SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		4 / 8 CYH A  45
ASP A  24
CYH A  22
GLY A  26
 ZN  A 161 (-2.2A)
None
ZN  A 161 (-2.3A)
None
 0.96A 1ekjA-3subA:
undetectable
1ekjB-3subA:
undetectable		 1ekjA-3subA:
22.87
1ekjB-3subA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		3 / 3 LYS A 100
ASP A  31
ASP A  24
 None
 1.02A 2br4D-3subA:
undetectable		 2br4D-3subA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		4 / 8 HIS A  37
SER A  34
ASN A  36
ILE A  58
 None
 1.09A 2v57A-3subA:
undetectable		 2v57A-3subA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		4 / 8 HIS A  37
SER A  34
ASN A  36
ILE A  58
 None
 1.09A 2v57C-3subA:
undetectable		 2v57C-3subA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		4 / 7 ASP A  24
HIS A  49
LEU A  87
ILE A 135
 None
 0.87A 3avpA-3subA:
undetectable		 3avpA-3subA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)		 3sub ADP-RIBOSYLATION
FACTOR
GTPASE-ACTIVATING
PROTEIN
(Plasmodium
falciparum) 		5 / 12 TYR A 101
VAL A  35
SER A  34
CYH A  83
VAL A 117
 None
 1.48A 4rujA-3subA:
undetectable		 4rujA-3subA:
20.79