
MET A  37
ILE A  32
VAL A  59
 None
 1.02A 4mk4B-3sthA:
2.9		 4mk4B-3sthA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		3 / 3 THR A 154
ALA A 150
ASN A 155
 None
 0.57A 5ersA-3sthA:
2.5		 5ersA-3sthA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 8 TYR A 323
SER A 151
THR A 153
PRO A 124
 NAD  A 380 (-3.6A)
None
None
None
 0.95A 5jhdE-3sthA:
undetectable
5jhdG-3sthA:
undetectable		 5jhdE-3sthA:
20.27
5jhdG-3sthA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 5 TYR A  93
LYS A 117
GLY A 339
SER A 335
 None
 1.39A 5jhdJ-3sthA:
undetectable		 5jhdJ-3sthA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3sth GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Toxoplasma
gondii) 		4 / 6 PHE A 235
VAL A 178
ALA A 234
THR A 153
 None
 1.06A 5t7bA-3sthA:
3.1		 5t7bA-3sthA:
17.69