SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sto'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		5 / 12 LEU A 318
THR A 119
ILE A 121
ILE A  52
THR A  70
 None
 1.13A 1re7A-3stoA:
undetectable		 1re7A-3stoA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 ILE A  46
VAL A 256
ILE A 382
ILE A 243
 None
 0.82A 1uwhA-3stoA:
undetectable		 1uwhA-3stoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.98A 1v54A-3stoA:
undetectable
1v54J-3stoA:
undetectable		 1v54A-3stoA:
20.56
1v54J-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.95A 1v55A-3stoA:
undetectable
1v55J-3stoA:
undetectable		 1v55A-3stoA:
20.56
1v55J-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 8 GLY A  45
PHE A 253
THR A 101
ASN A  97
 None
 1.07A 2a8tB-3stoA:
undetectable		 2a8tB-3stoA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.97A 2dyrA-3stoA:
undetectable
2dyrJ-3stoA:
undetectable		 2dyrA-3stoA:
20.56
2dyrJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.98A 2dysA-3stoA:
undetectable
2dysJ-3stoA:
undetectable		 2dysA-3stoA:
20.56
2dysJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 1.00A 2dysN-3stoA:
undetectable
2dysW-3stoA:
undetectable		 2dysN-3stoA:
20.56
2dysW-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.98A 2eijA-3stoA:
undetectable
2eijJ-3stoA:
undetectable		 2eijA-3stoA:
20.56
2eijJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.96A 2eikA-3stoA:
undetectable
2eikJ-3stoA:
undetectable		 2eikA-3stoA:
20.56
2eikJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.93A 2eilA-3stoA:
undetectable
2eilJ-3stoA:
undetectable		 2eilA-3stoA:
20.56
2eilJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		5 / 12 LEU A  53
LEU A 318
ILE A 137
SER A 324
VAL A 123
 None
 1.17A 2hrcA-3stoA:
undetectable		 2hrcA-3stoA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 5 LEU A 335
LEU A 326
LEU A  54
MET A 186
 None
 1.13A 2oaxF-3stoA:
undetectable		 2oaxF-3stoA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 1.00A 2zxwA-3stoA:
undetectable
2zxwJ-3stoA:
undetectable		 2zxwA-3stoA:
20.56
2zxwJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		5 / 12 THR A  31
LEU A  27
ASN A 302
ILE A 382
PRO A 393
 None
 1.14A 3a51C-3stoA:
undetectable		 3a51C-3stoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.98A 3abmA-3stoA:
undetectable
3abmJ-3stoA:
undetectable		 3abmA-3stoA:
20.56
3abmJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.97A 3ag3A-3stoA:
undetectable
3ag3J-3stoA:
undetectable		 3ag3A-3stoA:
20.56
3ag3J-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.99A 3asnA-3stoA:
undetectable
3asnJ-3stoA:
undetectable		 3asnA-3stoA:
20.56
3asnJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.97A 3asoA-3stoA:
undetectable
3asoJ-3stoA:
undetectable		 3asoA-3stoA:
20.56
3asoJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 THR A  49
GLY A  51
ILE A  67
LEU A  47
 None
 0.78A 4ac9C-3stoA:
undetectable		 4ac9C-3stoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 THR A  49
GLY A  51
ILE A  67
LEU A  47
 None
 0.77A 4acaC-3stoA:
undetectable		 4acaC-3stoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 THR A  49
GLY A  51
ILE A  67
LEU A  47
 None
 0.82A 4acbC-3stoA:
undetectable		 4acbC-3stoA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 4 LEU A  27
ILE A 382
GLY A 275
PHE A 384
 None
 1.05A 4dc3A-3stoA:
undetectable		 4dc3A-3stoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_D_SAMD401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		5 / 11 GLY A  45
ASN A 190
ASN A  97
TYR A  93
GLU A  95
 None
 1.35A 4jdsD-3stoA:
0.6		 4jdsD-3stoA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 8 LEU A 335
SER A  56
VAL A 189
GLY A 120
 None
 1.01A 4klrB-3stoA:
undetectable		 4klrB-3stoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 PRO A 371
GLU A 372
TRP A 198
THR A 251
 None
 1.30A 4uacA-3stoA:
undetectable		 4uacA-3stoA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.97A 5b1aA-3stoA:
undetectable
5b1aJ-3stoA:
undetectable		 5b1aA-3stoA:
20.56
5b1aJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.97A 5b3sA-3stoA:
undetectable
5b3sJ-3stoA:
undetectable		 5b3sA-3stoA:
20.56
5b3sJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 1.03A 5x1fA-3stoA:
undetectable
5x1fJ-3stoA:
undetectable		 5x1fA-3stoA:
20.56
5x1fJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.98A 5xdxA-3stoA:
undetectable
5xdxJ-3stoA:
undetectable		 5xdxA-3stoA:
20.56
5xdxJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 5 VAL A 256
THR A 254
LEU A 272
LEU A  27
 None
 1.02A 6bqgA-3stoA:
undetectable		 6bqgA-3stoA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 GLY A  45
LEU A  44
PHE A  39
PHE A  34
 None
 0.88A 6h7lA-3stoA:
undetectable		 6h7lA-3stoA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 6 GLY A  45
LEU A  44
PHE A  39
PHE A  34
 None
 0.88A 6h7lB-3stoA:
undetectable		 6h7lB-3stoA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		3 / 3 ILE A 220
THR A 221
PRO A 402
 None
 0.57A 6ncsA-3stoA:
undetectable		 6ncsA-3stoA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sto SERINE PROTEASE
INHIBITOR
(Schistosoma
haematobium) 		4 / 7 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.93A 6nmfA-3stoA:
undetectable
6nmfJ-3stoA:
undetectable		 6nmfA-3stoA:
20.56
6nmfJ-3stoA:
9.14