SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 10 PHE A 146
ALA A 336
LEU A 298
VAL A 300
ILE A 334
 None
 1.33A 1claA-3sunA:
undetectable		 1claA-3sunA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 LEU A 605
MET A 408
MET A 683
LEU A 651
 None
 0.95A 1kt3A-3sunA:
undetectable		 1kt3A-3sunA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 12 TYR A 619
ASP A 621
TYR A 626
GLU A 716
TRP A 702
 None
None
None
CA  A 900 (-4.6A)
None
 1.04A 1maaA-3sunA:
undetectable		 1maaA-3sunA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 ASN A 676
PHE A 589
SER A 418
ARG A 421
 None
 1.44A 1rqpB-3sunA:
undetectable		 1rqpB-3sunA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 PHE A 280
ASN A 558
PHE A 282
SER A 565
 None
 1.15A 1rqpB-3sunA:
undetectable		 1rqpB-3sunA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 PHE A 280
ASN A 558
PHE A 282
SER A 565
 None
 1.09A 1rqpA-3sunA:
undetectable		 1rqpA-3sunA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 TRP A 162
VAL A 148
THR A 137
ILE A 183
 None
 1.26A 1ss4A-3sunA:
undetectable		 1ss4A-3sunA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 TRP A 365
LEU A 561
LYS A 279
 None
 1.41A 1yajK-3sunA:
0.7		 1yajK-3sunA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 TYR A 619
ASP A 621
TYR A 626
TRP A 702
 None
 0.92A 2ha2A-3sunA:
undetectable		 2ha2A-3sunA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 TYR A 619
ASP A 621
TYR A 626
TRP A 702
 None
 0.90A 2ha2B-3sunA:
undetectable		 2ha2B-3sunA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 9 TYR A 619
ASP A 621
TYR A 626
GLU A 716
TRP A 702
 None
None
None
CA  A 900 (-4.6A)
None
 1.07A 2ha6A-3sunA:
0.2		 2ha6A-3sunA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 SER A 735
SER A 784
VAL A 782
LYS A 829
 None
 1.18A 2j9cA-3sunA:
3.4
2j9cB-3sunA:
3.6
2j9cC-3sunA:
2.9		 2j9cA-3sunA:
9.72
2j9cB-3sunA:
9.72
2j9cC-3sunA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 ALA A 780
ILE A 779
SER A 778
LYS A 859
 None
 1.08A 2othA-3sunA:
2.0		 2othA-3sunA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 PHE A 280
ASN A 558
PHE A 282
SER A 565
 None
 1.09A 2v7uA-3sunA:
undetectable		 2v7uA-3sunA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 ASN A 676
PHE A 589
SER A 418
ARG A 421
 None
 1.39A 2v7uB-3sunA:
undetectable		 2v7uB-3sunA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 PHE A 280
ASN A 558
PHE A 282
SER A 565
 None
 1.12A 2v7uB-3sunA:
undetectable		 2v7uB-3sunA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 VAL A 825
ASN A 217
TRP A 216
 None
 0.97A 2y00B-3sunA:
undetectable		 2y00B-3sunA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 PHE A 280
ASN A 558
PHE A 282
 None
 1.09A 2zbuD-3sunA:
2.1		 2zbuD-3sunA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMB_A_PXBA692_1
(LACTOTRANSFERRIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 PRO A 132
GLU A 314
TYR A 156
 None
 0.78A 2zmbA-3sunA:
undetectable		 2zmbA-3sunA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 PRO A 738
VAL A 741
THR A 703
GLY A 882
 None
 1.09A 3elzB-3sunA:
undetectable		 3elzB-3sunA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 10 LEU A 533
VAL A 516
ALA A 502
ILE A 499
PHE A 522
 None
 1.18A 3fl9A-3sunA:
undetectable		 3fl9A-3sunA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 10 LEU A 533
VAL A 516
ALA A 502
ILE A 499
PHE A 522
 None
 1.09A 3fl9F-3sunA:
undetectable		 3fl9F-3sunA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 4 ILE A 854
ARG A 813
ILE A 858
THR A 852
 None
 1.15A 3ia4C-3sunA:
undetectable		 3ia4C-3sunA:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 5 ASP A 411
LEU A 415
ARG A 482
LYS A 560
ASP A 623
 CA  A 897 (-2.4A)
TTP  A 896 (-4.3A)
TTP  A 896 (-2.9A)
TTP  A 896 (-2.8A)
CA  A 897 (-2.9A)
 0.67A 3kd5E-3sunA:
49.1		 3kd5E-3sunA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 GLN A 354
GLU A  26
GLU A   9
PRO A 244
 None
 1.22A 3ql6A-3sunA:
0.0		 3ql6A-3sunA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 LEU A 373
ARG A 384
ASN A 582
 None
 0.77A 3qxvD-3sunA:
undetectable		 3qxvD-3sunA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 ASP A  51
GLY A  54
PRO A 381
GLU A  81
 None
 0.78A 3s3mA-3sunA:
3.5		 3s3mA-3sunA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 ILE A 632
PHE A 654
MET A 659
PHE A 616
 None
 1.22A 3tvxB-3sunA:
undetectable		 3tvxB-3sunA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 TYR A 323
VAL A 178
SER A 322
GLY A 175
 None
 1.32A 3v4tA-3sunA:
undetectable
3v4tD-3sunA:
undetectable		 3v4tA-3sunA:
19.35
3v4tD-3sunA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 12 VAL A 211
SER A 269
LEU A 271
VAL A 358
PHE A 359
 None
 1.19A 3w68A-3sunA:
undetectable		 3w68A-3sunA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 GLU A 297
ILE A 334
PHE A 296
VAL A 782
 None
 1.19A 4a97I-3sunA:
3.4		 4a97I-3sunA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.91A 4dtzA-3sunA:
undetectable		 4dtzA-3sunA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.88A 4dtzB-3sunA:
undetectable		 4dtzB-3sunA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.88A 4du2A-3sunA:
undetectable		 4du2A-3sunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 PHE A 701
ALA A 709
LEU A 730
THR A 732
 None
 0.89A 4du2B-3sunA:
undetectable		 4du2B-3sunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 ILE A 425
GLY A 393
ALA A 567
GLN A 595
 None
 0.95A 4g0uB-3sunA:
4.1		 4g0uB-3sunA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 ILE A 186
GLU A 116
VAL A 178
PRO A 179
 None
CA  A 901 (-2.6A)
None
None
 0.61A 4jltA-3sunA:
undetectable		 4jltA-3sunA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 CYH A 609
ASN A 606
LYS A 631
 None
 1.29A 4k50A-3sunA:
undetectable		 4k50A-3sunA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 12 ILE A 230
ILE A 115
LEU A 213
VAL A 270
LEU A 265
 None
 1.10A 4km2A-3sunA:
undetectable		 4km2A-3sunA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 9 VAL A 110
ILE A 212
LEU A 271
ILE A 108
GLY A 348
 None
 1.07A 4kukA-3sunA:
undetectable		 4kukA-3sunA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 ASN A 228
GLU A 125
GLU A 261
TYR A 257
 None
 0.90A 4mj8A-3sunA:
undetectable
4mj8C-3sunA:
undetectable		 4mj8A-3sunA:
12.38
4mj8C-3sunA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 8 ILE A 530
ILE A 499
ASN A 495
ALA A 545
 None
 0.91A 4ou1A-3sunA:
undetectable		 4ou1A-3sunA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 LEU A 725
LEU A 730
ILE A 698
PHE A 701
 None
 1.25A 4y4dA-3sunA:
undetectable		 4y4dA-3sunA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 LYS A 279
TYR A 277
TYR A 273
LEU A 271
 None
 1.22A 4yv5B-3sunA:
1.9		 4yv5B-3sunA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 7 TRP A 848
THR A 852
PRO A 849
SER A 287
 None
 1.19A 5b6iA-3sunA:
undetectable		 5b6iA-3sunA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 5 PHE A 701
ILE A 727
GLY A 700
ILE A 749
LEU A 710
 None
 1.46A 5dzkB-3sunA:
undetectable
5dzkI-3sunA:
undetectable
5dzkW-3sunA:
undetectable		 5dzkB-3sunA:
13.39
5dzkI-3sunA:
13.16
5dzkW-3sunA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 5 PHE A 701
ILE A 727
GLY A 700
ILE A 749
LEU A 710
 None
 1.43A 5dzkd-3sunA:
undetectable
5dzkk-3sunA:
undetectable
5dzky-3sunA:
undetectable		 5dzkd-3sunA:
13.39
5dzkk-3sunA:
13.16
5dzky-3sunA:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 TYR A 619
ASP A 621
TYR A 626
TRP A 702
 None
 0.95A 5e2iA-3sunA:
undetectable		 5e2iA-3sunA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 TYR A 577
GLY A 469
GLU A 428
ILE A  52
ASP A  51
 None
 1.36A 5hjiA-3sunA:
undetectable		 5hjiA-3sunA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 LYS A 560
ARG A 482
ASP A 623
ASP A 411
 TTP  A 896 (-2.8A)
TTP  A 896 (-2.9A)
CA  A 897 (-2.9A)
CA  A 897 (-2.4A)
 1.30A 5hp1C-3sunA:
3.0		 5hp1C-3sunA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 10 GLY A  79
ALA A  39
GLU A  81
ASP A  77
ILE A  78
 None
 1.21A 5i3cB-3sunA:
undetectable		 5i3cB-3sunA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 TYR A 201
ASP A 140
HIS A 138
ILE A 187
 None
 1.20A 5ih0A-3sunA:
undetectable		 5ih0A-3sunA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 PHE A 654
ILE A 632
MET A 659
ARG A 658
 None
 1.23A 5jm4A-3sunA:
4.8		 5jm4A-3sunA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 5 ILE A 101
LYS A 107
ILE A 108
HIS A 105
 None
 0.93A 5jmnA-3sunA:
4.4		 5jmnA-3sunA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 12 ILE A 355
ALA A 111
SER A 141
VAL A 211
ILE A 212
 None
 1.23A 5mlmA-3sunA:
undetectable		 5mlmA-3sunA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		4 / 6 ARG A 249
PHE A 266
ILE A 263
THR A 264
 None
 1.11A 5vceA-3sunA:
undetectable		 5vceA-3sunA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 TYR A 349
LEU A  93
ASP A  87
 None
 0.69A 5zv2B-3sunA:
undetectable		 5zv2B-3sunA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 SER A 537
LYS A 536
SER A 534
 None
 0.67A 6az3P-3sunA:
undetectable		 6az3P-3sunA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 12 LEU A  83
VAL A 471
ARG A 576
ILE A 369
ASP A 366
 None
 1.43A 6bxnA-3sunA:
undetectable		 6bxnA-3sunA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 10 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.07A 6ebpD-3sunA:
undetectable		 6ebpD-3sunA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.04A 6ebzA-3sunA:
undetectable		 6ebzA-3sunA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.06A 6ebzB-3sunA:
undetectable		 6ebzB-3sunA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.07A 6ebzD-3sunA:
undetectable		 6ebzD-3sunA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 THR A 644
GLU A 638
SER A 695
LEU A 725
ALA A 709
 None
 1.47A 6efnA-3sunA:
undetectable		 6efnA-3sunA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		3 / 3 ASP A 714
ASP A 411
ASN A 564
 None
CA  A 897 (-2.4A)
TTP  A 896 (-3.2A)
 0.79A 6gngB-3sunA:
undetectable		 6gngB-3sunA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.04A 6gp2A-3sunA:
undetectable		 6gp2A-3sunA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3sun DNA POLYMERASE
(Escherichia
virus
RB69) 		5 / 11 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
 None
 1.06A 6gp2B-3sunA:
undetectable		 6gp2B-3sunA:
7.10