SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 LEU A 116
GLY A  75
VAL A  68
ALA A 228
LEU A 231
 None
 1.12A 1gs4A-3stiA:
undetectable		 1gs4A-3stiA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.79A 1hshA-3stiA:
undetectable		 1hshA-3stiA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 9 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.82A 1hshB-3stiA:
undetectable		 1hshB-3stiA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 189
GLY A 145
ILE A 201
VAL A  68
 None
 0.84A 2oxtA-3stiA:
undetectable		 2oxtA-3stiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A 189
GLY A 145
ILE A 201
VAL A  68
 None
 0.87A 2oxtB-3stiA:
undetectable		 2oxtB-3stiA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 LEU A 191
GLY A 188
VAL A  68
ILE A 176
ALA A 218
 None
 1.18A 2yy8A-3stiA:
undetectable
2yy8B-3stiA:
undetectable		 2yy8A-3stiA:
21.92
2yy8B-3stiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 LEU A 191
GLY A 189
VAL A  68
ILE A 176
ALA A 218
 None
 0.89A 2yy8A-3stiA:
undetectable
2yy8B-3stiA:
undetectable		 2yy8A-3stiA:
21.92
2yy8B-3stiA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 9 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.87A 3s43A-3stiA:
undetectable		 3s43A-3stiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.83A 3s54A-3stiA:
undetectable		 3s54A-3stiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.75A 3s54B-3stiA:
undetectable		 3s54B-3stiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 ALA A 114
GLY A  65
ILE A 205
VAL A  77
LEU A 116
 None
 1.15A 3zosA-3stiA:
undetectable
3zosB-3stiA:
undetectable		 3zosA-3stiA:
21.88
3zosB-3stiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A  65
VAL A  29
ALA A 204
ASP A 112
 None
 1.02A 4a6dA-3stiA:
undetectable		 4a6dA-3stiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A  65
VAL A  29
ALA A 204
ASP A 112
 None
 1.04A 4a6eA-3stiA:
undetectable		 4a6eA-3stiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A  67
THR A 125
GLY A 145
VAL A 144
 None
 0.83A 4o33A-3stiA:
undetectable		 4o33A-3stiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		4 / 7 LEU A 191
ILE A  70
ILE A 127
VAL A  68
 None
 0.75A 4ojbA-3stiA:
undetectable		 4ojbA-3stiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 ALA A  25
VAL A 144
GLY A 189
ILE A 129
ILE A 127
 None
 0.74A 5e5jA-3stiA:
undetectable		 5e5jA-3stiA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3sti PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 149
GLY A  75
VAL A  77
ILE A 118
GLY A  97
 None
 0.87A 5koxA-3stiA:
undetectable		 5koxA-3stiA:
20.68