SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3svt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 6 VAL A 143
GLY A 144
ALA A 230
LEU A 234
 None
 0.68A 1e7bB-3svtA:
undetectable		 1e7bB-3svtA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 8 ASP A  67
ILE A  68
THR A  69
LEU A 118
 None
 0.72A 1hmyA-3svtA:
7.0		 1hmyA-3svtA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 4 SER A 146
ILE A 145
VAL A 248
THR A 215
 None
 1.18A 1u70A-3svtA:
undetectable		 1u70A-3svtA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A  91
VAL A 183
GLU A 133
VAL A  37
THR A  13
 None
 1.02A 3dl9A-3svtA:
undetectable		 3dl9A-3svtA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 4 GLY A  46
VAL A  48
GLY A  14
THR A  13
 None
None
CL  A 279 (-3.7A)
None
 0.88A 3ib2A-3svtA:
undetectable		 3ib2A-3svtA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A  12
ALA A  45
GLY A  46
LEU A  51
ILE A  61
 None
 0.92A 3ku1A-3svtA:
6.8		 3ku1A-3svtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A  12
ALA A  45
GLY A  46
LEU A  51
ILE A  61
 None
 0.91A 3ku1C-3svtA:
6.9		 3ku1C-3svtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A  12
ALA A  45
GLY A  46
LEU A  51
ILE A  61
 None
 0.87A 3ku1G-3svtA:
6.6		 3ku1G-3svtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 GLY A  26
ALA A  25
GLY A  15
GLY A  20
ILE A  19
 None
None
CL  A 279 ( 4.6A)
None
None
 0.83A 3ufnA-3svtA:
undetectable		 3ufnA-3svtA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 GLY A  18
ILE A  68
THR A  69
GLY A  96
LEU A 118
 None
 1.16A 4n48A-3svtA:
7.7		 4n48A-3svtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 ILE A  68
THR A  74
ALA A 130
LEU A  11
PHE A 142
 None
 1.19A 4pbhA-3svtA:
undetectable		 4pbhA-3svtA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A 167
GLY A  96
ALA A  95
THR A  13
VAL A  91
 None
 0.91A 4xdrA-3svtA:
undetectable		 4xdrA-3svtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 7 GLY A 191
SER A 151
ARG A 194
ASP A 249
 None
 1.07A 5n5dB-3svtA:
8.4		 5n5dB-3svtA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		3 / 3 GLU A 133
HIS A 129
VAL A  78
 None
 0.89A 5trqB-3svtA:
undetectable		 5trqB-3svtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A  81
VAL A  78
MET A 171
GLY A 144
GLY A  38
 None
None
None
None
CL  A 279 ( 3.9A)
 1.08A 6brdC-3svtA:
3.9		 6brdC-3svtA:
17.69