SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3swg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 VAL A 162
ALA A 177
PHE A 138
GLU A 140
 None
 1.07A 1dmiA-3swgA:
undetectable
1dmiB-3swgA:
undetectable		 1dmiA-3swgA:
20.82
1dmiB-3swgA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 PHE A 316
ALA A 318
THR A 244
LEU A 347
LEU A 344
 None
 1.17A 1jipA-3swgA:
undetectable		 1jipA-3swgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 SER A  28
ASP A 238
GLU A 410
GLU A 409
 None
 1.17A 1knyA-3swgA:
undetectable
1knyB-3swgA:
undetectable		 1knyA-3swgA:
20.84
1knyB-3swgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 SER A  28
GLU A 406
GLU A 410
GLU A 409
 None
 1.13A 1knyA-3swgA:
undetectable
1knyB-3swgA:
undetectable		 1knyA-3swgA:
20.84
1knyB-3swgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 GLU A 410
GLU A 409
SER A  28
GLU A 406
 None
 1.05A 1knyA-3swgA:
undetectable
1knyB-3swgA:
undetectable		 1knyA-3swgA:
20.84
1knyB-3swgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 206
LEU A 104
LEU A 179
LEU A  35
PHE A 231
 None
 1.07A 1mx1C-3swgA:
undetectable		 1mx1C-3swgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.95A 1wmqA-3swgA:
undetectable		 1wmqA-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.95A 1wmqB-3swgA:
undetectable		 1wmqB-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.96A 1wpuA-3swgA:
undetectable		 1wpuA-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.96A 1wpuB-3swgA:
undetectable		 1wpuB-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.94A 1wrqA-3swgA:
undetectable		 1wrqA-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 129
ILE A 126
GLY A 127
ALA A 128
 EPZ  A 518 (-4.0A)
QPA  A 124 ( 4.0A)
QPA  A 124 ( 3.6A)
None
 0.95A 1wrqB-3swgA:
undetectable		 1wrqB-3swgA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 LEU A  66
LEU A  63
LEU A  57
MET A  38
 None
EDO  A 511 ( 4.4A)
None
None
 1.03A 2oaxF-3swgA:
undetectable		 2oaxF-3swgA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		3 / 3 SER A 321
HIS A 339
ASP A 397
 None
 0.67A 2oxtA-3swgA:
undetectable		 2oxtA-3swgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 366
LEU A 295
VAL A 247
GLY A 248
 None
 0.84A 2po5A-3swgA:
undetectable		 2po5A-3swgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 366
LEU A 295
VAL A 247
GLY A 248
 None
 0.91A 2po5B-3swgA:
undetectable		 2po5B-3swgA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 LEU A 287
LEU A 258
ILE A 263
ARG A 262
 None
 0.96A 2rlfC-3swgA:
undetectable
2rlfD-3swgA:
undetectable		 2rlfC-3swgA:
7.26
2rlfD-3swgA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 LEU A 206
ALA A 177
GLY A 107
PHE A 231
 None
 0.96A 2wq5A-3swgA:
undetectable		 2wq5A-3swgA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 SER A 125
THR A 374
LEU A 376
ALA A 378
 QPA  A 124 ( 3.3A)
None
EPZ  A 518 (-4.4A)
None
 0.96A 3ax7A-3swgA:
undetectable		 3ax7A-3swgA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 386
SER A 381
LEU A 401
ILE A 419
LEU A 344
 None
 1.20A 3g9eA-3swgA:
undetectable		 3g9eA-3swgA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 118
LEU A  43
PHE A  39
THR A  41
LEU A  66
 None
 1.21A 3j6pB-3swgA:
undetectable		 3j6pB-3swgA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 SER A 125
THR A 374
LEU A 376
ALA A 378
 QPA  A 124 ( 3.3A)
None
EPZ  A 518 (-4.4A)
None
 1.00A 3ns1L-3swgA:
undetectable		 3ns1L-3swgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 10 ILE A  90
ASN A 155
ALA A 116
LEU A  69
LEU A 109
 EDO  A 507 (-4.3A)
None
None
None
None
 1.20A 3o02A-3swgA:
undetectable
3o02B-3swgA:
undetectable		 3o02A-3swgA:
22.76
3o02B-3swgA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 PHE A  13
ASP A 402
ALA A 249
THR A 252
ALA A 417
 None
 1.29A 3ua1A-3swgA:
undetectable		 3ua1A-3swgA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		3 / 3 LYS A  31
ARG A 129
LEU A 376
 EPZ  A 518 (-2.6A)
EPZ  A 518 (-4.0A)
EPZ  A 518 (-4.4A)
 0.61A 3v4tE-3swgA:
61.1		 3v4tE-3swgA:
44.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		3 / 3 LYS A  31
ARG A 337
LEU A 376
 EPZ  A 518 (-2.6A)
EPZ  A 518 ( 4.1A)
EPZ  A 518 (-4.4A)
 1.06A 3v4tE-3swgA:
61.1		 3v4tE-3swgA:
44.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 ARG A 100
ALA A 101
ARG A 129
HIS A 134
 QPA  A 124 ( 4.0A)
EPZ  A 518 (-3.6A)
EPZ  A 518 (-4.0A)
EPZ  A 518 ( 4.9A)
 0.69A 3v4tH-3swgA:
61.2		 3v4tH-3swgA:
44.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 ARG A 129
VAL A 103
LEU A 104
SER A 102
 EPZ  A 518 (-4.0A)
None
None
None
 1.30A 4e1gA-3swgA:
undetectable		 4e1gA-3swgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 10 LEU A 202
PRO A 108
GLU A 175
PHE A 137
LEU A 181
 None
None
EPZ  A 518 ( 4.6A)
None
None
 1.42A 4la0A-3swgA:
undetectable		 4la0A-3swgA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 5 ARG A 239
ASP A 311
GLU A 241
VAL A 383
 None
EPZ  A 518 (-2.7A)
None
None
 1.37A 4nkvB-3swgA:
undetectable		 4nkvB-3swgA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 GLU A 196
ASP A 311
GLU A 331
ARG A 129
 None
EPZ  A 518 (-2.7A)
None
EPZ  A 518 (-4.0A)
 1.06A 4ntxA-3swgA:
undetectable
4ntxC-3swgA:
undetectable		 4ntxA-3swgA:
23.37
4ntxC-3swgA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 SER A 373
LEU A  56
LEU A 401
THR A 310
ALA A 380
 None
None
None
EPZ  A 518 (-4.4A)
None
 1.23A 4x1kA-3swgA:
undetectable
4x1kB-3swgA:
undetectable		 4x1kA-3swgA:
23.05
4x1kB-3swgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 LEU A 179
LEU A 195
ILE A 193
LEU A 190
VAL A 199
 None
 1.12A 4y0qA-3swgA:
undetectable		 4y0qA-3swgA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		3 / 3 LEU A 120
ARG A  97
ARG A 100
 None
None
QPA  A 124 ( 4.0A)
 0.72A 4yiaB-3swgA:
undetectable		 4yiaB-3swgA:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 LEU A 273
LEU A 384
GLY A 248
ALA A 249
 None
 0.83A 5f1aA-3swgA:
undetectable		 5f1aA-3swgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 7 ILE A 276
GLY A 277
LEU A 415
ASP A 253
 None
 0.77A 5hieB-3swgA:
undetectable		 5hieB-3swgA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 8 HIS A 340
GLN A 313
LEU A 382
THR A 244
 None
 1.03A 5hs6A-3swgA:
undetectable		 5hs6A-3swgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		3 / 3 VAL A 215
LEU A 228
MET A 209
 None
 0.86A 5ikrA-3swgA:
undetectable		 5ikrA-3swgA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 12 PHE A  13
ASP A 402
ALA A 249
THR A 252
ALA A 417
 None
 1.27A 5vcgA-3swgA:
undetectable		 5vcgA-3swgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		4 / 6 ARG A 365
LEU A 366
ALA A 318
GLN A 390
 None
 0.79A 6b89B-3swgA:
undetectable		 6b89B-3swgA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE
(Aquifex
aeolicus) 		5 / 9 LEU A 178
THR A 174
ILE A 193
VAL A 215
ILE A 203
 None
 1.10A 6ef6A-3swgA:
undetectable		 6ef6A-3swgA:
21.59