SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 6 LEU A  60
ILE A 153
TRP A 467
VAL A 110
 None
 1.13A 1db1A-3sutA:
undetectable		 1db1A-3sutA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 11 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.03A 1dhiB-3sutA:
undetectable		 1dhiB-3sutA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.03A 1draB-3sutA:
undetectable		 1draB-3sutA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 8 VAL A 350
GLY A 351
TYR A 434
GLU A 437
 None
 1.02A 1jlfA-3sutA:
undetectable
1jlfB-3sutA:
undetectable		 1jlfA-3sutA:
22.15
1jlfB-3sutA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 ASN A 343
PHE A 335
VAL A 349
 None
 0.80A 1kijA-3sutA:
undetectable		 1kijA-3sutA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.07A 1ra3A-3sutA:
undetectable		 1ra3A-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.00A 1rb2A-3sutA:
undetectable		 1rb2A-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 0.93A 1rb2B-3sutA:
undetectable		 1rb2B-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 0.98A 1rb3B-3sutA:
undetectable		 1rb3B-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.01A 1rd7A-3sutA:
undetectable		 1rd7A-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.05A 1re7B-3sutA:
undetectable		 1re7B-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.03A 1rx2A-3sutA:
undetectable		 1rx2A-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 GLY A 360
ASP A 332
TYR A 331
PRO A 256
 None
 0.88A 1th6A-3sutA:
undetectable		 1th6A-3sutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 PRO A 117
GLY A  44
ASN A  46
GLY A  48
 None
 0.82A 1zlqA-3sutA:
undetectable		 1zlqA-3sutA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 11 TRP A 210
VAL A 303
ILE A 253
LEU A 269
LEU A 289
 None
 1.23A 2a15A-3sutA:
undetectable		 2a15A-3sutA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 GLY A 360
ASP A 332
TYR A 331
PRO A 256
 None
 0.88A 2armA-3sutA:
undetectable		 2armA-3sutA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.04A 2drcB-3sutA:
undetectable		 2drcB-3sutA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 6 LEU A 459
ILE A 190
ILE A  56
LEU A 128
 None
 0.95A 2xkwB-3sutA:
undetectable		 2xkwB-3sutA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 10 ILE A 501
GLY A -10
SER A -11
VAL A  -8
TRP A 475
 None
 1.27A 2yk1H-3sutA:
undetectable
2yk1L-3sutA:
undetectable		 2yk1H-3sutA:
20.00
2yk1L-3sutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 SER A 186
GLU A 244
ASP A 183
 None
 0.77A 2zthA-3sutA:
undetectable		 2zthA-3sutA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.96A 3ag3A-3sutA:
undetectable
3ag3J-3sutA:
undetectable		 3ag3A-3sutA:
23.64
3ag3J-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 HIS A 196
ASP A 254
HIS A 258
ASP A 321
 None
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
 1.19A 3c0zA-3sutA:
undetectable		 3c0zA-3sutA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 GLY A 319
SER A 323
THR A 326
VAL A 338
ASP A 254
 None
 1.25A 3d91B-3sutA:
undetectable		 3d91B-3sutA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.02A 3drcB-3sutA:
undetectable		 3drcB-3sutA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 GLY A 123
ASP A 155
ILE A 153
GLN A 129
 None
 0.81A 3fi0P-3sutA:
undetectable		 3fi0P-3sutA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 10 THR A 357
SER A 358
VAL A 349
SER A 355
GLY A 351
 None
 1.32A 3ixlA-3sutA:
undetectable		 3ixlA-3sutA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 GLU A 244
ASP A 237
ASP A 183
 None
 0.76A 3jb2A-3sutA:
undetectable		 3jb2A-3sutA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		11 / 12 ARG A 170
HIS A 196
ASP A 199
ASP A 254
HIS A 258
ASP A 321
TRP A 370
TYR A 395
ASP A 397
TRP A 441
GLU A 443
 OAN  A2000 (-2.8A)
None
OAN  A2000 ( 4.4A)
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
OAN  A2000 (-3.4A)
OAN  A2000 (-4.4A)
OAN  A2000 (-3.1A)
OAN  A2000 (-3.7A)
OAN  A2000 (-2.6A)
 0.33A 3lmyA-3sutA:
38.0		 3lmyA-3sutA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		12 / 12 ARG A 170
HIS A 196
ASP A 199
ASP A 254
HIS A 258
ASP A 321
GLU A 322
TRP A 352
TRP A 370
TYR A 395
TRP A 441
GLU A 443
 OAN  A2000 (-2.8A)
None
OAN  A2000 ( 4.4A)
None
OAN  A2000 (-4.0A)
OAN  A2000 (-4.0A)
OAN  A2000 (-3.0A)
OAN  A2000 ( 3.9A)
OAN  A2000 (-3.4A)
OAN  A2000 (-4.4A)
OAN  A2000 (-3.7A)
OAN  A2000 (-2.6A)
 0.39A 3lmyB-3sutA:
38.1		 3lmyB-3sutA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 286
GLY A 257
ASN A 324
GLU A 252
LEU A 263
 None
 1.18A 4azsA-3sutA:
undetectable		 4azsA-3sutA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 286
GLY A 257
ASN A 324
GLU A 252
LEU A 263
 None
 1.25A 4azwA-3sutA:
undetectable		 4azwA-3sutA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
GLY A 257
GLY A 285
LEU A 318
GLY A 351
 OAN  A2000 (-4.0A)
None
None
None
None
 1.23A 4blvB-3sutA:
undetectable		 4blvB-3sutA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 TYR A 101
THR A 126
GLU A  99
 None
 0.70A 4df3A-3sutA:
undetectable		 4df3A-3sutA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 TYR A 101
THR A 126
GLU A  99
 None
 0.70A 4df3B-3sutA:
undetectable		 4df3B-3sutA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.02A 4dfrB-3sutA:
undetectable		 4dfrB-3sutA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.00A 4ej1A-3sutA:
undetectable		 4ej1A-3sutA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 161
TYR A 456
LEU A 482
LEU A 489
LEU A 396
 None
 1.28A 4j03A-3sutA:
undetectable		 4j03A-3sutA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_A_LYAA304_1
(FOLATE RECEPTOR BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
SER A 313
HIS A 194
GLY A 163
TRP A 352
 OAN  A2000 (-4.0A)
None
None
None
OAN  A2000 ( 3.9A)
 1.43A 4kn2A-3sutA:
undetectable		 4kn2A-3sutA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_1
(FOLATE RECEPTOR BETA)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ASP A 321
SER A 313
HIS A 194
GLY A 163
TRP A 352
 OAN  A2000 (-4.0A)
None
None
None
OAN  A2000 ( 3.9A)
 1.42A 4kn2C-3sutA:
undetectable		 4kn2C-3sutA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A 247
ARG A 245
ILE A 190
ALA A 185
 None
 0.89A 4lv9A-3sutA:
4.6		 4lv9A-3sutA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		3 / 3 SER A 365
MET A 385
ASP A 321
 None
None
OAN  A2000 (-4.0A)
 0.96A 4mm4B-3sutA:
undetectable		 4mm4B-3sutA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.05A 4p3rA-3sutA:
undetectable		 4p3rA-3sutA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 11 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.03A 4p66A-3sutA:
undetectable		 4p66A-3sutA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 SER A 287
ASP A 254
GLY A 320
THR A 259
ASP A 356
 None
 1.29A 4pghB-3sutA:
undetectable		 4pghB-3sutA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A 153
SER A 154
ALA A  94
ALA A  95
ASN A 115
 None
 1.30A 4u14A-3sutA:
undetectable		 4u14A-3sutA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.04A 4x5gB-3sutA:
undetectable		 4x5gB-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 VAL A 178
TYR A 400
ILE A 501
THR A 486
 None
 1.32A 4ze1A-3sutA:
undetectable		 4ze1A-3sutA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.92A 5b1aA-3sutA:
undetectable
5b1aJ-3sutA:
undetectable		 5b1aA-3sutA:
23.64
5b1aJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.94A 5b3sA-3sutA:
undetectable
5b3sJ-3sutA:
undetectable		 5b3sA-3sutA:
23.64
5b3sJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 THR A  89
ALA A 114
ILE A  40
GLY A  57
LEU A  53
 None
 1.06A 5gs4A-3sutA:
undetectable		 5gs4A-3sutA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 8 HIS A 485
GLN A 129
LEU A 482
LEU A 460
 None
 1.10A 5hs6A-3sutA:
undetectable		 5hs6A-3sutA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 161
GLY A 435
VAL A 387
VAL A 366
ALA A 394
 None
 1.19A 5n0oA-3sutA:
undetectable		 5n0oA-3sutA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 161
GLY A 435
VAL A 387
VAL A 366
ALA A 394
 None
 1.19A 5n0rA-3sutA:
undetectable		 5n0rA-3sutA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 161
GLY A 435
VAL A 387
VAL A 366
ALA A 394
 None
 1.22A 5n0wA-3sutA:
undetectable		 5n0wA-3sutA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 9 TYR A 333
ASP A 332
GLY A 360
GLY A 336
ALA A 340
 None
 1.45A 5v3cA-3sutA:
5.8		 5v3cA-3sutA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 MET A 454
PHE A 445
SER A 404
ILE A 406
GLU A 443
 None
None
None
None
OAN  A2000 (-2.6A)
 1.05A 5w8aA-3sutA:
undetectable		 5w8aA-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 TYR A 400
MET A 454
PHE A 445
ILE A 406
GLU A 443
 None
None
None
None
OAN  A2000 (-2.6A)
 1.44A 5w8aA-3sutA:
undetectable		 5w8aA-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.89A 5xdqA-3sutA:
undetectable
5xdqJ-3sutA:
undetectable		 5xdqA-3sutA:
23.64
5xdqJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.91A 5xdqN-3sutA:
undetectable
5xdqW-3sutA:
undetectable		 5xdqN-3sutA:
23.64
5xdqW-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.93A 5xdxA-3sutA:
undetectable
5xdxJ-3sutA:
undetectable		 5xdxA-3sutA:
23.64
5xdxJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 11 ILE A  40
ALA A  59
LEU A 128
LEU A  34
ILE A  72
 None
 1.03A 5z6mA-3sutA:
undetectable		 5z6mA-3sutA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 8 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.94A 5zcoA-3sutA:
undetectable
5zcoJ-3sutA:
undetectable		 5zcoA-3sutA:
23.64
5zcoJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.92A 5zcpA-3sutA:
undetectable
5zcpJ-3sutA:
undetectable		 5zcpA-3sutA:
23.64
5zcpJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 7 ILE A  40
LEU A  60
THR A  35
LEU A  34
 None
 0.92A 5zcqA-3sutA:
undetectable
5zcqJ-3sutA:
undetectable		 5zcqA-3sutA:
23.64
5zcqJ-3sutA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 8 GLY A 407
ILE A 406
LYS A 399
ASP A 403
 None
 0.91A 6ag0A-3sutA:
9.7		 6ag0A-3sutA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		5 / 12 ILE A  40
LEU A  53
VAL A 120
LEU A  64
LEU A 131
 None
 1.18A 6b54A-3sutA:
undetectable		 6b54A-3sutA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EP4_A_DMEA601_1
(CHOLINESTERASE)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 5 TRP A 352
TYR A 395
TYR A 331
HIS A 258
 OAN  A2000 ( 3.9A)
OAN  A2000 (-4.4A)
None
OAN  A2000 (-4.0A)
 1.16A 6ep4A-3sutA:
undetectable		 6ep4A-3sutA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)		 3sut BETA-HEXOSAMINIDASE
(Paenibacillus
sp.
TS12) 		4 / 4 GLU A 252
ASP A 167
ARG A 170
TRP A 441
 None
None
OAN  A2000 (-2.8A)
OAN  A2000 (-3.7A)
 1.04A 6mn8A-3sutA:
0.0		 6mn8A-3sutA:
22.69