SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3stj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 VAL A  26
LEU A 192
GLY A 145
SER A 156
MET A  18
 None
 1.41A 1fdsA-3stjA:
undetectable		 1fdsA-3stjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 VAL A 267
GLY A 284
GLY A 246
SER A 250
VAL A 261
 None
 1.09A 1fduA-3stjA:
undetectable		 1fduA-3stjA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 7 THR A 203
LEU A 191
GLY A 189
LEU A  78
 None
 0.96A 1gtiD-3stjA:
undetectable		 1gtiD-3stjA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 9 VAL A  68
ILE A 201
GLY A 200
ILE A 199
ILE A 127
 None
 1.03A 1hpvA-3stjA:
undetectable		 1hpvA-3stjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 6 PRO A  60
GLN A  88
LYS A  89
VAL A  31
 None
 1.24A 1l2iB-3stjA:
undetectable		 1l2iB-3stjA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		3 / 3 ASN A 202
ILE A 113
MET A 223
 None
 0.79A 2h42C-3stjA:
undetectable		 2h42C-3stjA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 LEU A 227
THR A 308
ILE A 237
LEU A 316
VAL A 314
 None
 1.21A 2n27A-3stjA:
undetectable		 2n27A-3stjA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		6 / 12 ILE A 182
GLY A 185
SER A  66
ALA A 190
ALA A 143
VAL A 142
 None
 1.44A 2oc8A-3stjA:
13.9		 2oc8A-3stjA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 HIS A  82
LEU A 191
GLY A 189
VAL A  68
ALA A 218
 None
 1.14A 2yy8A-3stjA:
undetectable
2yy8B-3stjA:
undetectable		 2yy8A-3stjA:
22.22
2yy8B-3stjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 LEU A 191
GLY A 189
VAL A  26
ILE A 176
ALA A 218
 None
 1.01A 2yy8A-3stjA:
undetectable
2yy8B-3stjA:
undetectable		 2yy8A-3stjA:
22.22
2yy8B-3stjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 LEU A 191
GLY A 189
VAL A  68
ILE A 176
ALA A 218
 None
 0.94A 2yy8A-3stjA:
undetectable
2yy8B-3stjA:
undetectable		 2yy8A-3stjA:
22.22
2yy8B-3stjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 8 VAL A 327
ILE A 244
VAL A 270
GLY A 280
 None
 0.89A 3hjoB-3stjA:
undetectable		 3hjoB-3stjA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.71A 3keeA-3stjA:
14.4		 3keeA-3stjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.66A 3keeB-3stjA:
14.2		 3keeB-3stjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.68A 3keeC-3stjA:
13.9		 3keeC-3stjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.67A 3keeD-3stjA:
14.5		 3keeD-3stjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 10 VAL A  29
GLY A  67
GLN A  86
ILE A 201
GLY A  65
 None
 1.25A 3km6A-3stjA:
undetectable		 3km6A-3stjA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 ALA A 102
VAL A  29
ILE A  84
VAL A  27
ILE A  92
 None
 1.01A 3lzvB-3stjA:
undetectable		 3lzvB-3stjA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 9 VAL A  29
SER A  28
ILE A 118
ALA A 102
ALA A 114
 None
 1.32A 3mdtA-3stjA:
undetectable		 3mdtA-3stjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 10 ALA A 102
VAL A  29
ILE A  84
VAL A  27
ILE A  92
 None
 1.00A 3nujA-3stjA:
undetectable		 3nujA-3stjA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.68A 3sueA-3stjA:
9.4		 3sueA-3stjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.68A 3sueC-3stjA:
9.3		 3sueC-3stjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.70A 3sueD-3stjA:
4.3		 3sueD-3stjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.71A 3sufA-3stjA:
13.2		 3sufA-3stjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 11 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.69A 3sufC-3stjA:
9.2		 3sufC-3stjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.68A 3sufD-3stjA:
13.2		 3sufD-3stjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 5 ILE A 244
VAL A 327
LEU A 325
ASP A 285
 None
 0.99A 3wzdA-3stjA:
undetectable		 3wzdA-3stjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A  67
THR A 125
GLY A 145
VAL A 144
 None
 0.82A 4o33A-3stjA:
undetectable		 4o33A-3stjA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 GLY A 188
GLY A  67
THR A 125
GLY A 145
VAL A 144
 None
 0.87A 4o3fA-3stjA:
undetectable		 4o3fA-3stjA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 9 ALA A 143
SER A 132
GLY A 200
ALA A 218
VAL A 159
 None
 1.20A 4r1zA-3stjA:
undetectable		 4r1zA-3stjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 SER A 160
THR A 155
ALA A 143
ALA A 141
ASN A 202
 None
 1.20A 4u15B-3stjA:
undetectable		 4u15B-3stjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 LEU A 295
ILE A 286
GLY A 246
LEU A 242
THR A 307
 None
 1.13A 4ze2A-3stjA:
undetectable		 4ze2A-3stjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 5 PRO A 310
GLY A 311
THR A 312
LYS A 313
 None
 1.14A 5x23A-3stjA:
undetectable		 5x23A-3stjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 6 PRO A 310
GLY A 311
THR A 312
LYS A 313
 None
 1.09A 5xxiA-3stjA:
undetectable		 5xxiA-3stjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		5 / 12 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.62A 6c2mC-3stjA:
13.2		 6c2mC-3stjA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3stj PROTEASE DEGQ
(Escherichia
coli) 		4 / 7 LEU A 301
VAL A 329
LEU A 316
LEU A 318
 None
 0.66A 6g9bA-3stjA:
undetectable
6g9bB-3stjA:
undetectable		 6g9bA-3stjA:
16.23
6g9bB-3stjA:
13.94