SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 5 GLY A 204
LEU A 223
THR A 224
VAL A 220
None
None
None
GOL  A 507 (-3.9A)
0.87A 1ekjF-3sweA:
undetectable
1ekjG-3sweA:
undetectable
1ekjF-3sweA:
18.91
1ekjG-3sweA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
3 / 3 GLN A 148
ILE A  96
HIS A 127
None
None
EPZ  A 508 (-4.7A)
0.75A 1fm9A-3sweA:
undetectable
1fm9A-3sweA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 ALA A  24
LEU A 169
LEU A 200
ALA A 197
ILE A  28
None
1.19A 1g5yC-3sweA:
undetectable
1g5yC-3sweA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 ALA A 178
GLY A 130
ALA A 175
THR A 156
ILE A 171
None
1.23A 1gtnB-3sweA:
undetectable
1gtnC-3sweA:
undetectable
1gtnB-3sweA:
12.56
1gtnC-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 ALA A 178
GLY A 130
ALA A 175
THR A 156
ILE A 171
None
1.21A 1gtnH-3sweA:
undetectable
1gtnI-3sweA:
undetectable
1gtnH-3sweA:
12.56
1gtnI-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 GLY A 130
ALA A 175
THR A 156
ILE A 171
ALA A 178
None
1.19A 1gtnU-3sweA:
undetectable
1gtnV-3sweA:
undetectable
1gtnU-3sweA:
12.56
1gtnV-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
None
0.91A 1hrkA-3sweA:
undetectable
1hrkA-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 SER A 323
ASN A 316
GLN A 309
THR A 353
None
1.13A 1ig3A-3sweA:
undetectable
1ig3B-3sweA:
undetectable
1ig3A-3sweA:
20.88
1ig3B-3sweA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 ILE A 397
ILE A 404
GLU A 405
ARG A 417
None
0.89A 1mrjA-3sweA:
undetectable
1mrjA-3sweA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 LEU A 200
VAL A  62
LEU A  57
LEU A  74
LEU A 223
None
0.70A 1mx1D-3sweA:
undetectable
1mx1D-3sweA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 11 ALA A 243
ILE A 235
VAL A 251
LEU A 314
ALA A 310
None
1.12A 1rv7A-3sweA:
undetectable
1rv7B-3sweA:
undetectable
1rv7A-3sweA:
14.25
1rv7B-3sweA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.91A 1wmqA-3sweA:
undetectable
1wmqA-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.91A 1wmqB-3sweA:
undetectable
1wmqB-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.91A 1wpuA-3sweA:
undetectable
1wpuA-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.91A 1wpuB-3sweA:
undetectable
1wpuB-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.88A 1wrqA-3sweA:
undetectable
1wrqA-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ARG A 122
ILE A 119
GLY A 120
ALA A 121
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
QPA  A 117 ( 4.0A)
None
0.89A 1wrqB-3sweA:
undetectable
1wrqB-3sweA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
6 / 10 ALA A 244
ALA A 245
LEU A 315
LEU A 268
ALA A 271
VAL A 275
None
1.42A 2bxgB-3sweA:
undetectable
2bxgB-3sweA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
None
0.95A 2pnjA-3sweA:
undetectable
2pnjA-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 11 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
None
1.14A 2po5B-3sweA:
undetectable
2po5B-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 MET A 308
LEU A 261
LEU A 284
VAL A 275
VAL A  16
None
1.02A 2po7A-3sweA:
undetectable
2po7A-3sweA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 SER A 118
THR A 370
LEU A 372
ALA A 374
QPA  A 117 ( 2.9A)
None
EPZ  A 508 (-4.2A)
None
0.96A 3ax7A-3sweA:
undetectable
3ax7A-3sweA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 GLY A  20
ASP A 233
ILE A 235
GLY A 238
THR A 260
None
1.15A 3eeyJ-3sweA:
2.2
3eeyJ-3sweA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 9 ALA A 413
LEU A  12
VAL A 379
ILE A 246
LEU A 314
None
1.50A 3fl9D-3sweA:
undetectable
3fl9D-3sweA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 7 TYR A 401
LEU A 408
LEU A 380
SER A 375
None
1.04A 3lm8A-3sweA:
undetectable
3lm8C-3sweA:
undetectable
3lm8A-3sweA:
20.61
3lm8C-3sweA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 LEU A  74
ILE A  33
ALA A  31
THR A  53
None
1.07A 3mdrA-3sweA:
undetectable
3mdrA-3sweA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 5 TYR A  86
VAL A  89
SER A 112
GLY A 115
None
0.41A 3v4tA-3sweA:
66.9
3v4tD-3sweA:
67.2
3v4tA-3sweA:
74.23
3v4tD-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_D_ACTD503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 4 GLN A 110
GLU A 142
TYR A 144
LYS A 146
None
0.78A 3v4tD-3sweA:
67.2
3v4tD-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
3 / 3 LYS A  22
ARG A 122
LEU A 372
EPZ  A 508 (-2.5A)
EPZ  A 508 (-3.9A)
EPZ  A 508 (-4.2A)
0.63A 3v4tE-3sweA:
67.1
3v4tE-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
3 / 3 LYS A  22
ARG A 333
LEU A 372
EPZ  A 508 (-2.5A)
EPZ  A 508 (-3.7A)
EPZ  A 508 (-4.2A)
0.97A 3v4tE-3sweA:
67.1
3v4tE-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
6 / 7 ALA A  94
ILE A  96
TRP A  97
ARG A 122
HIS A 127
GLY A 166
EPZ  A 508 (-3.5A)
None
None
EPZ  A 508 (-3.9A)
EPZ  A 508 (-4.7A)
EPZ  A 508 (-3.5A)
0.33A 3v4tH-3sweA:
67.4
3v4tH-3sweA:
74.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 7 ARG A  93
ALA A  94
ILE A  96
ARG A 122
HIS A 127
QPA  A 117 ( 4.1A)
EPZ  A 508 (-3.5A)
None
EPZ  A 508 (-3.9A)
EPZ  A 508 (-4.7A)
0.66A 3v4tH-3sweA:
67.4
3v4tH-3sweA:
74.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
3 / 3 ARG A 399
ARG A 373
LYS A  22
QPA  A 117 (-3.1A)
None
EPZ  A 508 (-2.5A)
1.49A 3w1wA-3sweA:
undetectable
3w1wB-3sweA:
undetectable
3w1wA-3sweA:
21.57
3w1wB-3sweA:
21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 5 ARG A  93
ILE A  96
TRP A  97
GLY A 166
QPA  A 117 ( 4.1A)
None
None
EPZ  A 508 (-3.5A)
0.75A 4e7cC-3sweA:
60.5
4e7cC-3sweA:
74.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4E7C_C_ACTC506_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 5 ILE A  96
TRP A  97
HIS A 127
GLY A 166
None
None
EPZ  A 508 (-4.7A)
EPZ  A 508 (-3.5A)
0.29A 4e7cC-3sweA:
60.5
4e7cC-3sweA:
74.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 GLU A 190
ASP A 307
GLU A 327
ARG A 122
EPZ  A 508 ( 4.9A)
EPZ  A 508 (-2.7A)
None
EPZ  A 508 (-3.9A)
1.07A 4ntxA-3sweA:
undetectable
4ntxC-3sweA:
undetectable
4ntxA-3sweA:
22.20
4ntxC-3sweA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 GLY A 130
ALA A 175
THR A 156
ILE A 171
ALA A 178
None
1.22A 5eewO-3sweA:
undetectable
5eewP-3sweA:
undetectable
5eewO-3sweA:
12.56
5eewP-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 GLY A 130
ALA A 175
THR A 156
ILE A 171
ALA A 178
None
1.22A 5eexO-3sweA:
undetectable
5eexP-3sweA:
undetectable
5eexO-3sweA:
12.56
5eexP-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 GLY A 130
ALA A 175
THR A 156
ILE A 171
ALA A 178
None
1.22A 5ef2O-3sweA:
undetectable
5ef2P-3sweA:
undetectable
5ef2O-3sweA:
12.56
5ef2P-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 10 GLY A 130
ALA A 175
THR A 156
ILE A 171
ALA A 178
None
1.22A 5ef3O-3sweA:
undetectable
5ef3P-3sweA:
undetectable
5ef3O-3sweA:
12.56
5ef3P-3sweA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 HIS A 336
GLN A 309
LEU A 378
THR A 239
None
1.16A 5hs6A-3sweA:
undetectable
5hs6A-3sweA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 6 ALA A  94
PRO A 114
VAL A  89
ASP A  49
EPZ  A 508 (-3.5A)
None
None
None
0.98A 5umd2-3sweA:
undetectable
5umdF-3sweA:
undetectable
5umd2-3sweA:
13.38
5umdF-3sweA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 ARG A 290
SER A 363
THR A 386
GLY A 345
None
1.01A 5v0vA-3sweA:
undetectable
5v0vA-3sweA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 7 LEU A  41
ASP A 195
THR A 196
HIS A 127
None
None
None
EPZ  A 508 (-4.7A)
1.09A 5w97C-3sweA:
undetectable
5w97a-3sweA:
undetectable
5w97c-3sweA:
undetectable
5w97C-3sweA:
20.00
5w97a-3sweA:
21.04
5w97c-3sweA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 7 ILE A  96
LEU A  99
ILE A 160
ALA A 136
None
0.67A 6b5vA-3sweA:
undetectable
6b5vC-3sweA:
undetectable
6b5vA-3sweA:
11.86
6b5vC-3sweA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 7 ILE A  96
LEU A  99
ILE A 160
ALA A 136
None
0.68A 6b5vC-3sweA:
undetectable
6b5vD-3sweA:
undetectable
6b5vC-3sweA:
11.86
6b5vD-3sweA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 7 ALA A 136
ILE A  96
LEU A  99
ILE A 160
None
0.67A 6b5vB-3sweA:
undetectable
6b5vD-3sweA:
undetectable
6b5vB-3sweA:
11.86
6b5vD-3sweA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 TYR A 395
LEU A  47
GLY A 400
VAL A 391
ASP A 371
GOL  A 506 (-4.9A)
None
None
None
None
1.41A 6bxlB-3sweA:
undetectable
6bxlB-3sweA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 ARG A 122
ILE A 119
ASN A  23
ARG A 399
ASP A  49
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
EPZ  A 508 (-3.1A)
QPA  A 117 (-3.1A)
None
1.27A 6ekuA-3sweA:
undetectable
6ekuA-3sweA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_1
(SIALIDASE)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
5 / 12 ARG A 122
ILE A 119
ASP A 371
ASN A  23
ASP A  49
EPZ  A 508 (-3.9A)
QPA  A 117 ( 4.4A)
None
EPZ  A 508 (-3.1A)
None
1.37A 6ekuA-3sweA:
undetectable
6ekuA-3sweA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae)
4 / 8 LEU A  41
ASP A 195
THR A 196
HIS A 127
None
None
None
EPZ  A 508 (-4.7A)
1.06A 6nknC-3sweA:
undetectable
6nknN-3sweA:
undetectable
6nknP-3sweA:
undetectable
6nknC-3sweA:
20.00
6nknN-3sweA:
21.04
6nknP-3sweA:
20.00